Of the 13 vitamins our bodies need, one of the hardest to get as a vegan is Vitamin B12. It is unique because it is the only vitamin that cannot be obtained from plants or sunlight (as plants do not need B12, so do not produce or store it), it is produced by bacteria in the gut of animals and absorbed in the small intestine.
B12BIACTIVE™ is now supplied with Organic Vegetable Glycerin to help protect the B12 from gastric juices and also a Pipette, enabling 2798mcg with just 2 droppers (2 x single press of the pipette) and is probably the lowest cost per serving at £0.66/srv with the 100ml bottle, see below table (when using the Werone Loyalty Rewards Scheme)
Note: Our 30ml B12Biactive™ at £24.50 is comparable with Vegansafe™ 29ml normally retailing at £27.99 and Vimergy Liquid B12™ retailing at £26.00, representing a saving of £3.49 and even more savings if getting the 50ML or the 100ml B12Biactive™, please see the below table to compare.
It is remarkably easy to become deficient in B12, as many people can neither absorb nor use B12 due to gut disturbances. Vegans and vegetarians are particularly prone to deficiency. The route that B12 takes from the mouth to the blood is very complex and there can be problems at any point. Which is why sublingual administration can be very effective as it enters directly into the bloodstream.
A well-known health author said of soluble B12 in an interview here:
” A supplement that’s very important for the population is B12, in the form of adenosylcobalamin combined with methylcobalamin or hydroxycobalamin. This type of B12 blend has yet to gain much popularity, because very few people know about it. I only know because I am blessed that Spirit is ahead of the times in order to get people what they need. Mark Spirit’s words, this form of B12 will be in every naturopathic doctor’s repertoire before too long. We live in a time of more stress and pollution than ever before in history, and Spirit tells me that wild blueberries and B12 (as an adenosylcobalamin blend) are two of the most important secrets to surviving in the 21st century”.
B12BIACTIVE™ contains lab-generated forms of B12… Methylcobalamin(80%) and Adenosylcobalamin(20%)
Therefore to obtain B12 from the diet you need to eat animal products- meat, fish or dairy products. However even a diet high in these foods may not supply enough B12. In fact it is remarkably easy to become deficient in B12 as many people can neither absorb nor use B12. Vegans and vegetarians are particularly prone to deficiency. The route that B12 takes from the mouth to the blood is complex and there can be problems at any point.
Metabolic Effects of B12 :
- Reduces Tiredness
- Supports Nervous System
- Assists Blood Formation
- Supports Proper Cell-Division
- Helps Homocysteine metabolism along with Folate (5MTHF)
The steps of the B12 pathway are:
- Food containing B12 is bound to animal proteins and needs to be freed. So when the food reaches the stomach it is split by an enzyme Pepsin (produced in the stomach only if sufficient amounts of Hydrochloric acid)
- The stomach also produces intrinsic factor (IF), a protein that is needed later in the pathway.
- Other proteins known as R-Binders carry the B12 into the small intestine.
- In the intestine, intrinsic factor (from the stomach ) attaches itself to the B12 and transports it to the last section of small intestine, the ileum. The cells lining the ileum contain receptors that grab onto the B12-Intrinsic factor complex and drag it into the blood stream
- In the bloodstream, another protein, transcobalamin2 carries the Vitamin B12 to all the cells in the body, transporting any extra to the liver for storage.
The most-commonly used man-made forms are cyancobalamin, methylcobalamin, and hydroxocobalamin. Hydroxycobalamin is the form of vitamin B12 that the “good” or “healthy” bacteria in your gut make on their own.
Methylcobalamin is the form of vitamin B12 that’s the easiest for the body to use. Methylcobalamin is optimally bioeffective. Adenosylcobalamin plays a critical role in mitochondria, methylation tolerance, myelin formation, and neurological health and is often lacking in the diet.
The most well studied use of methylcobalamin has to do with sleep. Although the exact mechanism of action is not yet clear, it is possible that methylcobalamin is needed for the synthesis of melatonin. Available information indicates that methylcobalamin can modulate melatonin secretion, enhance light-sensitivity, and normalize circadian rhythm (your 24-hour clock). Because of this, individuals supplementing this form of B12 often have improved quality of sleep, often will require slightly less sleep, and will not uncommonly report that they feel a bit more refreshed when waking in the morning. Methylcobalamin is particularly effective when your 24-hour clock is not running smoothly.
Adenosylcobalamin is also an “active” B12 form, making this coenzyme immediately available for use by the body. It is required for an enzyme known as MCM (Methylmalonyl Coenzyme A Mutase), which resides in the mitochondria and is needed to make succinyl CoA to produce energy in the citric acid cycle. In humans adenosylcobalamin is found mainly in the tissues especially the liver. It is the primary form on B12 found in non-human animals. Deficiency of Vitamin B12 There is no one particular symptom that suggests a B12 deficiency. Symptoms may depend on the age and genetic disposition of the individual, and also the length and severity of deficiency.
Because Vitamin B12 has so many functions, including the health of nerves, brain, blood and immune system, as well as the formation of DNA, B12 deficiency can impair functioning in almost any part of the body. The following signs and symptoms are common symptoms of B12 deficiency but can also arise from other causes. Mental changes include irritability, apathy, sleepiness, paranoia, personality changes, depression, memory loss, dementia, hallucinations, violent behaviour and in children developmental delay and/or autistic behaviour.
Neurological signs and symptoms include pain, tingling or numbness, decreased sense of touch, pain or temperature, weakness, loss of awareness of body position, clumsiness, tremor, symptoms mimicking Parkinson’s disease or multiple sclerosis, spastic muscles, incontinence, paralysis, visual changes and damage to the optic nerve.
Vascular changes include, transient ischaemic attacks (TIAs or mini strokes), CVA or stroke, coronary artery disease, heart attack, congestive heart failure, palpitations, low blood pressure when standing causing fainting, deep vein thrombosis (blood clot in the arm or leg) and pulmonary embolism.
Other signs and symptoms may include shortness of breath, generalized weakness, chronic fatigue or tiredness, loss of appetite and weight loss, epigastric pain (poor digestion, full or bloated feeling after eating normal or small meals), diarrhoea or constipation, increased susceptibility to infection, poor wound healing, failure of new born to thrive, tinnitus, vitiligo (white patches of skin), or hyper-pigmentation, premature grey hair and impotence.
We now have a pipette to make higher dosages much easier, eg: 2 x pipette squeezes = approximately 2798 mcg (48,632%).
You can order a pipette for your bottle (to replace your spray nozzle) on this page.
It is advisable that B12 is NOT to be taken with fruit juice or with Vitamin C supplements (see below).
Using the pipette, squirt 2 x pipette squeezes of B12BIACTIVE™ under the tongue and hold for 30 seconds before swallowing. Do not try to completely fill the pipette, this will create an inaccuracy, just one press of the pipette bulb fills approx half way up the pipette, do this twice and you will have 2798mcg.
30ML B12BIACTIVE™ will last approx 22 days (2 droppers per day – 2798mcg /62 drops / 48,632 %DV )
50ML B12BIACTIVE™ will last approx 37 days(2 droppers per day – 2798mcg /62 drops / 48,632 %DV )
100ML B12BIACTIVE™ will last approx 74 days (2 droppers per day – 2798mcg /62 drops / 48,632 %DV )
Note: Our B12 is derived from a non-GMO fermentation process and is tested for 100% purity and is free from toxins and free from citric acid.
|SUPPLEMENT FACTS – 100ML|
|Serving Size: Serving Size: 2 x droppers /day (62 drops)
Servings Per Container: 74
% Daily Value
Amount Per Serving: 2798mcg
Other ingredients: Organic Vegetable Glycerin (coconut-derived) & Purified Water.
† % Daily value not established.
All forms of B12 are stable when protected from the light. Light exposure cleaves the cyanide with the production of hydroxycobalamin. The B12’s have an optimal stability at a PH4.00-4.5, even at higher temperatures. In the presence of acid or alkaline mediator the presence of reducing agents such as ascorbic acid the vitamin is destroyed to a greater extent.
It is therefore advisable that B12 is not to be taken with fruit juice for at least 1 hour afterwards.
Suggested Use: Hold under the tongue for 30secs. Take on empty stomach first thing AM, 1 hour before Vit C
Note: After opening keep refrigerated, potency is maintained for up to 3 months from opening.
Quality Assurance Declaration
Werone.co endeavors to use the most potent source materials within our formulas. Our herbal extracts are sourced and tested by the only Government-certified large scale producer of crude herb (powder-free) TCM concentrates in Asia who manufacture to GMP / ISO 9001/2000 pharmaceutical grade and also operate an ISO17025/TAF-certified laboratory where they subject all plant extracts to strict quality inspections free from heavy metals, pesticides or microbes before release to the clinics all over the world. The formulas and tinctures are assembled without fillers in small batches by a BHMA member herbal dispensary.
Nutraceutical DisclaimerThese statements have not been evaluated by the Food and Drug Administration or MHRA and the items are not intended to diagnose, treat, cure, or prevent any disease nor are they associated, endorsed, affiliated or sponsored by Anthony William, Medical Medium® Joe Tippens, Jane McLelland or Jim Gordon.