BiohackIT BCHIB™ is a broad-based nutraceutical formula containing herbal extracts and other nutrients which have been shown to reduce inflammation and reduce the gene-mutational drivers of various types of breast tumors including TNBC
BCHIB™ is a capsule adjuvent formula containing eight ingredients shown and other nutrients containing; Genistein, Turkey Tail Extract (Coriolus) , Skullcap ( S.Barbata), Oldenlandia (Hedyotis), Ginger, Broccoli Sprout Extract, Holy Basil Extract, Astragalus, & organic black pepper and may be best used alongside a strong metabolic fuel inhibition strategy ‘MFI’.[To better understand these concepts, See our MFI Strategy here – Werone Private Herbal Health Trust Members only]
Tumors acquire persistent changes in metabolism during disease development and may become metabolite addicted, which can be exploited in tumor therapy. For example, breast tumors commonly develop a lipogenic phenotype and heavily rely on glucose and glutamine consumption for tumor growth. This reprogramming of cell metabolism in breast tumors are facilitated by oncogenes and tumor suppressor genes and both catalytic and noncatalytic roles of enzymes.
Both pathways are prospective targets in breast tumor therapy. Aerobic glycolysis metabolizes glucose to provide cells with acetyl-CoA and NADPH that are required for the synthesis of larger molecules such as lipids, proteins, and nucleic acids. Moreover, acetyl-CoA induces cell growth by directly affecting acetylation of histones that encode growth-related genes, leading to increased transcription of these genes. Aerobic glycolysis bypasses mitochondrial oxidative phosphorylation (OXPHOS) to avoid an unbalanced and detrimental overproduction of ATP and NADH.
Aerobic glycolysis also produces large quantities of lactate to regenerate and maintain an essential NAD+ pool. Lactate is secreted into the tumor microenvironment where it acidifies the extracellular space, increases angiogenesis, and modulates phenotypes of stromal cells in support of continuous tumor growth.
Like glucose, glutamine is taken up by tumor cells and has a crucial role in the replenishment of the mitochondrial citric acid carbon pool. Glutamine is converted into glutamate, which is a precursor for glutathione. It is also a source for the synthesis of other amino acids and a-ketoglutarate, a tricarboxylic acid (TCA) cycle intermediate which is used as the main energy supply and is the metabolic target of our Metabolic Fuel Inhibition strategy (MFI). Glutaminolysis may directly feed into the TCA cycle but it can alternatively be used to feed into a process termed reductive carboxylation of glutamine-derived a-ketoglutarate that constitutes a partial reverse of the TCA cycle to support citrate and fatty acid synthesis in stress situations such as hypoxia.
In addition, mitochondrial glutamine may serve as a source for energy synthesis in breast tumors. Glutamine restriction slows the growth of most breast tumor cells and targeting the activity of mitochondrial glutaminase, a key enzyme in glutamine metabolism, induces growth arrest and apoptosis, especially among breast tumor cells with the triple-negative phenotype.
Agents for inhibition: Curcumin, Holy Basil & Oldenlandia (Ursolic Acid )
The enzyme phosphoglycerate dehydrogenase (PHGDH) is a novel oncogene that is frequently amplified in ER-negative breast tumors. Increased expression of PHGDH facilitates the diversion of glycolytic carbon into serine and glycine metabolism. Alternatively, knockdown of PHGDH inhibits cell growth, indicating that this pathway is a candidate therapeutic target in breast cancer. The SiteMap calculation performed by Angelo et al. predicted the binding of curcumin to NAD+ binding site on PHGDH, which is crucial for PHGDH enzymatic activity. The curcumin binding enzymes, PHGDH and SHMT2, belong to the serine-glycine metabolic pathway. Both amino acids, serine and glycine, serve as intermediates for the biosynthesis of other amino acids, nucleic acids and lipids. [source]
Further, mitochondria can switch their metabolic phenotypes to meet the challenges of high energy demand and macromolecular synthesis [source]. Thus, tumor mitochondria have the ability to flexibly switching between glycolysis and oxidative phosphorylation (OXPHOS) for their survival. [source]
By targeting these two main fuels known as a Double-Hit approach, we have developed NICLOSTEM™ which includes a number of ingredients such as Ginger, Silimarin, Olive Leaf Extract and Sulforaphane from Broccoli Sprout extract which are shown to inhibit key metabolic processes such as OXPHOS, Glycolysis, WNT and HDAC , which when combined with Glutamine [GLUTAHIB] and Fatty Acid Inhibitors [FASNHIB] should cause fuel starvation and stress to CSC’s. The additional inclusion of mushrooms Shitake and Coriolus (Turkey Tail) in BCHIB and Niclostem could help to improve T Cell immune response.
BCHIB™ may be used as an adjuvant to standard care, and as part of a metabolic fuel-blocking approach along with FASNHIB™, GLUTAHIB™ to inhibit metabolic fuel supply and also with MEBENGRAV™ to activate caspases for the kill phase.
Metabolic Fuel Inhibition Strategy (MFI)
These 3 main metabolic fuel pathways exploited by Tumors may be targeted using re-purposed drugs such as Metformin, Doxycyline, Dipyridamole, Niclosamide, Aspirin and a statin to target and inhibit these pathways which drive the TCA cycle within each Tumor cell with the aim of to weakening it over time. MBZ also interferes with VEGF kinase by competing with ATP which is the energy used within the TCA Cycle of every cell.
Take 2-3 capsules with a little alcohol 2-3x/day after food or as directed by a health professional. May be suitable as an adjuvant. BCHIB™ may be supported with FLUBENCUR™, CURCUMEL™, VBLOCK™ , MEBENGRAV™, GLUTAHIB™ &FASNHIB™ MFI-inhibiting formulas, CURCUBOS™, OMEGA DHA™, and a ZERO Sugar/Fat Diet with regular cruciferous vegetables (SULFORAPHANE). For synthetic chemotherapeutic alternatives consider: METFORMIN, LD/ASPIRIN and/or STATIN, NICLOSAMIDE & DIPYRIDAMOLE .
Quality Assurance Declaration
Werone.co endeavors to use the most potent source materials within our formulas. Our herbal extracts are sourced and tested by the only Government-certified large scale producer of crude herb (powder-free) TCM concentrates in Asia who manufacture to GMP / ISO 9001/2000 pharmaceutical grade and also operate an ISO17025/TAF-certified laboratory where they subject all plant extracts to strict quality inspections free from heavy metals, pesticides or microbes before release to the clinics all over the world. The formulas and tinctures are assembled without fillers in small batches by a BHMA member herbal dispensary.
Nutraceutical DisclaimerThese statements have not been evaluated by the Food and Drug Administration or MHRA and the items are not intended to diagnose, treat, cure, or prevent any disease nor are they associated, endorsed, affiliated or sponsored by Anthony William, Medical Medium® Joe Tippens, Jane McLelland or Jim Gordon.