AUTOPHIB™ – Autophagy Blocking, Pain Relieving Formula

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AUTOPHIB™ is a capsule formula containing three ingredients shown to inhibit Autophagy and also reduce neuropathic & spinal pain;  Palmitoylethanolamide (PEA) , Luteolin (from Pagoda flower) and Capsaicin from Capsicum.

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Description

When fasting, avoiding sugar or using Fenbendazole, Flubendazole, Mebendazole, Berberine, Green Tea etc, tumor cells will start to scavenge nutrients by breaking down cells to recycle them as fuels, survive microenvironmental stress and to increase growth and aggressiveness (source) in a process known as Autophagy.

It’s normally a good thing to activate autophagy to prevent tumors, however, with established tumors, it’s one of the ways they get fuel when the glucose is being restricted so Autophagy is an innevitable reality when restricting calories, and so blocking Autophagy becomes an important strategy to add to Fat and Glutamine blocking, and that’s why we have developed AUTOPHIB™.

Some of the  Autophagy-related pathways are:
BECLIN1, mTOR, LC3, ATG5-7, ULK1, FOXO, PI3k/AKT 

Even though many of our favourite anti-tumor supplements which inhibit mTOR and PI3k/AKT such as Curcumin, Green Tea, Metformin, Berberine, Quercetin & Fenbendazole activate Autophagy we still need to use them but need a mechanism to override their ability to activate Autophagy.

Autophagy is an essential survival pathway during nutrient or growth factor deprivation, and genetic studies demonstrate that it contributes to some forms of tumors in mice. However, because autophagy supplies amino acids through protein degradation, it does not serve as a source of net protein synthesis. It is also potently suppressed by mTORC1.

Additionally as we re-instate P53 Tumor Suppressor function and it’s response to stress with Fenbendazole, Flubendazole and Mebendazole we also activate Autophagy  via (DRAM)29, Sestrin230, Bcl-2-associated X protein (Bax) and p53-upregulated modulator of apoptosis (PUMA)31 (source).

There are an abundant amount of Autophagy-activating nutraceutical agents but very few which actually block this process, which is one reason that Autophagy is normally very active. Fortunately work in the area of Neural inflammation has identified a number of quite potent autophagy-blockers. These also can have the very useful side effects of reducing pain.


View Labtests. PEA (98.7%), Luteolin(98.34%).


AUTOPHIB™ is a capsule formula containing three ingredients shown to inhibit Autophagy and also reduce neuropathic & spinal pain;  Palmitoylethanolamide (PEA) , Luteolin (Pagoda flower) and Capsaicin from Capsicum.

Palmitoylethanolamide (PEA) is a biologically active, endogenous lipid that is widely distributed throughout the body’s tissues and is synthesised on demand (Gabrielsson 2016). It was first isolated in 1957 as an anti-inflammatory component in egg yolks and is found in many foods such as Edamame beans. PEA has been studied extensively for its anti-inflammatory, neuroprotective and analgesic properties since the 1970’s.* (Hesselink 2013)

When combined, PEA and luteolin show enhanced anti-inflammatory, anti-oxidant and neuroprotective properties.  This combination has been shown to reduce pro-inflammatory cytokines (TNF-alpha, IL-1 beta, IL-6) and chemokines (MIP-1 alpha, MIP-2) significantly more than PEA or luteolin alone. Additionally, PEA with luteolin was shown to reduce oxidative and nitrosative damage more effectively than PEA or luteolin alone.* (Impellizzeri 2018) . Additionally, it has been found that the combination of PEA and Luteolin in a 10:1 ratio the expression of Akt/mTOR signaling pathways increases and can inhibit autophagy.

With AUTOPHIB™ we have combined this combination with another Autophagy inhibitor; Capsaicin.
Capsaicin inhibits  autophagy by activating the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/ and mammalian target of rapamycin (mTOR) [source] .
Capsaicin induces apoptosis in tumor cells by intracellular calcium increase, reactive oxygen species generation, disruption of mitochondrial membrane transition potential, and activation of transcription factors such as NF-kB and STATS and also reduces resistance to chemotherapeutic treatments.

 

 

Autophagy Pathways
Autophagy initiation is controlled by the ULK kinase complex and the PI13-kinase complex containing Beclin-1, which integrate stress signals from the mTOR complex 1 (mTORC1).

When mTORC1 activity is inhibited such as by AMPK activators Metformin, Berberine, Green Tea and Curcumin, the ULK (serine/threonine-protein kinase) and the Beclin-1 complex translocate to the initiation site  ATG13 (autophagy-related protein) which triggers the self-eating autophagic process. This machinery is also co-opted by various herpes viruses such as Kaposi sarcoma.

In 2016 Yoshinori Ohsumi was awarded the nobel peace prize for identifying gene versions involved in uncontrolled autophagy ( which are mutated in many breast and ovarian tumors) and loss of two others from the brains of mice causes neurodegeneration. In fact, there are now a variety of human neurological diseases where autophagy has been implicated, including Alzheimer’s and Parkinson’s.

 

Human ovarian cancer cells are highly sensitive to challenge with autophagy-targeting agents. Tumor cells with impacted autophagy are marked by accumulation of the yellow gene marker, which disappears as the cells die.

 

The Viral Association with Autophagy

Autophagy may suppress carcinogenesis owing to its key role in the first line of defense against viral and bacterial infection (Deretic et al2013). Indeed, several potentially carcinogenic pathogens potently activate autophagy upon infection. These pathogens include hepatitis B virus (which promotes hepatocellular carcinoma), human herpesvirus 8 (which causes Kaposi’s sarcoma and contributes to the pathogenesis of primary effusion lymphoma and multicentric Castleman’s disease), human papillomavirus type 16 and 18 (HPV‐16 and HPV‐18, which cause cervical carcinoma), Epstein–Barr virus and Helicobacter pylori (both of which are associated with gastric carcinoma), Streptococcus bovis (which causes colorectal carcinoma), Salmonella enterica (which is associated with an increased incidence of Crohn’s disease, hence sustaining colorectal carcinogenesis, and gallbladder carcinoma), as well as Chlamydia pneumoniae (an etiological determinant in some forms of lung cancer) (Nakagawa et al2004; Travassos et al2010; Yasir et al2011; Conway et al2013; Griffin et al2013; Zhang et al2014).

AUTOPHIB™ may be used as an adjuvant to standard care, and as part of a metabolic fuel-blocking approach along with FASNHIB™, GLUTAHIB™  to inhibit metabolic fuel supply and later with MEBENGRAV™ to activate caspases  similar to the press-pulse strategy made famous by Dr Thomas Seyfried and NICLOSTEM™ to help eradicate stem cells.

[To better understand these concepts,  See our MFI Strategy here – Werone Private Herbal Health Trust Members only]

These 3 main metabolic fuel pathways exploited by Tumors are the targets for using Re-purposed drugs such as Metformin, Doxycyline, Dipyridamole,  Niclosamide, Aspirin and a statin to inhibit these pathways which drive the TCA cycle within each Tumor cell with the aim of to weakening it over time. MBZ also interferes with VEGFR kinase by competing with ATP which is the energy used within the TCA Cycle of every cell.

 

 

Biohackit Neutraceuticals Range Buy FASNHIB Buy GLUTAHIB Buy Metastahib Buy Myelomhib Buy VBLOCK Buy NICLOSTEM Buy MEBENGRAV Buy AUTOPHIB Buy BCHIB Buy Mebencur Buy Fenbencide Cream Image Map

Ingredients:

AUTOPHIB™ Ingredients per 2x Vegan Capsules
Palmitoylethanolamide (PEA) (†) 640mg *
Luteolin (from Clerodendron; Pagoda flower)(†) 64mg *
Capsaicin (from capsicum peppers) (↑mTOR)(†) 100mg *
Other ingredients: HPMC Hypromellose (vegetable capsule), zero fillers, (†) Lab-Tested, (§) * Daily value not established

Suggested Usage

Take 2 x caps with water after food in the morning, 2 x caps noon and 2 x caps after food at night or as directed by a health professional. May be suitable as an adjuvant.  AUTOPHIB™ may best be supported with  FASNHIB™ for Fatty Acid inhibition  & GLUTAHIB™ metabolic fuel supply inhibiting formulas,  CURCUBOS™,  CURCUMEL™,  EGAMMA™, OMEGA DHA™, and a ZERO Sugar/Fat Diet with regular cruciferous vegetables (SULFORAPHANE).  The 120 or 180 capsule versions may be more suitable for this. For synthetic chemotherapeutic versions consider: METFORMIN, LD/ASPIRIN and/or STATIN, & DIPYRIDAMOLE & MILDRONATE .

Clinical Studies

Palmitoylethanolamide with Luteolin Decreases Autophagy
https://www.researchgate.net/publication/279807072_The_Association_of_Palmitoylethanolamide_with_Luteolin_Decreases_Autophagy_in_Spinal_Cord_Injury

Capsaicin Inhibits Chemotherapeutic/5-FU-induced Autophagy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416771/

 

Quality Assurance Declaration

Lab-Tested
Werone.co endeavors to use the most potent source materials within our formulas. Our herbal extracts are sourced and tested by the only Government-certified large scale producer of crude herb (powder-free) TCM concentrates in Asia who manufacture to GMP / ISO 9001/2000 pharmaceutical grade and also operate an ISO17025/TAF-certified laboratory where they subject all plant extracts to strict quality inspections free from heavy metals, pesticides or microbes before release to the clinics all over the world. The formulas and tinctures are assembled without fillers in small batches by a BHMA member herbal dispensary.

 

Nutraceutical Disclaimer

These statements have not been evaluated by the Food and Drug Administration or MHRA and the items are not intended to diagnose, treat, cure, or prevent any disease nor are they associated, endorsed, affiliated or sponsored by Anthony William, Medical Medium® Joe Tippens, Jane McLelland or Jim Gordon.

 

 

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22 reviews for AUTOPHIB™ – Autophagy Blocking, Pain Relieving Formula

4.8
Based on 22 reviews
5 star
81%
4 star
18%
3 star
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1 star
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  1. Robin (verified owner)

    Verified reviewVerified review - view originalExternal link | usUnited States

    Another great combo product that targets the necessary metabolic pathways needed to block uncontrolled cell growth.

  2. Laura R. (verified owner)

    Verified reviewVerified review - view originalExternal link | usCalifornia, United States

    All the products from Werone are top notch

  3. Tina Romero (verified owner)

    Verified reviewVerified review - view originalExternal link | frHerault, France

    I really hope this product is as effective as it is well researched and presented. I love the bottle. Received my order very fast. I am looking forward to adding more products into my protocol.

  4. Anonymous (verified owner)

    Verified reviewVerified review - view originalExternal link | gbEngland, United Kingdom

    I enjoy the combination in one pill instead of many separate ones and tolerate it very well

  5. Isabel P. (verified owner)

    Verified reviewVerified review - view originalExternal link | frFrance

    Great supplement

  6. James H. (verified owner)

    Verified reviewVerified review - view originalExternal link

    Nice concentration of ingredients

  7. Anonymous (verified owner)

    Verified reviewVerified review - view originalExternal link | usUnited States

    I am waiting for my next order but I feel the supplements are high quality and provide innovative combinations not found in other places.

  8. Irene (verified owner)

    Verified reviewVerified review - view originalExternal link | dkDenmark

    Good product – Will buy again.

  9. Elaine Thompson (verified owner)

    Verified reviewVerified review - view originalExternal link | gbEngland, United Kingdom

    Excellent product, excellent service.

  10. Vaida B. (verified owner)

    Verified reviewVerified review - view originalExternal link | ltLithuania

    Good quality, quick delivery. I am using this item to help my body to fight c****!

  11. Alison (verified owner)

    Verified reviewVerified review - view originalExternal link | usPennsylvania, United States

    I like the combination product the help block pathways

  12. Peter (verified owner)

    Verified reviewVerified review - view originalExternal link | nlNorth Brabant, Netherlands

    Autophib will help my body to reduce the number of cancer cells

  13. Vanesa Abad (verified owner)

    Verified reviewVerified review - view originalExternal link | esValencia, Spain

    complete product

  14. Ingrid (verified owner)

    Verified reviewVerified review - view originalExternal link

    Although I cannot yet say if it did help me heal from cancer together with many other supplements and natural therapies, I have the feeling it is quite strong and targets specific processes.

  15. Anonymous (verified owner)

    Verified reviewVerified review - view originalExternal link | gbEngland, United Kingdom

    Great ingredients!

  16. Ingrid (verified owner)

    Verified reviewVerified review - view originalExternal link

    seems promising ….

  17. Christina W. (verified owner)

    Verified reviewVerified review - view originalExternal link | usTexas, United States

    Love everything combines in this product!

  18. JULIE GODLEY (verified owner)

    Verified reviewVerified review - view originalExternal link | gbEngland, United Kingdom

    Good product

  19. Vytautas (verified owner)

    Verified reviewVerified review - view originalExternal link | ltVilnius, Lithuania

    Excellent natural product and great customer support.Sincere thanks

  20. Christina W. (verified owner)

    Verified reviewVerified review - view originalExternal link | usTexas, United States

    Love this product. Will be buying more.

  21. JULIE G. (verified owner)

    Verified reviewVerified review - view originalExternal link | gbEngland, United Kingdom

    Good product

  22. Anonymous (verified owner)

    Verified reviewVerified review - view originalExternal link

    Fast delivery

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