IVERMIDE – Anti-CSC, Kill-Shot Formula

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IVERMIDE™ formula has been designed to initiate the kill-shot after staving cells for a few months, it contains anthelmintics Ivermectin (4mg), Niclosamide (100mg), 50% EGCG (100mg) from Green Tea, Modified Citrus Pectin(100mg) & Alpha Lipoic Acid (100mg) which increases free radicals and oxidative species to help make weak cells unviable and initiate the natural apoptosis cytochrome C release mechanism which causes cell suicide.

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Description

The fuel inhibition strategy which many employ using the range of BiohackIT ‘MFIS’ products, which are used to starve tumor cells of their fuel supplies of Glucose, Glutamine and Fatty Acids. After a number of months of this process there is an opportunity to strike a fatal blow to the weakened tumor cells for a couple of days a week by damaging their DNA with a more specific formula which causes free radicals , increases oxidative stress levels & may trigger cell death.
[pubmed 28847725]

IVERMIDE™ formula has been encapsulated for this purpose containing anthelmintics Ivermectin (4mg) & Niclosamide (100mg) with EGCG (100mg) from Green Tea, Modified Citrus Pectin(100mg) & Alpha Lipoic Acid (100mg) which increases free radicals and oxidative species to help make weak cells unviable and initiate the natural apoptosis cytochrome-C release mechanism which causes cell suicide.

 


View Labtests.
Niclosamide (99.2%), Ivermectin(98.1%),


Ivermectin

Renal cell carcinoma (RCC) is one of the most aggressive types of cancer and highly resistant to current available therapies. In this [study], Yangtze University in China investigated the effects and mechanism of anti-parasitic agent ivermectin in RCC. They showed that ivermectin significantly inhibits proliferation and induces apoptosis in multiple RCC cell lines that represent different histological subtypes and various mutation status. Importantly, ivermectin is significantly less or ineffective in normal kidney cells compared with RCC cells, demonstrating the preferential toxicity of ivermectin to RCC. Ivermectin also significantly inhibits RCC tumor growth in vivo.

Mechanistically, ivermectin induces mitochondrial dysfunction via decreasing mitochondrial membrane potential, mitochondrial respiration and ATP production. As a consequence of mitochondrial dysfunction, oxidative stress and damage is detected in ivermectin treated RCC cells and xenograft mouse model. Compared to normal kidney cells, RCC cells have higher mitochondrial mass and respiration, and ATP production, which might explain the preferential toxicity of ivermectin to the tumor cells. Their work suggest that ivermectin is a promising candidate for RCC treatment and targeting mitochondrial metabolism is an alternative therapeutic strategy for RCC. As in the above study, ivermectin in this model also decreased mitochondrial membrane potential as well as basal and maximal respiratory capacities. Of note, ivermectin significantly increased intracellular ROS and 8-OHdG levels, suggesting that the antitumoral effects of ivermectin are related to oxidative stress and DNA damage.

Niclosamide

Niclosamide, the salicyclamide derivative, is an oral anti-helminthic drug to treat tapeworm infections. In addition to be used as an anti-infective agent afterward, it has been demonstrated to exhibit anti-cancer activity in several cancers such as colorectal cancer (Sack et al., 2011), ovarian cancer (Yo et al., 2012), acute myeloid leukemia (AML) (Jin et al., 2012), and breast cancer (Wang et al., 2013). Niclosamide targets multiple signaling pathways which are closely involved with oncogenesis and oncoprogression such as NF-κB, Wnt/β-catenin, Notch, and mTORC1 (Pan et al., 2012).

Niclosamide targets the Wnt co-receptor LRP6 on the cell surface and that it is potent molecule as a Wnt/β-catenin signaling and anti-cancer agent for human prostate and breast cancer due to in vitro studies (Lu et al., 2011).

EGCG

The chemopreventive effects of green tea have been attributed to polyphenolic ingredients that have potent antioxidant properties. Among many polyphenolic compounds isolated from green tea, (-)-epigallocatechin gallate (EGCG) is recognized as a key active constituent in terms of cancer chemopreventive potential. It is reported that 1.0 × 10-4 M EGCG can significantly inhibit the growth of acute myeloblastic leukemia cells and induce apoptosis in human cancer cells [,]. Although cancer cell lines exhibit variable sensitivity to EGCG [], EGCG is more and more seen as a possible new tumor-suppressing and anti-carcinogenic natural chemical. Many studies showed that EGCG inhibited the survival rate of malignant cells and induced apoptosis of malignant cells via the mitochondrial signal transduction pathway [,]. Roy et al. [] reported that the increased ratio of Bax/Bcl-2 proteins after EGCG treatment might result in increased release of cytochrome C from mitochondria into cytosol, increase the expression of Apaf-1, and activate caspase-3 and poly (ADP-ribose) polymerase, which could lead to apoptosis in MDA-MB-468 cells.

Modified Citrus Pectin

Modified citrus pectin fights cancer metastases. This makes it potentially one of the most important substances in the complementary arsenal against cancer. MCP is a chemically altered form of pectin, a substance that is familiar to most cooks. Pectin is naturally found in ripe fruit, including apples and citrus. It is best known for its use as a thickening agent for jams and jellies. But, to be clear, taking supermarket pectin will not have the desired medicinal effects. That is because ordinary pectin contains highly complex polysaccharides, which cannot be digested in the human gastrointestinal (GI) tract. In other words, the substance that helps pectin fight cancer need to first be broken down through a combination of heat and acid to yield the purified medicinal product, called MCP.

MCP has some powerful biochemical effects. In particular, it blocks the action of a substance called galectin-3. Galectin-3 is not your friend. In fact, it promotes tumor growth and progression, as well as new blood vessel growth in the laboratory. Blocking galectin-3 is one of the main ways that modified citrus pectin fights cancer.

There are presently almost 100 articles in PubMed on the topic of MCP. Almost half of these concern its ability to fight cancer. Although most of these are laboratory studies, in test tubes or animals, taken together they constitute a picture of MCP as a very promising item. In the laboratory, MCP blocks the migration of wandering cancer cells.

Ingredients:

IVERMIDE™ Ingredients per 2x Vegan Capsules
Niclosamide (5‐chlorosalicylic acid) (†) 200mg *
EGCG (50% epigallocatechin gallate)(†) 200mg *
Modified Citrus Pectin – MCP (Pectasol™) (†) 200mg *
Alpha Lipoic Acid (†) 200mg *
Ivermectin(†) 8mg *
Black Pepper 20mg *
Other ingredients: HPMC Hypromellose (vegetable capsule), zero fillers, (†) Lab-Tested, * Daily value not established

Suggested Usage

For the kill phase, take 1-2 capsules with a little BIOFUZE™ in water 3x/day after food or as directed by a health professional. It may also be suitable as an adjuvant.  IVERMIDE™ may best be supported with  FASNHIB™ for Fatty Acid inhibition  & GLUTAHIB™ metabolic fuel supply inhibiting formulas,  CURCUBOS™,  CURCUMEL™,  OMEGA DHA™, and a ZERO Sugar/Fat Diet with regular cruciferous vegetables (SULFORAPHANE).  The  180 capsule versions may be more suitable for this.  BIOFUZE™ increases the absorption of this supplement into the cells improving efficiency.  Increase the dosage and frequency if you are at a later stage in your condition.

When tumor cells die off, there can be associated nausea and other die-off symptoms which can be very toxic. Make sure that you assist the detoxification pathways of these toxins by supporting the liver with clean water, Glutathione, Magnesium, Selenium, Charcoal, Melatonin,  Epsom Salt baths, Infra-Red saunas and hot/cold hydrotherapy showers to move the lymphatic system.

Ivermectin Safety

There are several toxicological reports of ivermectin in different species. The lethal dose 50 (LD50) reported in dogs it is 80 mg/kg administered orally  which is 2.0g for a 60kg human. In this study they found 50% reduction in tumor growth with very low dosage of about 8mg/ day, for our formula we will be using 4mg so that you can safely use it twice or 3 x a day up to about 6 or 12 capsules max (48mg Ivermectin), this is for someone around 60kg in body weight. At around 400mg to 900mg  (100 to 200 capsules), Ivermectin can become quite toxic for humans, so we are working 10x LOWER than the potential organ failure dosage levels.

In humans it is considered that ivermectin generates low levels of toxicity because its targets are confined within the CNS. Indeed, most patients treated with ivermectin have no side-effects other than those caused by the immune and inflammatory responses against the parasite, such as fever, pruritus, skin rashes and malaise, and when present, they appear within 24-48 h after treatment . Certainly, moderate symptoms such as arthralgia, dizziness, fever, skin edema, dyspnea and hypotension may be more related with the microfilarial load in the patient rather than with the intrinsic toxicity of ivermectin . Reports on cases of encephalopathy in patients co-infected with onchocerciasis and lymphatic filariasis after 48 h of treatment with ivermectin can be found in the literature , but it is believed that this adverse reaction is due to the obstruction of the microcirculation of the brain by the accumulation of dead or paralyzed parasites, which leads to brain embolism .

Drug Interactions:  Moderate Drug interactions may occur , see this page for the actual drugs.

Dosage Limits
The IVERMIDE™ capsule contains 4mg so that you can safely use it twice or 3 x a day up to about 6 or 12 capsules max (48mg Ivermectin). This is for someone around 60kg in body weight.

 

Quality Assurance Declaration

Lab-Tested
Werone.co endeavors to use the most potent source materials within our formulas. Our herbal extracts are sourced and tested by the only Government-certified large scale producer of crude herb (powder-free) TCM concentrates in Asia who manufacture to GMP / ISO 9001/2000 pharmaceutical grade and also operate an ISO17025/TAF-certified laboratory where they subject all plant extracts to strict quality inspections free from heavy metals, pesticides or microbes before release to the clinics all over the world. The formulas and tinctures are assembled without fillers in small batches by a BHMA member herbal dispensary.

 

Nutraceutical Disclaimer

These statements have not been evaluated by the Food and Drug Administration or MHRA and the items are not intended to diagnose, treat, cure, or prevent any disease nor are they associated, endorsed, affiliated or sponsored by Anthony William, Medical Medium® Joe Tippens, Jane McLelland or Jim Gordon.

 

Clinical References

The multitargeted drug ivermectin: from an antiparasitic agent to a repositioned cancer therapy.
https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5835698/

Antibiotic ivermectin preferentially targets renal cancer through inducing mitochondrial dysfunction and oxidative damage
https://pubmed.ncbi.nlm.nih.gov/28847725/

Multi-targeted therapy of cancer by niclosamide: a new application for an old drug
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166407/

Modified Citrus Pectin as a Potential Sensitizer for Radiotherapy in Prostate Cancer
https://pubmed.ncbi.nlm.nih.gov/30043669/

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