MEL60™ / MEL90™ / MEL200™ is an exciting High Dose Melatonin which may help with halting cellular degradation. For the low dose ‘sleep only’ version see: MelMagic™
Melatonin is a natural neurohormone produced in humans by the pineal gland. A favourite of travellers, it governs the body’s circadian rhythms, helping the body ease into restful sleep and is also a potent antioxidant. However, in other contexts and higher dosages it has been found to have strong anti-estrogenic effects (after 4 months of HD usage) and even stronger actions to ER Stress which if sustained can initiate programmed cell death (PCD) to tumor cells via UPR, Melatonin at high dosages has also been found to enhances the cytotoxicity of targeted anti-tumor drugs.
Andersen LP et al. University of Copenhagen)
MEL™ HD contains a beneficial filler – Pectin
Many supplements these days contain fillers which don’t actually help support the active ingredient much, with MEL60™ / MEL90™ / MEL200™ HD we decided to make a positive change by including one or the most well-known beneficial ingredients as a companion to melatonin, that is apple pectin. Pectin is one of these natural compounds, a complex polysaccharide found in apples and has anti-tumor properties.
In a 2016 Iranian study on mice, The results of in vitro studies showed that concentration of 0.1% of pectic acid could induce apoptosis, inhibit cell growth (p < 0.001) and reduce cell attachment, fragmented chromatin, and membrane blebbing as well as blocking the sub-G1 phase (p < 0.001). In addition, in vivo studies showed that pectic acid could inhibit the progression of tumors through over-expression of P53 and increasing the number of apoptotic cells. Their demonstrated that pectic acid, a natural component of apple, can prevent metastasis in both tumor cell lines and primary tumors. This potential effect is mainly due to its ability to induce apoptosis.
To find out more about the amazing benefits of Melatonin, please watch the below short documentaries.
Some people report that taking melatonin at lower dosages can cause drowsiness the next day, however, high dosage Melatonin (60 – 300mg) tends not to cause such effects.
Melatonin & Cellular Health
High Dosage Melatonin, Even In the Day?
Dr. Frank Shallenberger, the president of the American Ozone Therapy Association, will demonstrate the crucial role of oxidative therapies in the maintenance and enhancement of mitochondrial energy production, an absolute necessity for better health and optimal aging.
Melatonin May Be A Tumor’s Worst Nightmare
The hormone melatonin produces a number of health benefits in terms of your immune system. It’s a powerful antioxidant and free radical scavenger that helps combat inflammation. In fact, melatonin is so integral to your immune system that a lack of it causes your thymus gland, a key component of your immune system, to atrophy. Melatonin may even have a role in slowing the aging of your brain.
In addition to helping you fall asleep and bestowing a feeling of overall comfort and well being, melatonin has proven to have an impressive array of anti-tumor benefits. Melatonin inhibits the proliferation of a wide range of tumor cell types, as well as triggering tumor cell apoptosis (self destruction). The hormone also interferes with the new blood supply tumors require for their rapid growth (angiogenesis). Melatonin can boost efficacy and decrease the toxicity of tumor chemotherapy.
Omega 6 Fatty Acids and Tumor Progression
Cancer cell proliferation and tumor growth also rely on the cellular uptake of linoleic acid (LA), an essential omega-6 fatty acid (PUFA) that is the most prevalent FA in the western diet and found in Linoleic acid is the predominant n-6 polyunsaturated fatty acid (PUFA) in the Western diet and we can obtain it from vegetable oils such as sunflower, safflower, soybean, corn, and canola oils as well as walnuts and seeds. A table spoon of soybean or corn oil contains about 7-8 g of linoleic acid, and 7 shelled walnuts provide about 11 g of linoleic acid. In many tumors, cancer cells take-up LA via a cAMP-dependent transport mechanism and metabolise it to the mitogen 13-hydroxyoctadecadienoic acid (13-HODE) by the enzyme 15-lipoxygenase-1 , the activity of which is up-regulated by activation of epidermal growth factor (EGF) and insulin-like growth factor-1 (IGF-1) receptors . [source]
Blue Light at Night May be Killing Us
Peer-reviewed and published research has shown Melatonin offers particularly strong protection against reproductive tumors. Cells throughout your body — even tumor cells — have melatonin receptors. So when melatonin makes its nightly rounds, cell division slows. When this hormone latches onto a breast tumor cell, it has been found to counteract estrogen’s tendency to stimulate cell growth.
In fact, melatonin has a calming effect on several reproductive hormones, which may explain why it seems to protect against sex hormone-driven tumors, including ovarian, endometrial, breast, prostate and testicular tumor . GreenMedInfo lists twenty studies demonstrating exactly how melatonin exerts its protective effects against breast tumor .
But melatonin’s anti-tumor effects don’t stop there. While causing tumor cells to self-destruct, melatonin also boosts your production of immune stimulating substances such as interleukin-2, which helps identify and attack the mutated cells that lead to tumor . Through these dual actions, melatonin delivers a one-two punch!
Melatonin in the nanomolar range activates the intrinsic and/or the extrinsic apoptotic pathway in tumor cells, Melatonin is a CDK2 and CDK4 (cyclin-dependent kinases) inhibitor and for breast, gastro-intestinal, liver, ovarian, prostate, bone-tumor , melanoma & kidney tumors through an increase in the p53/MDM2p ratio and downregulation of Sirt1. This finding is of great relevance since there is intense research ongoing to identify nontoxic feasible inhibitors of MDM2 and Sirt1. [source]
Melatonin is derived almost entirely from the pineal gland, as shown by the fact that undetectable melatonin levels are found . After its release, melatonin is bound to albumin and reaches tissues within a very short period . The melatonin molecule possesses lipophilic and hydrophilic properties that permit its transfer into many tissues and fluids. Depending upon the site of production and target organ, melatonin can act as a hormone, immuno-modulator or as a biological modifier .
Melatonin has been identified as a natural chronobiotic substance with immune-enhancing properties as well as the ability to reduce oxidative stress. Thus, melatonin could potentially be used as a therapeutic substance for the prevention or arrest of neoplastic growth . The concentrations of melatonin in ovarian follicles tend to increase with follicular growth . It is possible that melatonin acts as an antioxidant . Furthermore, the anti-apoptotic effect of melatonin has been observed in a variety of cell types . And there are indications that melatonin can help prevent and treat oxidative damage as well as suppress specific inflammatory factors .
Tumor Therapy Adjuvant and Immune Regulator
Emerging research suggests that melatonin has anti-tumor properties—that is, it has the ability to prevent tumors from occurring, or to induce the tumor cell death if it does occur. This has been attributed to melatonin’s antioxidant, anti-inflammatory, anti-proliferative, and hormone-modulating properties.
It has been successfully used in individuals with advanced stage tumors undergoing conventional antitumor therapy, by either slowing disease progression and/or decreasing treatment side effects. 53-60 In a review of 8 randomised, controlled clinical trials evaluating the benefits of melatonin as an adjuvant therapy for tumor patients with solid tumors undergoing chemotherapy or radiation therapy. Researchers found that concurrent use of 20 mg of melatonin once daily versus conventional treatment alone, improved the rate of complete or partial remission by nearly 50%, increased the one-year survival rate by 45%, and decreased the devastating side effects of conventional therapy such as low platelet count, neuropathy, and fatigue by 89%, 83%, and 65% respectively. 59 What’s more, these effects were consistent across different types of tumor and there were no adverse events reported.
Melatonin’s anti-tumor properties can also be attributed to its effect on your immune system. Laboratory studies revealed that melatonin can activate T-helper cells, which triggers other immune cells in order to help kill off foreign invaders or pathogens. Additionally, melatonin stimulates natural killer cell, monocyte, and macrophage synthesis, and has been found to facilitate healthy cell-to-cell communication, which enhances the body’s appropriate immune system response to foreign invaders.
Based on available evidence, leading experts suggest that patients with tumors and particularly metastatic solid tumors, might benefit from melatonin use, potentially leading to improved therapeutic outcomes. Certainly, more research is warranted.
Melatonin not only inhibits breast tumor cell growth, but also is capable of inhibiting angiogenesis, tumor cell invasion and telomerase activity. Interestingly this hormone is able to induce apoptosis through the suppression or induction of a wide range of signaling pathways. Moreover, it seems that the concomitant administration of melatonin with other conventional chemotherapy agents had beneficial effects for patients with breast tumor , by alleviating unfavorable effects of those agents and enhancing their efficacy.
The broad inhibitory effects of melatonin in breast tumors make it a promising agent and may add it to the list of potential drugs in treatment of this tumor. https://www.ncbi.nlm.nih.gov/pubmed/27017208
New evidence is showing that when Melatonin & Curcumin is taken throughout the day and at night at high dosage many mutagenic processes are inhibited or even halted.
Suggested Use: 1 x 60mg capsule every 4 hours during the day and either 2 x 90mg caps or 1 x 200mg cap/s before bedtime, (however, build slowly with 1/4 to 1/2 capsule for a few days if you are new to Melatonin supplements), please check with your health practitioner. Do not exceed the suggested use unless recommended by your physician. If using for targeting rogues cells, the target to build up to is 20mg to 300mg according to the studies, but do not try this initially, you’ll need to build up to it unless you are already accustomed to high levels.
MEL60™, MEL90™, MEL200™ may best be combined with 20,000 IU Vitamin D3/K2, Citric acid and warm water hydration aswell as off-label drug and nutritional strategies described in our MFI Strategy here – Werone Private Herbal Health Trust Members only]. Remove all sources of Omega 6 PUFA veg oils and nuts from the diet. [Source]
For adult use only. Not for use by children, teenagers, or women who are pregnant, may become pregnant or breastfeeding. Do not drive, operate machinery or consume alcohol or other sedatives while taking this supplement. If you are under medical supervision, or have an autoimmune disease, diabetes, a depressive disorder, a thyroid condition, epilepsy, leukemia, or a lymphoproliferative disorder, or are taking MAO inhibitor drugs or corticosteroids such as hydrocortisone or prednisone, consult your physician before taking this supplement.
Contraindications (Do not take melatonin in the following circumstances):
- * With Autoimmune conditions such as arthritis and lupus
- * If Taking an immunosuppressant
- * If Pregnant
- * Caution if you are taking a sedative, hypnotic (sleeping medications), blood pressure medications, seizure medications, diabetes medications
Despite melatonin’s antioxidant properties, it has demonstrated a tendency to stimulate inflammation in people with certain autoimmune disorders. A study published in the October 2007 issue of the “British Journal of Clinical Pharmacology” demonstrated that rheumatoid arthritis slightly worsened in study subjects who took melatonin [source] . Other autoimmune conditions which seem to benefit (slightly) are Crohns, IBD and Diabetes (see diagram below).
However, most autoimmune conditions are a result of leaky gut caused by grains, stress, heavy metals, bacteria and other toxins. Detoxing these and healing the gut is a more effective strategy. See our Heal Ur Gut™ range.
contains no yeast, dairy, egg, gluten, corn, soy or wheat. Contains no sugar, starch, salt, preservatives, or artificial color, flavor or fragrance.
Quality Assurance Declaration
Werone.co endeavors to use the most potent source materials within our formulas. Our herbal extracts are sourced and tested by the only Government-certified large scale producer of crude herb (powder-free) TCM concentrates in Asia who manufacture to GMP / ISO 9001/2000 pharmaceutical grade and also operate an ISO17025/TAF-certified laboratory where they subject all plant extracts to strict quality inspections free from heavy metals, pesticides or microbes before release to the clinics all over the world. The formulas and tinctures are assembled without fillers in small batches by a BHMA member herbal dispensary.
Nutraceutical DisclaimerThese statements have not been evaluated by the Food and Drug Administration or MHRA and the items are not intended to diagnose, treat, cure, or prevent any disease nor are they associated, endorsed, affiliated or sponsored by Anthony William, Medical Medium® Joe Tippens, Jane McLelland or Jim Gordon.
Melatonin and tumeric ameliorate aging-induced changes: implication of immunoglobulins, cytokines, DJ-1/NRF2 and apoptosis regulation
Melatonin and tumeric ameliorate aging-induced changes: implication of immunoglobulins, cytokines, DJ-1/NRF2 and apoptosis regulation
Melatonin potentiates the antitumor effect of curcumin by inhibiting IKKβ/NF-κB/COX-2 signaling pathway
Apple pectin: A natural source for cancer suppression inbreast cancer cells in vitro and express p53 in mouse bearing cancer tumors, in vivo
Melatonin reduces immunosenescence as characterized by reduced levels of peripheral naïve T cells derived from thymus and the loss of immature B lineage cells in the bone marrow.
Melatonin is a CDK2 and CDK4 (cyclin-dependent kinases) inhibitor and for breast, gastro-intestinal, liver, ovarian, prostate, bone-cancer, melanoma & kidney cancer through an increase in the p53/MDM2p ratio and downregulation of Sirt1.
Melatonin Suppresses the Growth of Ovarian Cancer Cell Lines (OVCAR-429 and PA-1) and Potentiates the Effect of G1 Arrest by Targeting CDKs
Focused Research Topics Melatonin & Breast Cancer
9. Hardeland R., Cardinali D.P., Brown G.M., Pandi-Perumal S.R. Melatonin and brain inflammaging. Prog. Neurobiol. 2015;127–128:46–63.