Antrodiac – Anti-Metastatic, Anti-inflammatory

(1 customer review)

£ 19.50£ 48.50 

Earn 195 - 485 points upon purchasing this product.

Use 1950 - 4850 points to purchase this product!


This native Taiwanese mushroom Antrodia camphorata (aka Antrodia cinnamomea)  is starting to attract increasing interest because of the exceptionally high concentration of its triterpenoid compounds and their structural diversity. Other important bioactive compounds include polysaccharides, maleic/succinic acid derivatives, benzenoids and benzoquinone derivatives.

Antrodia camphorata is a well-known mushroom that has been used as an herbal medicine for centuries in Taiwan. This mushroom has been used in the treatment of various diseases; e.g. diarrhea, abdominal pain and hypertension

Taiwanese name – Niu Chang Chih

Antrodia camphorata mycelium containing 6% triterpenes with: Antrodin C >12.0mg/g, Antrodin B >1.0mg/g, Adenosine >1.0mg/g and is suitable for vegetarians and vegans and free from dairy, gluten, maize and soya.

With wild-collected material extremely rare and prohibitively expensive, we use cultivated mycelium as a cost-effective alternative, it having >6% triterpenes. Over 78 compounds consisting of terpenoids, benzenoids, lignans, benzoquinone derivatives, succinic and maleic derivatives, in addition to polysaccharides have been identified.

Generally, polysaccharides and triterpenoids are the major bioactive components in medicinal mushrooms. The polysaccharides extracted from A. camphorata were found to have anti-hepatitis B surface antigen [R] and anti-tumor effects.

Antrodia camphorata extracts from its fruiting bodies, mycelium and cultivation filtrate showed multiple cancer preventive and anti-inflammatory activities. Triterpenes are considered to be potential anti-tumor agents due to activity against growing tumors, they have direct cytotoxicity against tumor cells rather than to normal cells.[R]

In addition, these extracts provide a variety of anti-cancer and anti-inflammatory active secondary metabolites and polysaccharides. Of particular promise, due to their potent cytotoxic activity against a number of cancer cell lines, are the triterpenoids with ketonic functional groups. In fact, these triterpenoids, which have also been found in a small number of other mushrooms, are currently under active investigation as potential therapeutic leads [R]. Because the antioxidant action is also a means of lowering chronic anti-inflammatory action, A. camphorata hold potential in functional food approaches aimed at normalizing metabolic syndrome.



Reported data has showed that A. camphorata may exert its hepatoprotective effects, though different mechanisms such as scavenging free radicals responsible for cell damage, enhancing the enzymes responsible for antioxidant activity, inhibiting the inflammatory mediators and/or induction of the regeneration of the liver cells.  Previously reported data revealed that A. camphorata is a potent free radical scavenger [R]. It is therefore possible that hepatoprotective action of Antrodia camphorata is partially due to its antioxidant activity.




The pathways with which Antrodia camphorata acts upon are very extensive, the most extensive we’ve ever seen from a mushroom, even chemotherapy drugs usually only often act on one to 4 pathways at the most, Antrdoia camphorata  acts upon around 33. It also acts upon the 4 major pathways in cancer cell metastasis, the transcription, proliferation, angiogenesis and migration and without affecting healthy stem cells. The below diagram shows the functions governing the programmed death of a cell known as apoptosis.

You can click here for a larger version of the diagram

Cancer is one of the scenarios where too little apoptosis occurs, resulting in malignant cells that will not die. The mechanism of apoptosis is complex and involves many pathways. Defects can occur at any point along these pathways, leading to malignant transformation of the affected cells, tumour metastasis and resistance to anticancer drugs.

One example is the downregulation of p53, a tumour suppressor gene, which results in reduced apoptosis and enhanced tumour growth and development [R] and inactivation of p53, regardless of the mechanism, has been linked to many human cancers

The execution phase of apoptosis involves the activation of a series of caspases. The upstream caspase for the intrinsic pathway is caspase 9 while that of the extrinsic pathway is caspase 8. The intrinsic and extrinsic pathways converge to caspase 3.  Caspase 3 then cleaves the inhibitor of the caspase-activated deoxyribonuclease, which is responsible for nuclear apoptosis [R].

In one study, downregulation of caspase-9 was found to be a frequent event in patients with stage II colorectal cancer and correlates with poor clinical outcome



Cancer-initiating cells (CIC’s)  or cancer stem cells (CSC’s) are a rare sub-population of cancer cells, which are responsible for tumor growth and cancer recurrence during conventional chemotherapy or radiotherapy [R]. Over the past decade, increasing evidence suggests that the hierarchical model of cancer initiating cells (CIC’s) or cancer stem cells (CSC’s) in that each tumor formation is governed by a rare sub-population of cells with self-renewal capacity . CIC’s have been demonstrated to have capacities of promoting tumor growth, tumor regeneration, metastatic progression, and tumor recurrence [R].


The effects of Antrodia cinnamomea against Liver Cancer

Use of Antrodia cinnamomea resulted in the increase of caspase-3 and caspase-8 proteolytic activities and induced the proteolysis of pro-caspase-8 and procaspase-3. The above results indicated that Antrodia cinnamomea induced HepG2 apoptosis through the activation of caspase-3 and caspase-8 cascades and the regulation of cell cycle progression.

Review of Pharmacological Effects of Antrodia camphorata and Its Bioactive Compounds

Suggested Usage: 3-4 capsules, twice per day, up to 6 for short periods may be needed, there are no toxicity concerns known however, the effect of taking high doses of Antrodia Camphorata tumor lysis could be expected. This can be reduced by good daily hydration(with fresh lemon)  and good liver support with lymphatic exercise, Digestive Enzymes, Amino acids, B vitamins, MSM, R-ALA, Vitamin C and Coffee enemas or Coffee bullets.

Tumor Lysis Syndrome
There are risks involved in using anti tumor compounds because when they start to break down necrotic matter or simply destroy many cancer cells in a short time, the toxins released can be life-threatening if done more quickly than the liver and kidneys can process and expel them. Therefore monitoring of these toxins in the urine should be done by your clinic to ensure that the levels of uric acid, potassium and other proteins does not get too high .

Having at least 40 Black Cherries on hand should a situation arise can be a helpful antidote, taking 30-40 of these can reduce the uric acid in an emergency. There are also drugs which can be used such as anti-gout medication: Allopurinol (Zyloprim).


Quality Assurance Declaration

Lab-Tested endeavors to use the most potent source materials within our formulas. Our herbal extracts are sourced and tested by the only Government-certified large scale producer of crude herb (powder-free) TCM concentrates in Asia who manufacture to GMP / ISO 9001/2000 pharmaceutical grade and also operate an ISO17025/TAF-certified laboratory where they subject all plant extracts to strict quality inspections free from heavy metals, pesticides or microbes before release to the clinics all over the world. The formulas and tinctures are assembled without fillers in small batches by a BHMA member herbal dispensary.


Nutraceutical Disclaimer

These statements have not been evaluated by the Food and Drug Administration or MHRA and the items are not intended to diagnose, treat, cure, or prevent any disease nor are they associated, endorsed, affiliated or sponsored by Anthony William, Medical Medium® Joe Tippens, Jane McLelland or Jim Gordon.



1. Borchers AT, Keen CL, Gershwin ME. Mushrooms, tumors, and immunity: an update. Experimental Biology and Medicine. 2004;229(5):393–406. [PubMed]

2. Borchers AT, Krishnamurthy A, Keen CL, Meyers FJ, Gershwin ME. The immunobiology of mushroomsExperimental biology and medicine. 2008;233(3):259–76. doi: 10.3181/0708-MR-227 [PubMed]
3. Geethangili M, Tzeng Y-M. Review of pharmacological effects of Antrodia camphorata and its bioactive compounds. Evidence-Based Complementary and Alternative Medicine. 2011;2011. [PMC free article] [PubMed]
4. Wang G-J, Tseng H-W, Chou C-J, Tsai T-H, Chen C-T, Lu M-K. The vasorelaxation of Antrodia camphorata mycelia: involvement of endothelial Ca 2+-NO-cGMP pathway. Life sciences. 2003;73(21):2769–83. [PubMed]
5. Hsiao G, Shen M-Y, Lin K-H, Lan M-H, Wu L-Y, Chou D-S, et al. Antioxidative and hepatoprotective effects of Antrodia camphorata extract. Journal of Agricultural and Food Chemistry. 2003;51(11):3302–8.[PubMed]
6. Song T-Y, Yen G-C. Protective effects of fermented filtrate from Antrodia camphorata in submerged culture against CCl4-induced hepatic toxicity in rats. Journal of Agricultural and Food Chemistry. 2003;51(6):1571–7.[PubMed]
7. Hsu Y-L, Kuo Y-C, Kuo P-L, Ng L-T, Kuo Y-H, Lin C-C. Apoptotic effects of extract from Antrodia camphorata fruiting bodies in human hepatocellular carcinoma cell lines. Cancer letters. 2005;221(1):77–89.[PubMed]
8. Yang H-L, Chen C-S, Chang W-H, Lu F-J, Lai Y-C, Chen C-C, et al. Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by Antrodia camphorata. Cancer letters. 2006;231(2):215–27. [PubMed]
9. Peng C-C, Chen K-C, Peng RY, Chyau C-C, Su C-H, Hsieh-Li HM. Antrodia camphorata extract induces replicative senescence in superficial TCC, and inhibits the absolute migration capability in invasive bladder carcinoma cells. Journal of ethnopharmacology. 2007;109(1):93–103. [PubMed]
10. Lee I-H, Huang R-L, Chen C-T, Chen H-C, Hsu W-C, Lu M-K. Antrodia camphorata polysaccharides exhibit anti-hepatitis B virus effects. FEMS Microbiology Letters. 2002;209(1):63–7. [PubMed]
11. Liu J-J, Huang T-S, Hsu M-L, Chen C-C, Lin W-S, Lu F-J, et al. Antitumor effects of the partially purified polysaccharides from Antrodia camphorata and the mechanism of its action. Toxicology and applied pharmacology. 2004;201(2):186–93. [PubMed]
12. Wang X, Yang L, Chen ZG, Shin DM. Application of nanotechnology in cancer therapy and imaging. CA: a cancer journal for clinicians. 2008;58(2):97–110. [PubMed]
13. Kumar MR, Muzzarelli RA, Muzzarelli C, Sashiwa H, Domb A. Chitosan chemistry and pharmaceutical perspectives. Chemical reviews. 2004;104(12):6017–84. [PubMed]
14. Bodnar M, Hartmann JF, Borbely J. Preparation and characterization of chitosan-based nanoparticles.Biomacromolecules. 2005;6(5):2521–7. [PubMed]
15. Janes KA, Fresneau MP, Marazuela A, Fabra A, Alonso MJ. Chitosan nanoparticles as delivery systems for doxorubicin. Journal of Controlled Release. 2001;73(2):255–67. [PubMed]
16. Lozano MV, Torrecilla D, Torres D, Vidal A, Domiínguez F, Alonso MJ. Highly efficient system to deliver taxanes into tumor cells: docetaxel-loaded chitosan oligomer colloidal carriers. Biomacromolecules. 2008;9(8):2186–93. doi: 10.1021/bm800298u [PubMed]
17. Mi F-L, Wu Y-Y, Chiu Y-L, Chen M-C, Sung H-W, Yu S-H, et al. Synthesis of a novel glycoconjugated chitosan and preparation of its derived nanoparticles for targeting HepG2 cells. Biomacromolecules. 2007;8(3):892–8. [PubMed]
18. Zhang H, Oh M, Allen C, Kumacheva E. Monodisperse chitosan nanoparticles for mucosal drug delivery.Biomacromolecules. 2004;5(6):2461–8. [PubMed]
19. Cai X-J, Xu Y-Y. Nanomaterials in controlled drug release. Cytotechnology. 2011;63(4):319–23. doi:10.1007/s10616-011-9366-5 [PMC free article] [PubMed]
20. Lin L-N, Liu Q, Song L, Liu F-F, Sha J-X. Recent advances in nanotechnology based drug delivery to the brain. Cytotechnology. 2010;62(5):377–80. doi: 10.1007/s10616-010-9295-8 [PMC free article] [PubMed]
21. Barbe C, Bartlett J, Kong L, Finnie K, Lin HQ, Larkin M, et al. Silica Particles: A Novel Drug-Delivery System. Advanced materials. 2004;16(21):1959–66.
22. Slowing II, Trewyn BG, Giri S, Lin VY. Mesoporous silica nanoparticles for drug delivery and biosensing applications. Advanced Functional Materials. 2007;17(8):1225–36.
23. Coradin T, Lopez PJ. Biogenic silica patterning: simple chemistry or subtle biology? ChemBioChem. 2003;4(4):251–9. [PubMed]
24. Chang J-S, Kong Z-L, Hwang D-F, Chang KLB. Chitosan-catalyzed aggregation during the biomimetic synthesis of silica nanoparticles. Chemistry of materials. 2006;18(3):702–7.
25. Chang J-S, Chang KLB, Hwang D-F, Kong Z-L. In vitro cytotoxicitiy of silica nanoparticles at high concentrations strongly depends on the metabolic activity type of the cell line. Environmental Science & Technology. 2007;41(6):2064–8. [PubMed]
26. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. Journal of immunological methods. 1983;65(1):55–63. [PubMed]
27. Chou C-T, Lin W-F, Kong Z-L, Chen S-Y, Hwang D-F. Taurine prevented cell cycle arrest and restored neurotrophic gene expression in arsenite-treated SH-SY5Y cells. Amino acids. 2013;45(4):811–9. doi:10.1007/s00726-013-1524-y [PubMed]
28. Kong Z-L, Chang J-S, Chang KLB. Antiproliferative effect of Antrodia camphorata polysaccharides encapsulated in chitosan–silica nanoparticles strongly depends on the metabolic activity type of the cell line. Journal of nanoparticle research. 2013;15(9):1–13.
29. Hardman R. A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors. Environmental health perspectives. 2006;114(2):165–72. [PMC free article] [PubMed]
30. Shim W, Paik MJ, Nguyen D-T, Lee J-K, Lee Y, Kim J-H, et al. Analysis of Changes in Gene Expression and Metabolic Profiles Induced by Silica-Coated Magnetic Nanoparticles. ACS nano. 2012;6(9):7665–80.[PubMed]
31. Foldbjerg R, Olesen P, Hougaard M, Dang DA, Hoffmann HJ, Autrup H. PVP-coated silver nanoparticles and silver ions induce reactive oxygen species, apoptosis and necrosis in THP-1 monocytes. Toxicology Letters. 2009;190(2):156–62. doi: 10.1016/j.toxlet.2009.07.009 [PubMed]
32. Latchoumycandane C, Marathe GK, Zhang R, McIntyre TM. Oxidatively truncated phospholipids are required agents of tumor necrosis factor α (TNFα)-induced apoptosis. Journal of Biological Chemistry. 2012;287(21):17693–705. doi: 10.1074/jbc.M111.300012 [PMC free article] [PubMed]
33. Maes M, Fišar Z, Medina M, Scapagnini G, Nowak G, Berk M. New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates—Nrf2 activators and GSK-3 inhibitors.Inflammopharmacology. 2012;20(3):127–50. doi: 10.1007/s10787-011-0111-7 [PubMed]
34. Silva ACRA, de Almeida BFM, Soeiro CS, Ferreira WL, de Lima VMF, Ciarlini PC. Oxidative stress, superoxide production, and apoptosis of neutrophils in dogs with chronic kidney disease. Canadian Journal of Veterinary Research. 2013;77(2):136–41. [PMC free article] [PubMed]
35. Huang G-J, Deng J-S, Huang S-S, Shao Y-Y, Chen C-C, Kuo Y-H. Protective effect of antrosterol from Antrodia camphorata submerged whole broth against carbon tetrachloride-induced acute liver injury in mice. Food Chemistry. 2012;132(2):709–16.
36. Mou H, Zheng Y, Zhao P, Bao H, Fang W, Xu N. Celastrol induces apoptosis in non-small-cell lung cancer A549 cells through activation of mitochondria-and Fas/FasL-mediated pathways. Toxicology in Vitro. 2011;25(5):1027–32. doi: 10.1016/j.tiv.2011.03.023 [PubMed]
37. Nagata S, Golstein P. The Fas death factor. Science. 1995;267(5203):1449–56. [PubMed]
38. Hseu Y-C, Yang H-L, Lai Y-C, Lin J-G, Chen G-W, Chang Y-H. Induction of apoptosis by Antrodia camphorata in human premyelocytic leukemia HL-60 cells. Nutrition and Cancer. 2004;48(2):189–97. [PubMed]
39. Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, et al. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell. 1997;91(4):479–89. [PubMed]
40. Mignotte B, Vayssiere JL. Mitochondria and apoptosis. European Journal of Biochemistry. 1998;252(1):1–15. [PubMed]
41. Tepper CG, Seldin MF, Mudryj M. Fas-mediated apoptosis of proliferating, transiently growth-arrested, and senescent normal human fibroblasts. Experimental cell research. 2000;260(1):9–19. [PubMed]
42. Cohen G. Caspases: the executioners of apoptosis. Biochem j. 1997;326:1–16. [PMC free article] [PubMed]

Additional information

Weight N/A

, ,

1 review for Antrodiac – Anti-Metastatic, Anti-inflammatory

5 star
4 star
3 star
2 star
1 star
  1. Anonymous (verified owner)

    Verified reviewVerified review - view originalExternal link

    This product is hard to find elsewhere, great service and selection.

Only logged in customers who have purchased this product may leave a review.