MelMagic™ is an exciting synergistic formula combining calming effects of Lemon Balm, Ashwagandha, Magnesium, Vit B6, Melatonin and Asia’s most well used anti-insomnia herb Jujuba Date Seed & (Ziziphus). It now comes in 10mg & 20mg Vegan 500mg capsule versions.
See here for MelMagic HD (100mg)
Melatonin is a natural neurohormone produced in humans by the pineal gland. A favourite of travellers, it governs the body’s circadian rhythms, helping the body ease into restful sleep and is also a potent antioxidant.
MelMagic™ Contains No Fillers!
Many supplements these days contain fillers which don’t actually help of support the active ingredient much, with MelMagic™ we decided to make a positive change by including complimentary and supportive ingredients to help the process of calming the busy mind, preparing the body for a rejuvenating and anti-oxidative sleep. To find out more about the amazing benefits of Melatonin, please watch the below short documentary.
Note: 5HTP is no longer within MelMagic™.
Melatonin & Cellular Health
Ingredients Within MelMagic™
Lemon balm (Melissa officinalis) is a well known herb, a member of the mint family that’s used both as a cooking ingredient and as a herbal medicine. It’s also well known for its ability to promote better sleep. It has been documented as far back as the Dark Ages as a means of relieving anxiety, promoting sleep, a painkiller as well as a cure for indigestion. These days, lemon balm is often mixed with other ingredients, like chamomile or hops, to create a relaxing formula which can help people sleep.
The key ingredient behind lemon balm’s sleeping aid properties is eugenol, a natural oily substance that can also be found in other plants, including basil, cinnamon and clove oil. Aside from being an anti-bacterial agent, eugenol also acts as a numbing agent, and is commonly used by dentists to relieve pain.
Zizyphus Seed (Jujube Date) is probably best known in the system of ancient Chinese medicine for its key role in the formula Suanzaoren Tang (Zizyphus Combination) of the Jingui Yaolue (220 A.D.). In that text, the formula is described simply as follows (3): “Zizyphus Combination treats weakness fatigue, and distress due to weakness, which causes insomnia.” Zizyphus is the main ingredient of the formula both in terms of the quantity used and its central action for the treatment of deficiency and insomnia, which are the formula’s main indications. Even today, if one discusses sedative formulas with prominent physicians in China, this formula is mentioned as being particularly effective; in books about using traditional formulas, Zizyphus Combination is among the first to be listed.
Melatonin May Be A Breast Tumor’s Worst Nightmare
The hormone melatonin produces a number of health benefits in terms of your immune system. It’s a powerful antioxidant and free radical scavenger that helps combat inflammation. In fact, melatonin is so integral to your immune system that a lack of it causes your thymus gland, a key component of your immune system, to atrophy. Melatonin may even have a role in slowing the aging of your brain.
In addition to helping you fall asleep and bestowing a feeling of overall comfort and well being, melatonin has proven to have an impressive array of anti-tumor benefits. Melatonin inhibits the proliferation of a wide range of tumor cell types, as well as triggering tumor cell apoptosis (self destruction). The hormone also interferes with the new blood supply tumors require for their rapid growth (angiogenesis). Melatonin can boost efficacy and decrease the toxicity of tumor chemotherapy.
Blue Light at Night May be Killing Us
Peer-reviewed and published research has shown melatonin offers particularly strong protection against reproductive tumors. Cells throughout your body — even tumor cells — have melatonin receptors. So when melatonin makes its nightly rounds, cell division slows. When this hormone latches onto a breast tumor cell, it has been found to counteract estrogen’s tendency to stimulate cell growth.
In fact, melatonin has a calming effect on several reproductive hormones, which may explain why it seems to protect against sex hormone-driven tumors, including ovarian, endometrial, breast, prostate and testicular tumor . GreenMedInfo lists twenty studies demonstrating exactly how melatonin exerts its protective effects against breast tumor .
But melatonin’s anti-tumor effects don’t stop there. While causing tumor cells to self-destruct, melatonin also boosts your production of immune stimulating substances such as interleukin-2, which helps identify and attack the mutated cells that lead to tumor . Through these dual actions, melatonin delivers a one-two punch!
Melatonin in the nanomolar range activates the intrinsic and/or the extrinsic apoptotic pathway in tumor cells, Melatonin is a CDK2 and CDK4 (cyclin-dependent kinases) inhibitor and for breast, gastro-intestinal, liver, ovarian, prostate, bone-tumor , melanoma & kidney tumors through an increase in the p53/MDM2p ratio and downregulation of Sirt1. This finding is of great relevance since there is intense research ongoing to identify nontoxic feasible inhibitors of MDM2 and Sirt1.
Melatonin is derived almost entirely from the pineal gland, as shown by the fact that undetectable melatonin levels are found . After its release, melatonin is bound to albumin and reaches tissues within a very short period . The melatonin molecule possesses lipophilic and hydrophilic properties that permit its transfer into many tissues and fluids. Depending upon the site of production and target organ, melatonin can act as a hormone, immuno-modulator or as a biological modifier .
Melatonin has been identified as a natural chronobiotic substance with immune-enhancing properties as well as the ability to reduce oxidative stress. Thus, melatonin could potentially be used as a therapeutic substance for the prevention or arrest of neoplastic growth . The concentrations of melatonin in ovarian follicles tend to increase with follicular growth . It is possible that melatonin acts as an antioxidant . Furthermore, the anti-apoptotic effect of melatonin has been observed in a variety of cell types . And there are indications that melatonin can help prevent and treat oxidative damage as well as suppress specific inflammatory factors .
Tumor Therapy Adjuvant and Immune Regulator
Emerging research suggests that melatonin has anti-carcinogenic properties—that is, it has the ability to prevent tumors from occurring, or to induce the tumor cell death if it does occur. This has been attributed to melatonin’s antioxidant, anti-inflammatory, anti-proliferative, and hormone-modulating properties.
It has been successfully used in individuals with advanced stage tumorsundergoing conventional antitumor therapy, by either slowing disease progression and/or decreasing treatment side effects. 53-60 In a review of 8 randomized, controlled clinical trials evaluating the benefits of melatonin as an adjuvant therapy for tumor patients with solid tumors undergoing chemotherapy or radiation therapy, researchers found that concurrent use of 20 mg of melatonin once daily versus conventional treatment alone, improved the rate of complete or partial remission by nearly 50%, increased the one-year survival rate by 45%, and decreased the devastating side effects of conventional therapy such as low platelet count, neuropathy, and fatigue by 89%, 83%, and 65% respectively. 59 What’s more, these effects were consistent across different types of tumor and there were no adverse events reported.
Melatonin’s anticarcinogenic properties can also be attributed to its effect on your immune system. Laboratory studies revealed that melatonin can activate T-helper cells, which triggers other immune cells in order to help kill off foreign invaders or pathogens. 61,62 Additionally, melatonin stimulates natural killer cell, monocyte, and macrophage synthesis, and has been found to facilitate healthy cell-to-cell communication, which enhances the body’s appropriate immune system response to foreign invaders. 63,64
Based on available evidence, leading experts suggest that patients with tumors and particularly metastatic solid tumors, might benefit from melatonin use, potentially leading to improved therapeutic outcomes. 62-70 Certainly, more research is warranted.
Melatonin not only inhibits breast tumor cell growth, but also is capable of inhibiting angiogenesis, tumor cell invasion and telomerase activity. Interestingly this hormone is able to induce apoptosis through the suppression or induction of a wide range of signaling pathways. Moreover, it seems that the concomitant administration of melatonin with other conventional chemotherapy agents had beneficial effects for patients with breast tumor , by alleviating unfavorable effects of those agents and enhancing their efficacy.
The broad inhibitory effects of melatonin in breast tumors make it a promising agent and may add it to the list of potential drugs in treatment of this tumor . https://www.ncbi.nlm.nih.gov/pubmed/27017208
Due to the sedative nature of melatonin, start with 1/2 or 1 capsule emptied into water or less and assess your personal response and gradually build up over a few days. If you feel groggy the next morning, the dose you have taken was too high; if you do not experience a deep restful sleep, your dose may have been too low. Do not exceed the suggested use unless recommended by your physician. If using for tumors, the target to build up to is 20mg to 40mg according to the studies, but do not try this initially, you’ll need to build up to it unless you are already accustomed to high levels. Combine with 10,000 IU Vitamin D3/K2 and cut out all veg oils and nuts from diet.
USE ONLY AT BEDTIME.
For adult use only. Not for use by children, teenagers, or women who are pregnant, may become pregnant or breastfeeding. Do not drive, operate machinery or consume alcohol or other sedatives while taking this supplement. If you are under medical supervision, or have an autoimmune disease, diabetes, a depressive disorder, a thyroid condition, epilepsy, leukemia, or a lymphoproliferative disorder, or are taking MAO inhibitor drugs or corticosteroids such as hydrocortisone or prednisone, consult your physician before taking this supplement.
Contraindications (Do not take melatonin in the following circumstances):
- * With Autoimmune conditions such as arthritis and lupus
- * If Taking an immunosuppressant
- * If Pregnant
- * Caution if you are taking a sedative, hypnotic (sleeping medications), blood pressure medications, seizure medications, diabetes medications
Despite melatonin’s antioxidant properties, it has demonstrated a tendency to stimulate inflammation in people with certain autoimmune disorders. A study published in the October 2007 issue of the “British Journal of Clinical Pharmacology” demonstrated that rheumatoid arthritis slightly worsened in study subjects who took melatonin [source] . Other autoimmune conditions which seem to benefit (slightly) are Crohns, IBD and Diabetes (see diagram below).
However, most autoimmune conditions are a result of leaky gut caused by grains, stress, heavy metals, bacteria and other toxins. Detoxing these and healing the gut is a more effective strategy. See our Heal Ur Gut™ range.
contains no yeast, dairy, egg, gluten, corn, soy or wheat. Contains no sugar, starch, salt, preservatives, or artificial color, flavor or fragrance.
Quality Assurance Declaration
Werone.co endeavors to use the most potent source materials within our formulas. Our herbal extracts are sourced and tested by the only Government-certified large scale producer of crude herb (powder-free) TCM concentrates in Asia who manufacture to GMP / ISO 9001/2000 pharmaceutical grade and also operate an ISO17025/TAF-certified laboratory where they subject all plant extracts to strict quality inspections free from heavy metals, pesticides or microbes before release to the clinics all over the world. The formulas and tinctures are assembled without fillers in small batches by a BHMA member herbal dispensary.
Nutraceutical DisclaimerThese statements have not been evaluated by the Food and Drug Administration or MHRA and the items are not intended to diagnose, treat, cure, or prevent any disease nor are they associated, endorsed, affiliated or sponsored by Anthony William, Medical Medium® Joe Tippens, Jane McLelland or Jim Gordon.
Melatonin is a CDK2 and CDK4 inhibitor for breast, gastro-intestinal, liver, ovarian, prostate, bone-cancer, melanoma & kidney cancer.
Melatonin reduces immunosenescence as characterized by reduced levels of peripheral naïve T cells derived from thymus and the loss of immature B lineage cells in the bone marrow.
Melatonin is a CDK2 and CDK4 (cyclin-dependent kinases) inhibitor and for breast, gastro-intestinal, liver, ovarian, prostate, bone-cancer, melanoma & kidney cancer through an increase in the p53/MDM2p ratio and downregulation of Sirt1.
Melatonin Suppresses the Growth of Ovarian Cancer Cell Lines (OVCAR-429 and PA-1) and Potentiates the Effect of G1 Arrest by Targeting CDKs
Focused Research Topics Melatonin & Breast Cancer
9. Hardeland R., Cardinali D.P., Brown G.M., Pandi-Perumal S.R. Melatonin and brain inflammaging. Prog. Neurobiol. 2015;127–128:46–63.