Tumor cells don’t just use glucose/sugar as their only source of fuel, especially when we may be restricting sugars because we heard that tumor cells only consume sugars, but this is a half truth. Glucose is usually their primary fuel source, however, when it’s not available such as when being restricted by FENBENCUR™ or FLUBENCUR™ and/or in late stage progression, the tumor cells have devised an ingenious way of changing their metabolism to grab fuel from three other sources: Glutamine (proteins) , Fatty Acid Synthesis (FASN) & Autophagy.
These 3 main fuel pathways exploited by Tumors are the strategy for using Re-purposed drugs such as Metformin, Doxycyline, Dipyridamole, Niclosamide, Aspirin and a statin to target and inhibit these pathways which drive the TCA cycle within each tumor cell with the aim of to weakening it over time.
However, should you have difficulty being prescribed the drugs described, we have developed a herbal formula which aims to target similar Glutamine Synthesis pathways of: Glutamine OXPHOS, Macropincytosis, Nuceleoside Salvage, Glutaminolysis and Insulin Growth Factor which we have named GLUTAHIB™.[To better understand these concepts, See our MFI Strategy here – Werone Private Herbal Health Trust Members only]
GLUTAHIB™ is a broad-based nutraceutical formula containing herbal extracts and other nutrients which have individually been shown to reduce glutamine availability. [source]. Our other formula FASNHIB™, is aimed at inhibiting Fatty Acid Synthesis uptake by cells.
“It’s been known since 1923 that tumor cells use a lot more glucose than normal cells. Our research helps show how this process takes place, and how it might be stopped to control tumor growth,” says Don Ayer, Ph.D., a Huntsman Cancer Institute investigator and professor in the Department of Oncological Sciences at the University of Utah.
Glucose and glutamine are both essential for cell growth, and it was long assumed they operated independently, but Ayer’s research shows they are inter-dependent. During both normal and cancerous cell growth, a cellular process takes place that involves both glucose (sugar) and glutamine (an amino acid). Ayer discovered that by restricting glutamine availability, glucose cannot be well utilised by cancer cells. “Essentially, if you don’t have glutamine, the cell is short circuited due to a lack of glucose, which halts the growth of the tumor cell,” Ayer says.
So as well as choosing supplements which help target various oncogenes and tumor surpressors, the other aspects driving the Tumor is metabolic syndrome, this is how the Tumor gets it’s fuel, when you starve the cells and weaken them, you can then go in for the kill and be more effective than attacking strong growing Tumor cells.
Preferential exploitation of aerobic glycolysis by Tumor cells is a key issue of reprogrammed metabolism. It is becoming clear that other metabolic pathways or mediators may play a fundamental role in Tumors. The availability of recent sophisticated experimental approaches to study the metabolic profile of Tumor cells has allowed identification of an impressive number of alterations. They essentially concern levels of expression/accumulation or status of enzymes or intermediate substrates involved in several anabolic pathways.
Glutamine can play a critical role in cellular growth in multiple tumors. Glutamine-addicted tumor cells are dependent on glutamine for viability, and their metabolism is reprogrammed for glutamine utilisation through the tricarboxylic acid (TCA) cycle via glutaminolysis. The ratio of gene expression associated with glutamine anabolism versus catabolism has emerged as a novel biomarker for patient prognosis. Significantly, glutamine regulates the activation of STAT3, a mediator of signaling pathways which regulates hallmarks in various tumor cells. It is now clear that a combined approach of targeting high-invasive tumor cells by blocking glutamine’s entry into the TCA cycle, along with targeting low-invasive tumor cells by inhibiting glutamine synthesis and STAT3 blocking (with Flubendazole, Melatonin, Egamma & Graviola) may be a useful therapeutic approaches.
The following diagram shows the specific metabolic pathways which the BiohackIT herbal formulas seek to inhibit.
Take 2-3 x caps with water in the morning after food (if not fasting), 2-3 x Caps after lunch and 2-3 x Caps in the evening after food or as directed by your health professional. For greater effect, increase the dosage. GLUTAHIB™ may best be supported with FASNHIB™ Fatty Acid metabolic fuel supply inhibiting formula, EGAMMA™, AUTOPHIB™, CURCUBOS™, FENBENCUR™, CURCUMEL™, ZERO Sugar/Fat Diet, METFORMIN, LD/ASPIRIN and/or STATIN, DIPYRIDAMOLE & MILDRONATE.
(Avoid White Rice, Sunflower, Sesame, Olive Oils & Flax-oils when using statins otherwise they can be defeated, see dietary caution on FASNHIB page.)
GLUTAHIB™ may be made more effective by combining with intermittent fasting. It is also possible that in the beginning low energy levels and altered immune T-cell response may be experienced, this may improve over a period of days/ weeks, weight-loss may also be experienced.
Berberine Note: Berberine HCL content is 8% of the Coptis extract, therefore 2 capsules = 80mg Berberine HCL and may not need to be pulsed as you would with a pure Berberine isolate.
Quality Assurance Declaration
Werone.co endeavors to use the most potent source materials within our formulas. Our herbal extracts are sourced and tested by the only Government-certified large scale producer of crude herb (powder-free) TCM concentrates in Asia who manufacture to GMP / ISO 9001/2000 pharmaceutical grade and also operate an ISO17025/TAF-certified laboratory where they subject all plant extracts to strict quality inspections free from heavy metals, pesticides or microbes before release to the clinics all over the world. The formulas and tinctures are assembled without fillers in small batches by a BHMA member herbal dispensary.
Nutraceutical DisclaimerThese statements have not been evaluated by the Food and Drug Administration or MHRA and the items are not intended to diagnose, treat, cure, or prevent any disease nor are they associated, endorsed, affiliated or sponsored by Anthony William, Medical Medium® Joe Tippens, Jane McLelland or Jim Gordon.
THE EMERGING HALLMARKS OF CANCER METABOLISM (2016)
Tumor Glutamine Addiction