Enhance, protect and restore the function of your kidneys and bladder. Take this formula to nurture, cleanse and detoxify your kidneys and bladder and protect these organs from damage associated with inflammation, oxidation and infections.
KIDMagic™ formula has been prepared using the work of Travis Spire-Sweet, L.Ac. who compiled this article Renal Disease & Chinese Medicine where he outlines the safest most effective herbs known for use with Renal Diseases and other study-based information from Flavonoids in Kidney Health and Disease.
KIDMagic™ can be used alongside our RENALiV™ tincture.
Kidneys play a role in removal of toxic products from the body and maintain fluid, minerals and electrolyte balance at physiological level. But an elevated blood glucose level could be a prognostic factor for damage to the various segments of the nephron causing chronic kidney disorders . Other prior studies also strongly support that hyperglycemia poses higher risk of nephropathy [29, 30].
Flavonoids affect several renal factors that promote diuresis and natriuresis, which may contribute to their well-known antihypertensive effect. Flavonoids have been shown to prevent or attenuate the renal injury associated with arterial hypertension, both by decreasing blood pressure and by acting directly on the renal parenchyma. These outcomes derive from their interference with multiple signaling pathways known to produce renal injury and are independent of their blood pressure-lowering effects. Oral administration of flavonoids prevents or ameliorates adverse effects on the kidney of elevated fructose consumption, high fat diet, and types I and 2 diabetes. [source]
These compounds attenuate the hyperglycemia-disrupted renal endothelial barrier function, urinary microalbumin excretion, and glomerular hyperfiltration that results from a reduction of podocyte injury, a determinant factor for albuminuria in diabetic nephropathy.
Several flavonoids have shown renal protective effects against many nephrotoxic agents that frequently cause acute kidney injury (AKI) or chronic kidney disease (CKD), such as LPS, gentamycin, alcohol, nicotine, lead or cadmium. Flavonoids also improve cisplatin- or methotrexate-induced renal damage, demonstrating important actions in chemotherapy, anticancer and renoprotective effects. A beneficial prophylactic effect of flavonoids has been also observed against AKI induced by surgical procedures such as ischemia/reperfusion (I/R) or cardiopulmonary bypass.
In several murine models of CKD, impaired kidney function was significantly improved by the administration of flavonoids from different sources, alone or in combination with stem cells. In humans, cocoa flavanols were found to have vasculoprotective effects in patients on hemodialysis. Moreover, flavonoids develop antitumor activity against renal carcinoma cells with no toxic effects on normal cells, suggesting a potential therapeutic role in patients with renal carcinoma.
Useful Acupuncture Points:
Hiromi Yamamoto of Japan showed that acupuncture on two points, one located below knee and the other medial posterior to ankle (KD-3 and ST-36), decreased sympathetic nerve activity in the kidney . Dr. Brenner and Rector, leading nephrologist in the United States wrote “evidence from experimental studies indicated that sympathetic overactivity resulting from kidney disease may be accelerated in renal injury” and contributes to the progression of renal disease. (study)
Josne Paterno showed that the same two acupuncture points on the ankle and shin lowers serum creatinine, proteinuria, glomerular sclerosis and tubulointerstitial fibrosis indices. A secondary effect of one of the points studied above that may contribute to the shown effectiveness of acupuncture on CRF is the point below the shin. Stomach 36 (ST-36) when stimulated with acupuncture needles lowers blood pressure by modulating endothelial nitric oxide (eNOS) and neurona l nitric oxide (nNOS). ”
Studies Containing KIDMagic™ Ingredients:
Chinese Rhubarb (Rheum palmitum) Decreases protein urea, Scr, decreases severity of glomerulosclerosis, increases survival rate of chronic kidney disease, prevents progression of renal disease, decreases monocyte infiltration in glomeruli, inhibits proliferation of mesangial cells
Salvia miltiorrhizae: Tanshinone II(A), an active ingredient of Salvia has been found toDecreases proteinurea, glomerular sclerosis, tubular interstitial lesions, lowers BUN and Scr, inhibits ROS, increases serum SOD and catalase, ACEi, lowers blood pressure, increases atrial natriuretic peptide, increases renal blood flow. eNOS stimulation is one mechanism by which tanshinone induces vasodilation and reduces blood pressure. [source]
Quercetin: Quercetin downregulates the renal expression of epithelial Na+ channel (ENaC) in hypertensive Dahl salt-sensitive rats, and this effect is associated with a reduction in systolic blood pressure (Aoi et al., 2004). The ENaC plays a key role in the kidney, regulating Na+ reabsorption in renal tubules, and quercetin also stimulates the Na+-K+-2Cl− cotransporter 1 (NKCC1), a key ion transporter regulating cytosolic Cl− concentration (Marunaka, 2017). NKCC1 activation affects several body and cellular functions, such as renal Na+ reabsorption, thereby regulating the concentration and volume of extracellular fluid (Figure 2). Renal Na,K-ATPase is an important regulator of sodium homeostasis in the organism, and its activity is enhanced in spontaneously hypertensive rats (SHRs). Mezesova et al. (2010) reported that quercetin reduced Na,K-ATPase activity and affinity to the sodium binding site in both normotensive and hypertensive rats.
Silibinin / Milk Thistle: In vitro and in vivo studies have demonstrated the anticancer capabilities in renal cell carcinoma cells of silibinin, an antioxidant flavonoid extracted from milk thistle, which inhibited renal cell carcinoma growth through caspase-dependent apoptosis (Ma et al., 2015). In an in vivo mouse xenograft model, silibinin also reduced tumor growth, specifically targeting the mTOR-GLI1-BCL2 signaling pathway.
Galangal: Galangin, a flavonoid extracted from the root of Alpinia officinarum was reported to possess antiproliferative action and to inhibit renal cell carcinoma (786-0 and Caki-1) invasion by suppressing EMT, inducing apoptosis and producing ROS in renal carcinoma cells (Cao et al., 2016). Han et al. (2016) observed that the combination of galangin and TRAIL significantly induced apoptosis in renal carcinoma (Caki, ACHN, and A498) but not in normal mouse kidney cells or human normal mesangial cells, suggesting the potential utilization of galangin as a sensitizer of TRAIL-resistant cancer cell therapy. Meng et al. (2015) combined quercetin with anti-sense oligo gene therapy (Snail gene inhibition) and found that each suppressed the proliferation and migration of Caki-2 cells, inducing cell cycle arrest and apoptosis, with a strong suppression of renal carcinoma cells being achieved by their combination. Their findings supported this combination of natural product and gene therapy as a novel treatment for renal cancer.
Angelica Sinensis: The major ingredients of Angelica sinensis include ligustilide, n-butylidene phthalide, ferulic acid, nicotinic acid, and sesquiterpenoid compounds . These ingredients have been found to possess analgesic, anti-inflammatory, immunomodulatory, and even anticancer effects [31, 32]. Among them, ligustilide is the major active component of Angelica sinensis and has many pharmaceutical effects such as vasodilatation  and inhibition of the proliferation of vascular smooth muscle cells to retard vascular sclerosis . Therefore, Angelica sinensis may have beneficial effects on the progression of CKD and subsequently reduce the mortality of CKD patients. (source)
In addition to Angelica sinensis, the use of other (Renoprotective Chinese Herbal Medicines) RPCHMs was associated with a lower risk of all-cause mortality. Among the other RPCHMs evaluated in this study, Astragalus membranaceus is also commonly used in CHM. It is usually prescribed in conjunction with Angelica sinensis, a combination therapy that has been found to inhibit renal tubulointerstitial fibrosis in rats with obstructive nephropathy [19, 35].
Astragalus: Astragali radix exerted antifibrosis effects and were associated with improvements in ischemic microvasculature and renal interstitial fibrosis . Astragalus synergizes with Ferrulic acid from Angelica to alleviate renal tubulointerstitial fibrosis; this was associated with inhibition of tubular epithelial-mesenchymal transdifferentiation (EMT) and fibroblast activation, as well as an increase in NO production in the kidney. (source)
Epimedium: Icariin, a kidney-tonifying active flavonoid component of the Epimedium plant species, widely used in Chinese medicine, protected against renal function impairment and histological abnormalities secondary to chronic renal failure produced by 5/6 nephrectomy (Huang et al., 2015). Icariin also reduced TGF-β1 expression, increased CD24, CD133, Osr1, and Nanog expressions, and augmented the number of CD133(+)/CD24(+) renal stem/progenitor cells, considered responsible for these protective effects.
Suggested Usage & Dietary Considerations/ Concerns
Two capsules 3 times a day with warm filtered water on an empty stomach. Additional kidney support is achieved with higher fibre diet. This can be achieved by daily smoothies consisting of parsley and lemon, blended rather than juiced. Take activated charcoal 2 hours after meals to help bind toxins further supporting the kidneys.
Other Ingredients: (Capsule: Vegan HPMC, no fillers. There are a number of foods and herbs that are essential to AVOID with End Stage Renal Disease (ESRD), here’s a document from Travis with a list of them.
Other useful ingredients for Kidney support are Cordyceps/Reishi (capsules) and Rehmannia Tea .
Quality Assurance Declaration
Werone.co endeavors to use the most potent source materials within our formulas. Our herbal extracts are sourced and tested by the only Government-certified large scale producer of crude herb (powder-free) TCM concentrates in Asia who manufacture to GMP / ISO 9001/2000 pharmaceutical grade and also operate an ISO17025/TAF-certified laboratory where they subject all plant extracts to strict quality inspections free from heavy metals, pesticides or microbes before release to the clinics all over the world. The formulas and tinctures are assembled without fillers in small batches by a BHMA member herbal dispensary.
Nutraceutical DisclaimerThese statements have not been evaluated by the Food and Drug Administration or MHRA and the items are not intended to diagnose, treat, cure, or prevent any disease nor are they associated, endorsed, affiliated or sponsored by Anthony William, Medical Medium® Joe Tippens or Jim Gordon.
Shenkang granules (SKGs) are a Chinese herbal medicinal formula used for Chronic renal failure (CRF), consisting of rhubarb (Rheum palmatum L.), Salvia miltiorrhiza, Astragalus membranaceus Root and safflower (Carthamus tinctorius L.). SKG may increase the removal of toxicity products, remove oxygen free radicals and reduce the free radical-induced damage of kidney tissues & markedly reduce the serum concentration of TGF-β subsequently improving renal function.