Niacin NR (for Longevity & Metabolic Repair)

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Niacin functions in over fifty metabolic reactions. It plays a key role in glycolysis, the Krebs Cycle and the hexose monophosphate shunt, all of which are important in the release of energy from macro-nutrients. It is also needed in the deamination of amino acids, essential fatty acid metabolism and in the metabolism of fatty acids. By playing a role in the formation of red blood cells, steroids, and in energy production within the cells, niacin is vital in maintaining the integrity of all body cells.

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Description

Niacin (NR)

Vitamin B3, a water soluble nutrient, appears in several different forms, all of which can be referred to as niacin.

One of the forms of Niacin is nicotinamide which is in NiacinB3, (synonymous with niacinamide) which is the form of niacin that is generally recommended for supplements, however new versions of Nictotinamide, Nicotinamide Riboside (NR) and the Nicotinamide MonoNucleotide (NMN) version is changing everything we thought we knew about metabolic decline aging and reversing dis-ease.

 

In 2013, research published by Dr David Sinclair demonstrated that short term supplementation with Nicotinamide MonoNucleotide (NMN) replenished NAD+ and reversed many aspects of aging, making the cells of old mice resemble those of much younger mice, and greatly improving their health (source), by the time we reach 50 years old our NAD+ levels are only 50% of the levels in our youth.

“Our data show that 1 week of treatment with a compound that boosts NAD+ levels is sufficient to restore the mitochondrial homeostasis and key biochemical markers of muscle health in a 22-month-old mouse to levels similar to a 6-month-old mouse.” ~ Prof. David Sinclair (Harvard)

This experiment is featured in the below chat show.

NAD+ is the key for Healthy Aging
As we age, our levels of the Co-enzyme Nicotinamide Adenine Dinucleotide NAD+ drop significantly in multiple organs in mice and humans (5, 8, 10). NAD+ is a key Co-enzyme used by our mitochondria for energy production in all our cells. Higher NAD+ levels are needed for our cells to function at their best. NAD+ decrease is described as a trigger in age-associated decline(23), and perhaps even the key factor in why we age (5).

Read:  The New Molecule Revolutionising Anti-Ageing Movement

The chemical structure of niacin is similar to the amino acid tryptophan and in fact the body can make niacin from tryptophan but in times of stress this function can become compromised. Niacin is most abundant in high protein foods such as meat, fish and nuts though the amounts are quite low.

Nicotinamide Riboside NAM NMN NR Diagram Sirtuin

 

NAD+ is essential for life in all organisms, both as a coenzyme for oxidoreductases and as a source of ADPribosyl groups used in various reactions, including those that retard aging in experimental systems. Nicotinic acid and nicotinamide were defined as the vitamin precursors of NAD+ in Elvehjem’s classic discoveries of the 1930s. The accepted view of eukaryotic NAD+ biosynthesis, that all anabolism flows through nicotinic acid mononucleotide, was challenged experimentally and revealed that nicotinamide riboside is an unanticipated NAD+ precursor in yeast.

Possible Nicotinamide Benefits:

Detox: Combination of niacin (Nicotinamide NR) , exercise and sauna is a powerful way to detox your body from heavy metals and toxins stored in fat cells.

Energy: Niacin (Nicotinamide NR)  is essential in the production of energy in the body. Deficiency causes tiredness and fatigue. Daily will give a natural energy boost.

Arthritis: Studies confirm niacin is better than NSAIDS for arthritis. Moderate arthritis.

Cholesterol, Triglycerides + Reversing Heart Disease: Niacin (Nicotinamide NR)  lowers cholesterol more effectively than statins in various studies and also lowers triglycerides. It reduces the blood fats called “very low density lipoproteins,” which have been linked to heart disease and cancer. It improves the blood sugar problems that can lead to damage of the arterial walls. It dilates blood vessels, which improves the circulation to areas starved of oxygen and nutrients.

Memory loss: Taken 3 times a day can improve memory, and correct some senility problems.

Prevents Hair Loss + Balding: Increases blood flow to scalp, important in hair growth and reduces production of DHT linked to balding.

Insomnia: (Nicotinamide NR) activates benzodiazepine receptors in the brain, which affects sleep. Niacin NR that is converted into niacinamide in the body taken at bedtime have helped many people sleep better.

Severe Depression & Schizophrenia: The usual dose range is 3,000 to 9,000 milligrams of Niacin (Nicotinamide NR)  daily divided into three doses, however, NiacinNR is more bioavailable and 125mg dosages 3 – 4 daily may suffice.

Cancer: Has the potential to influence DNA repair, genomic stability, and the immune system, eventually having an impact on cancer risk, as well as the side effects of chemotherapy in the cancer patient. Low levels of NAD+ synthesis can cause DNA damage. Niacin supplementation increases NAD+ levels, which can help protect against DNA damage, oxidative damage, and tumor progression

Acne: Many reports show Niacin can get rid of acne.

Alzheimers: Studies have shown that vitamin B3 niacin (Nicotinamide NR) can help protect against Alzheimer’s disease and other age related brain disorders that result in cognitive decline.

Niacin functions in over fifty metabolic reactions. It plays a key role in glycolysis, the Krebs Cycle and the hexose monophosphate shunt, all of which are important in the release of energy from macro-nutrients. It is also needed in the deamination of amino acids, essential fatty acid metabolism and in the metabolism of fatty acids. By playing a role in the formation of red blood cells, steroids, and in energy production within the cells, niacin is vital in maintaining the integrity of all body cells.

Niacin Deficiency in Cancer

Niacin is an important B3 vitamin naturally produced and synthesized in the liver by tryptophan to produce NAD coenzymes. NAD coenzymes keep the Krebs’ Citric Acid Cycle in the mitochondria of cells functioning normally. It is also implicated in Cancer as a Niacin Deficiency, if there is insufficient NAD coenzymes due to a depletion of tryptophan and niacin [caused by prolonged psycho-emotional stress] then the Krebs’s Citric Acid Cycle of the cell is broken and the cell reverts to glucose obtain smaller amounts of ATP energy for the cell and for the body.

When the cell ferments glucose to obtain ATP energy it produces lactic acid, and the somatid (tiny microorganisms necessary for life that live in our blood) pleomorphise (or change) into pathogenic viral-bacterial-yeast-like-fungus to ferment rising glucose and lactic acid, subsequently migrating to the cell nucleus and causing cell mutation and cancer.

Fermentation as an alternate means to obtain smaller amounts of ATP energy for the cell and for the body. When the cell ferments glucose to obtain ATP energy it produces lactic acid, and the somatid (tiny microorganisms necessary for life that live in our blood) pleomorphise (or change) into pathogenic viral-bacterial-yeast-like-fungus to ferment rising glucose and lactic acid, subsequently migrating to the cell nucleus and causing cell mutation and cancer.

In 1949, the American biochemists Morris Friedkin and Albert L. Lehninger proved that NADH linked metabolic pathways such as the citric acid cycle with the synthesis of ATP in oxidative phosphorylation. [source]

Suggested Usage:

Start slowly with one capsule with or without food and gradually build up to desired level. Best combined with Resveratrol see Trans-Resveratrol , AlgaeDHA and Electrolytes Drink Electrobal+.

 

Quality Assurance Declaration

Lab-Tested
Werone.co endeavors to use the most potent source materials within our formulas. Our herbal extracts are sourced and tested by the only Government-certified large scale producer of crude herb (powder-free) TCM concentrates in Asia who manufacture to GMP / ISO 9001/2000 pharmaceutical grade and also operate an ISO17025/TAF-certified laboratory where they subject all plant extracts to strict quality inspections free from heavy metals, pesticides or microbes before release to the clinics all over the world. The formulas and tinctures are assembled without fillers in small batches by a BHMA member herbal dispensary.

 

Nutraceutical Disclaimer

These statements have not been evaluated by the Food and Drug Administration or MHRA and the items are not intended to diagnose, treat, cure, or prevent any disease nor are they associated, endorsed, affiliated or sponsored by Anthony William, Medical Medium® Joe Tippens or Jim Gordon.

 

Testimonials

A godsend for those with Chronic Fatigue and Autoimmune disorders
By Basanga
A little background: I’ve had UC almost all my life, and at age 24 it took a turn for the worse and spread to other parts of my body due to a case of encephalitis brought on by toxoplasmosis. After the encephalitis, my life became an absolute mess, and I tried every anti-inflammatory under the sun. They helped for a while, but they kept weakening my immune system and letting the toxoplasmosis get worse. Anti-microbals kept it in check, but weren’t a long-term solution, and kept doing numbers on my liver. So after reading all sorts of research on NR, I sucked it up and finally bought it.

I was extremely sceptical of its effects, as I have been burnt before by many other supplements that make claims of reducing inflammation but not impacting your immune system negatively. I started with 2 capsules, on an empty stomach straight after I wake up. The first day, my energy was definitely improved, but the inflammation remained and affected my mood still. By the second day, my energy improved further, and the inflammation weakened. By the third day, it’s as if the inflammation isn’t even there, my energy is amazing and my mood was at an all-time high. The things that I would avoid and neglect out of fatigue excited me once again! Honestly, this is one supplement I can’t be without. The price is very steep, but the results are indescribable, it’s done a complete 180 on my life. If you can afford it, try it for at least a month. Most healthy people won’t see my kind of results, but for those with autoimmune disorders and chronic fatigue, it may very well give you your life back.

works!
By Member
Worked both for me and a friend more energy…

Highly Recommemded
By Member
NiacinNR is a great product, it provides greater levels of energy and clears your mind in thought processes. Turns back the years.

NR from same factory as more expensive brands
By Anon
This Nicotinamide Riboside is actualy made in the same factory, with exactly the same methods, as much more expensive brands like Niagen. I can prove myself that the effects are exactly the same and are amazing! This is the future of the supplements, first truly groundbreaking invention in this field in many, many years. Highly recommended!

Really works
By Member
weight loss, more energy, skin looks better. saw this vitamin in womans world

Wow! What an Energy Boost!
By Member
My doctor has been suggesting different supplements for a year now, in an effort to help boost my energy level. Niacel is his most recent suggestion. Boom! Success! This is a really fine product. I take only one per day and noticed a real boost in my energy levels from the first capsule. I’ve had no side effects from this supplement and found it a good size, easy to swallow and very effective. I’m very glad to add this to my daily health protocols and will most certainly purchase it again.

Seems to have positive benefits
In the last few weeks I’ve increased my dose from one to two capsules a day and I must say I am feeling brighter, and happier with fewer mood swings. I feel more balanced and positive in my outlook and have more physical energy. Is this effect related to the product? Can’t tell, really but I shall continue to take it as on the basis of my reading about it, it does seem beneficial.

References:

  1. Detection and pharmacological modulation of nicotinamide mononucleotide (NMN) in vitro and in vivo(Formentini, 2009)
  2. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity (Cato, 2009)
  3. A possibility of nutriceuticals as an anti-aging intervention: activation of sirtuins by promoting mammalian NAD biosynthesis (Imai, 2010)
  4. NAD blocks high glucose induced mesangial hypertrophy via activation of the sirtuins-AMPK-mTOR pathway(Zhuo, 2011)
  5. Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice (Yoshino, 2011)
  6. The NAD (+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity(Canto, 2012 )
  7. NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice. (Zhang, 2016)
  8. Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging (Gomes, Sinclair,2013)
  9. Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, protects the heart from ischemia and repercussion (Yamamoto, 2014)
  10. NAD+ and sirtuins in aging and disease (Imai, 2014)
  11. Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3 (Khan, 2014)
  12. Effect of nicotinamide mononucleotide on brain mitochondrial respiratory deficits in an Alzheimer’s disease-relevant murine model (Long, 2015)
  13. NAD+ metabolism and the control of energy homeostasis – a balancing act between mitochondria and the nucleus (Canto, 2015)
  14. NAD+ metabolism: Bioenergetics, signaling and manipulation for therapy (Yang, 2016)
  15. NAD+ replenishment improves lifespan and healthspan in ataxia telangiectasia models via mitophagy and DNA repair( Fang, 2016 )
  16. Nicotinamide riboside is uniquely and orally bioavailable in mice and humans(Trammell, 2016a )
  17. Nicotinamide riboside opposes type 2 diabetes and neuropathy in mice(Trammell, 2016b )
  18. β-Nicotinamide Mononucleotide, an Anti-Aging Candidate Compound, Is Retained in the Body for Longer than Nicotinamide in Rats (Kawamura, 2016)
  19. The first human clinical study for NMN has started in Japan (Tsubota, 2016)
  20. Nicotinamide mononucleotide protects against β-amyloid oligomer-induced cognitive impairment and neuronal death (Wang, 2016)
  21. Head to Head Comparison of Short-Term Treatment with the NAD(+) Precursor Nicotinamide Mononucleotide (NMN) and 6 Weeks of Exercise in Obese Female Mice (Uddin, 2016)
  22. Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice (Mills, 2016)
  23. Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice (de Picciotto, 2016)
  24. Nicotinamide mononucleotide inhibits JNK activation to reverse Alzheimer disease (Yao, 2017)
  25. Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich’s ataxia cardiomyopathy model (Martin, 2017)
  26. Nicotinamide Mononucleotide, an NAD+ Precursor, Rescues Age-Associated Susceptibility to AKI in a Sirtuin 1-Dependent Manner (Guan, 2017)
  27. Nicotinamide mononucleotide attenuates brain injury after intracerebral hemorrhage by activating Nrf2/HO-1 signaling pathway (Wei, 2017)
  28. Short-term administration of Nicotinamide Mononucleotide preserves cardiac mitochondrial homeostasis and prevents heart failure (Zhang, 2017)
  29. Modulating NAD+ metabolism, from bench to bedside (Auwerx, 2017)
  30. Aspects of Tryptophan and Nicotinamide Adenine Dinucleotide in Immunity: A New Twist in an Old Tale. (Rodriguez, 2017)
  31. Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice (Williams, 2017)
  32. NAMPT-mediated NAD biosynthesis as the internal timing mechanism: In NAD+ World, time is running in its own way (Poljsak, 2017)
  33. Effect of “Nicotinamide Mononucleotide” (NMN) on Cardiometabolic Function (NMN)
  34. The dynamic regulation of NAD metabolism in mitochondria (Stein, 2012)
  35. Novel NAD+ metabolomic technologies and their applications to Nicotinamide Riboside interventions(Trammel, 2016)
  36. Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: a randomized controlled trial in non-obese humans (Meydayni, 2016)
  37. A high-fat, ketogenic diet induces a unique metabolic state in mice. (Kennedy, 2007)
  38. Ketone body metabolism and cardiovascular disease.(Cotter, 2013)
  39. Ketone bodies as signaling metabolites(Newman, 2014)
  40. The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease(Youm, 2015)
  41. The effect of the Spanish Ketogenic Mediterranean Diet on nonalcoholic fatty liver disease: a pilot study.(Guisado, 2011)
  42. β-Hydroxybutyrate: A Signaling Metabolite in starvation response(Morales, 2016)
  43. Physiological roles of ketone bodies as substrates and signals in mammalian tissues(Robinson, 1980)
  44. Ketone bodies mimic the life span extending properties of caloric restriction (Veech, 2017)
  45. Novel ketone diet enhances physical and cognitive performance(Murray, 2016)
  46. Mitochondrial biogenesis and increased uncoupling protein 1 in brown adipose tissue of mice fed a ketone ester diet.
  47. Nutritional Ketosis Alters Fuel Preference and Thereby Endurance Performance in Athletes(Cox, 2013)
  48. Neuroendocrine Factors in the Regulation of Inflammation: Excessive Adiposity and Calorie Restriction (Fontana, 2009)
  49. Beta-adrenergic receptors are critical for weight loss but not for other metabolic adaptations to the consumption of a ketogenic diet in male mice(August, 2017)
  50. A randomized trial of a low-carbohydrate diet for obesity(Foster, 2003)
  51. β-Hydroxybutyrate suppresses inflammasome formation by ameliorating endoplasmic reticulum stress via AMPK activation(Bae, 2016)
  52. The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies. (Maalouf, 2009)
  53. AMPK activation protects cells from oxidative stress‐induced senescence via autophagic flux restoration and intracellular NAD + elevation (Han, 2016)
  54. Regulation of AMP-activated protein kinase by natural and synthetic activators (Hardie, 2015)
  55. Effects of Exhaustive Aerobic Exercise on Tryptophan-Kynurenine Metabolism in Trained Athletes (Strasser, 2016)
  56. PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation(Bai, 2011)
  57. Carbohydrate restriction regulates the adaptive response to fasting (Klein, 1992)
  58. Interventions to Slow Aging in Humans: Are We Ready? (longo, 2015)
  59. Extending healthy life span–from yeast to humans (longo, 2010)
  60. Dietary restriction with and without caloric restriction for healthy aging (Lee, 2016)
  61. A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan (Longo, 2015)
  62. Diet mimicking fasting promotes regeneration and reduces autoimmunity and multiple sclerosis symptoms(Longo, 2016
  63. Resistance Exercise Training Alters Mitochondrial Function in Human Skeletal Muscle (Porter, 2015)
  64. Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice (Newman, 2017)
  65. The NAD(+)/sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling.  (Mouchiroud, 2013)
  66. NAMPT- mediated NAD(+) biosynthesis is essential for vision in mice  (Lin, 2016)
  67. NAD+ replenishment improves lifespan and healthspan in ataxia telangiectasia models via mitophagy and DNA repair( Fang, 2016 )
  68. Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease (Gariani, 2017 )
  69. Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle(Canto, 2010)
  70. The NAD (+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity(Canto, 2012 )
  71. Nicotinamide riboside is uniquely and orally bioavailable in mice and humans(Trammell, 2016a )
  72. Nicotinamide riboside opposes type 2 diabetes and neuropathy in mice(Trammell, 2016b )
  73. Dietary leucine stimulates SIRT1 signaling through activation of AMPK (Hongliang, 2012)
  74. Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3 (Khan, 2014)
  75. NAD blocks high glucose induced mesangial hypertrophy via activation of the sirtuins-AMPK-mTOR pathway(Zhuo, 2011)
  76. The effect of different exercise regimens on mitochondrial biogenesis and performance (Philander, 2014)
  77. Dietary proanthocyanidins boost hepatic NAD+ metabolism and SIRT1 expression and activity in a dose-dependent manner in healthy rats (Aragon’s, 2016)
  78. NAD+ Deficits in Age-Related Diseases and Cancer (Garrido, 2017)
  79. Anti-diabetic and anti-lipidemic effects of chlorogenic acid are mediated by ampk activation (Ong, 2013)
  80. Chlorogenic Acid Improves Late Diabetes through Adiponectin Receptor Signaling Pathways in db/db Mice(Chang, 2015)
  81. Adenosine Monophosphate (AMP)-Activated Protein Kinase: A New Target for Nutraceutical Compounds(Marin-Aguilar, 2017)
  82. The Effects of Ramadan Fasting on Body Composition, Blood Pressure, Glucose Metabolism, and Markers of Inflammation in NAFLD Patients: An Observational Trial (Mazidi, 2014)
  83. Comparative effects of carbohydrate versus fat restriction on metabolic profiles, biomarkers of inflammation and oxidative stress in overweight patients with Type 2 diabetic and coronary heart disease: A randomized clinical trial. (Raygan, 2016)
  84. Normal fasting plasma glucose and risk of type 2 diabetes diagnosis (Nichols, 2008)
  85. Are We All Pre-Diabetic? (Stokel,2016)
  86. Hepatic NAD+ deficiency as a therapeutic target for non-alcoholic fatty liver disease in aging (Zhou, 2016)
  87. Effect of exercise intensity on post-exercise oxygen consumption and heart rate recovery (Mann,2014)
  88. A 45-minute vigorous exercise bout increases metabolic rate for 14 hours (Knab,2011)
  89. Effects of high-intensity resistance training on untrained older men. II. Muscle fiber characteristics and nuclei-cytoplasmic relationships (Gerontol, 2000)
  90. Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice (Newman, 2017)
  91. A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice (Roberts, 2017)
  92. NK cells link obesity-induced adipose stress to inflammation (Wensveen, 2015)
  93. The “Big Bang” in obese fat: Events initiating obesity-induced adipose tissue inflammation (Wensveen, 2015)
  94. The impact of the Standard American Diet in rats: Effects on behavior, physiology and recovery from inflammatory injury(Totsch, 2017)
  95. Bioenergetic state regulates innate inflammatory responses through the transcriptional co-repressor CtBP(Shen, 2017)
  96. The Ketogenic Diet as a Treatment Paradigm for Diverse Neurological Disorders (Stafstrom, 2012)
  97. Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle (Fredrick 2016)
  98. Digestion and absorption of NAD by the small intestine of the rat (Henderson, 1983)
  99. Effects of a wide range of dietary nicotinamide riboside (NR) concentrations on metabolic flexibility and white adipose tissue (WAT) of mice fed a mildly obesogenic diet(Shi, 2017)
  100. Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans (Brenner, 2004)
  101. Nampt Expression Decreases Age-Related Senescence in Rat Bone Marrow Mesenchymal Stem Cells by Targeting Sirt1 (Ma, 2017)
  102. NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR (Yoshino, 2017)

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