Our livers are being taxed harder than ever before, many factors determine whether our liver performs its critical functions well and can be helped with carefully selected nutrients often lacking within our diets.
Too much pressure on the liver from overeating rich or poor-quality food, environmental stresses, overwork or emotional stress can cause liver overload, leading to a decreased ability to clear toxins and hormones and manufacture bile and a host of illnesses such as Eczema, SIBO, Acne, Diabetes, Gall Stones, Bloating, Fatigue, Fatty Liver, Weight Issues, Adrenal Stress, Autoimmune Disease and much more.
Foods which contain high levels of antioxidants help to protect the liver and keep it healthy while other foods help the liver to metabolise toxins.
LivMagic™ is a comprehensive liver support formula containing:
Pure and Natural Ingredients – the only thing you’ll find in this is 30+ natural and high quality ingredients all in a vegan capsule.
No Artificial ingredients, Preservative Free and Non-GMO.
Gluten and Dairy Free.
Suitable for Vegetarians and Vegans.
The liver operates in two phases. Phase I and Phase II
Phase 1 uses many, many enzymes to break substances down. This phase as the ‘SUBTRACTION’ phase of metabolism, where the enzymes work to subtract molecules from substances and break them up into smaller more useful units, just like the process of food digestion does so in the gut. Phase 1 is utterly dependent on these ENZYMES, whose speed of metabolism is in turn affected by things like genetics, exercise and the presence or absence of certain substances/supplements in the diet that can either speed them up (induce them) or slow them down (inhibit them). After the enzymes have broken down some of the substances, some very toxic end products (metabolites) remain and they must quickly be shunted to phase 2 pathway in order to make them safer for the body to use. Heavy metals in particular can make these enzymes dysfunctional.
Phase 1 is carried out by the cytochrome P450 enzyme system and consists of oxidation and reduction reactions. Various nutrients are required in order for the Phase I detoxification system to be carried out efficiently. Cytochrome P450 reactions generate free radicals and this can cause secondary damage to cells. An adequate supply of key antioxidants is therefore essential to prevent tissue damage. Reduced glutathione, superoxide dismutase and additional nutrients such as beta carotene, vitamin E, selenium and N-acetyl-cysteine (NAC) will act as antioxidants. Other nutrient co-factors required for cytochrome P450 reactions include riboflavin, niacin, magnesium, iron and certain phytonutrients such as indoles from cruciferous vegetables and quercetin have been shown to support Phase I of liver detoxification.
Phase 2 is the ADDITION or CONJUGATION phase where new substances are added/conjugated to the toxic and good metabolites produced in phase 1 in order to make them
easier to transport, more stable and/or more functional for the body. You can think of the phase 2 pathways like you would seven conveyor belts in constant motion extending outwards from a central point, where the phase 1 pathways empty their byproducts. Specific substances are shunted towards a specific conveyor belt where particular enzymes are
available for the addition of a ‘special substance’ to create a new substance. Mostly these ‘special substances’ are amino acids like glycine and taurine, and other substances, like
glutathione, sulfate, and methyl. Each conveyor belt adds/conjugates a specific substance.
There are five main conjugation categories, including acetylation, acylation (peptide conjugation with amino acids), sulphur conjugations, methylations and conjugation with glucuronic acid.
Some substances enter Phase II detoxification directly, others come via Phase I pathways. During phase II detoxification, activated substances from phase I–otherwise known as
intermediates–are altered further.
Seven different major biochemical reactions occur in this phase, known as glutathione conjugation, amino acid conjugation, methylation, sulfation, acetylation, glucuronidation, and sulfoxidation. Each of these reactions works on specific types of intermediates and needs specific nutrients in order to proceed to successful completion. Basically, these reactions work by adding a molecule to the intermediate from phase I, making it less toxic and soluble in water.
Then the final product can be flushed out of the body in either the urine or the bile, another product of the liver. Bile leaves the body as part of solid waste. The nutrients required for phase II fall into two categories. The first are the amino acids, which donate molecules that are attached to phase I intermediates. These include the sulfur donors, among which are the amino acids methionine, taurine, cysteine, and N-acetylcysteine (NAC). Other, non-sulfur-containing amino acids are also required: glycine, taurine, glutamine, ornithine, and arginine. The antioxidant amino acid glutathione is also required for phase II detoxification.
The liver has a number of important functions, some of the main ones being:
* Detoxification of potentially toxic chemicals from both inside and outside of the body including drugs, alcohol and toxins from intestinal microbes. Accomplished with antioxidant nutrients and enzymes such as glutathione.
The liver detoxifies these harmful substances by a complex series of chemical reactions. The role of these various enzyme activities in the liver is to convert fat soluble toxins into water soluble substances that can be excreted in the urine or the bile depending on the particular characteristics of the end product.
*Storage of sugar as ‘glycogen’ and regulation of blood sugar levels.
*Production and storage of proteins as well as the regulation of many substances involved in protein metabolism.
*Production of bile which aids in the digestion of fats.
*Production of blood proteins, clotting factors and substances important to the production of red blood cells (erythrocytes)
*Regulation of a number of hormones.
*Neutralisation of ‘free-radicals’ by antioxidants. Free radicals are highly reactive oxygen molecules that can damage tissues.
*Storage of vitamins, mainly iron, copper, B12, vitamins A, D, E and K
*It plays an important role in digestion (breaking nutrients down)
*Involved with assimilation (building up body tissues).
* Red blood cells, which are responsible for carrying oxygen around the body, are recycled in the liver
The symptoms of a sluggish or overtaxed liver are varied and can include excess weight, liver and gall bladder diseases, headaches and migraines, digestive problems, allergies, immune system problems such as hay fever and asthma, food and chemical sensitivities, constipation, unexplained fatigue, skin itching and irritation, PMS and other menstrual problems.
Quality Assurance Declaration
Werone.co endeavors to use the most potent source materials within our formulas. Our herbal extracts are sourced and tested by the only Government-certified large scale producer of crude herb (powder-free) TCM concentrates in Asia who manufacture to GMP / ISO 9001/2000 pharmaceutical grade and also operate an ISO17025/TAF-certified laboratory where they subject all plant extracts to strict quality inspections free from heavy metals, pesticides or microbes before release to the clinics all over the world. The formulas and tinctures are assembled without fillers in small batches by a BHMA member herbal dispensary.
Nutraceutical DisclaimerThese statements have not been evaluated by the Food and Drug Administration or MHRA and the items are not intended to diagnose, treat, cure, or prevent any disease nor are they associated, endorsed, affiliated or sponsored by Anthony William, Medical Medium® Joe Tippens, Jane McLelland or Jim Gordon.