Metabolic Fuel Inhibition Strategy - MFIS


The aim of MFIS is to block all fuels and target the key dis-regulated genes to lower the energy available so that mutant cells commit suicide & homeostasis is established.

Resources: Protocols for various tumor types may be found within our BiohackIT™ phone Web App :  Sign-up Here

Cancer metabolic reprogramming has been recognised as one of the ten cancer hallmarks by Drs. Hanahan and Weinberg in their seminal review paper published in 2011.

Metabolic Fuel Inhibition is a Strategy based upon this information.

Hallmarks of Cancer: The Next Generation – 2011
https://www.cell.com/cell/fulltext/S0092-8674(11)00127-9

Cancer Metabolic Reprogramming – 2014
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969803/

Autophagy and Cancer Metabolism – 2014
https://www.sciencedirect.com/science/article/pii/B9780124166189000029

THE EMERGING HALLMARKS OF CANCER METABOLISM – 2015
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4715268/

Cancer metabolic reprogramming: importance, main features, and potentials for precise targeted anti-cancer therapies – 2014
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969803

A holistic view of cancer bioenergetics: mitochondrial function and respiration play fundamental roles in the development and progression of diverse tumors – 2016
https://www.researchgate.net/publication/292072716_A_holistic_view_of_cancer_bioenergetics_mitochondrial_function_and_respiration_play_fundamental_roles_in_the_development_and_progression_of_diverse_tumors