Methylsulfonylmethane (MSM) is an organic, sulfur-containing natural compound without any toxicity that has now been shown in a recent study to inhibit breast cancer growth. This includes suppressing triple-negative breast cancer. Scientists demonstrated that MSM substantially decreased the viability of human breast cancer cells in a dose-dependent manner. The higher the dose, the higher the benefits. The study showed reduced expression of breast cancer in just 30 days.
The role of sulfur in the body
Sulfur makes up one quarter of the total body weight and is the third most abundant mineral in the human body. Half of the sulfur in the body is in muscles, skin and bones. Sulfur is critical for making joint cartilage and keratin of the skin and hair, and new research suggests that sulfur is almost as significant as Vitamin C because the human body must maintain a minimum level of sulfur for normal function.
The body uses up to an eighth of a teaspoon of sulfur daily to keep the cell membranes open and prevent the hardening of tissues. New cells in our bodies need an exorbitant supply of sulfur and sulfur is even in the hemoglobin of the blood. Sulfur is not stored in the body and any surplus is oxidized to sulfate and excreted in the urine or is stored as glutathione.
Sulfur deficiency is linked to a host of degenerative diseases, such as: pain, joint trouble, fatigue, increased psychological and physical stress, and depression, as well as other conditions. Some children with autism have a low level of sulfate in their bodies due to poor absorption in the gut, excess loss in the urine, or poor recycling of sulfate by the kidney. Oxidative stress and inflammation can shut down cysteine dioxygenase, to block the cysteine -> sulfate route.
MSM – Meet the miracle!
MSM in supplement form mimics the organic sulfur present in our bodies. MSM is also known as dimethyl sulfone which is the sulfur compound nutrient found throughout the diets of virtually all vertebrates. It is odorless in its purified chemical form and is a water-soluble, white crystalline solid. It belongs in the same chemical family as oxygen and is a powerful antioxidant and detoxifier that even binds and assists in the removal of heavy metals from the body.
When your body is injured, MSM promotes healthy circulation to the injured area so nutrients can rush in for repairs. MSM has an antiseptic and cleansing effect on the digestive tract while stimulating bile secretions, purifying the blood, improving hair condition, helping liver function while boosting metabolism, and is used to produce glutathione – all while working overtime to prevent the accumulation of toxic impurities.
MSM is also one really great supplement for repairing joint troubles and carpal tunnel syndrome.
Dietary sources of sulfur
Sulfur is found in raw milk (but not pasteurized milk), meat, fish, fruits, vegetables and grains. One of the best sources for sulfur is garlic and onions. Unfortunately, our processed food diets do not deliver adequate amounts of this nutrient. Processing, drying, cooking and preserving strips our foods of sulfur, making supplementation more important than ever. Supplemental MSM is a safe and natural way to reap the therapeutic benefits of sulfur.
Expression of Stats and Triple-negative Receptors are down-regulated by MSM
The expression of STAT proteins and triple-negative hormone receptors was down-regulated in response to MSM in a dose-dependent manner in non-aggressive tumor cells like SK-BR3, MCF-7, and T-47D (Fig. 2A). In MDA-MB 231 cells expression of STAT proteins decreased. The expression of IGF-1R decreased in the entire breast cancer cell lines treated with 300 mM of MSM whereas it found unaltered in normal cell line MCF-10A. This was also observed for STAT5b and STAT3. The STAT5 phosphorylation level also found unaltered by MSM in normal MCF-10A cells. The expression of triple-negative hormone receptors, Her-2, ER-a, and PR as well found to be suppressed by 300 mM of MSM
MSM is a dietary supplement that does not require a prescription. A daily dose of 1,000 mg is common, and for some conditions, doses as high as two to six grams may be appropriate when taken for bowel tolerance (if the stool becomes loose, back off the dosage). Just add to food or drinks 3 times a day.
Try some for a while and see if things improve in your health.
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Werone.co endeavors to use the most potent source materials within our formulas. Our herbal extracts are sourced and tested by the only Government-certified large scale producer of crude herb (powder-free) TCM concentrates in Asia who manufacture to GMP / ISO 9001/2000 pharmaceutical grade and also operate an ISO17025/TAF-certified laboratory where they subject all plant extracts to strict quality inspections free from heavy metals, pesticides or microbes before release to the clinics all over the world. The formulas and tinctures are assembled without fillers in small batches by a BHMA member herbal dispensary.
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Methylsulfonylmethane suppresses breast cancer growth by down-regulating STAT3 and STAT5b pathways.
Methylsulfonylmethane inhibits HER2 expression through STAT5b in breast cancer cells.
MSM enhances GH signaling via the Jak2/STAT5b pathway in osteoblast-like cells and osteoblast differentiation through the activation of STAT5b in MSCs.