The Magic Protocol Just Got SmarterC ancer cells are very unusual cells, they have a secret weapon, a force field which makes the cells invisible to the immune system which is so strong that it evades penetration by most if not all of the pharmaceuticals drugs used against them, except for multiple rounds of industrial strength chemotherapy which unfortunately ravages the healthy cells too and more often results in the loss of the patient. However, Cancer cells do have a weak link and most of us have been using the wrong tools to exploit this weakness. Let me explain..
Although efficacious in the lab, it is well known that immunotherapeutic modalities lose their potency when applied in the body, furthermore, malignant cell exposure to blood platelets attenuates the anticancer activity of natural killer (NK) cells. Senior Researcher at Harvard Medical School in Boston; Dr B Lipinski posited in his 2014 study that upon contact with redox iron, the fibrinogen which covers and protects cancer cells from the immune system is converted to a hydrophobic fibrin-like polymer that coats tumor cells and provides even greater protection from immune-mediated destruction.
In order for a wound to heal, the fibrin clot must be eliminated by proteolytic enzymes. In certain instances, however, fibrin is ineffectively degraded or even not degraded. For example, in pregnancy, the placenta contains a layer of fibrin which presents as ‘self’ to the immune system.
Cancer’s Weakest Link – Main Protocol Ingredients
Normally fibrin is created by thrombin present in the blood to form clots however in the case of extra-resistent cancer cells there appears to be another important hemostatic factor; plasma fibrinogen that, in the presence of free iron, form scrambled intermolecular linkages resulting in the formation of fibrin-like fibrils (parafibrin). This insoluble polymer forms a protective barrier around tumor cells by means of the hydrophobic interaction, those formed in the presence of iron ions exhibit dramatically different physico-chemical properties.
The most important feature of parafibrin is its hydrophobicity and total resistance to proteolytic degradation. This unusual phenomenon is due to the fact that the hydrophobic forces holding together the polypeptide chains are purely physical and do not involve peptide bonds. Consequently, once attached to the surfaces of various cells, parafibrin induces a permanent state of inflammation by eliciting the release of cytokines and proteases from macrophages that impairs their normal functions.
How do Tumor Cells Escape Detection?
Similar situations have been observed in many solid tumors. Lipinski presented the hypothesis according to which tumor cells can escape detection and attack by the immune system in most cancer patients. The tumor dons a ‘coat’ of the host’s own protein on its cell surface. The coat is composed of fibrin and of a polymeric form of human serum albumin (HSA) which, by contrast to pure fibrin or parafibrin and is resistant to proteolytic degradation.
Such a coated tumor appears as ‘self’ to the immune system, and thus is not detected as a tumor by the immune system (i.e. natural killer cells). When tumors are prepared for in vitro assays against drugs, they are routinely treated with proteolytic enzymes (e.g. pepsin, or chymotrypsin, etc, which are in FibriZyme) which dissolve the protein coat, exposing the tumor cell surface to the drug. Thus, when the same drugs are used in the body the existence of a coat on the tumor surface may explain why some drugs have little or no effect in vivo, while the same drugs are active in the lab dish.
Accumulating evidence suggests that a correlation exists between increased blood concentration of unbound iron and the incidence of cancer in humans.13,14 Furthermore, iron level reduction may prevent cancer morbidity and mortality.15–17 It should be noted that it is only trivalent iron (Fe3+) and not divalent (Fe2+) which participate in the generation of hydroxyl radicals and subsequent formation of insoluble parafibrin from soluble plasma fibrinogen.8
How do we Dissolve the parafibrin?
Diets with high content of antioxidant polyphenols are associated with low prevalence of cardiovascular diseases and cancer. Inflammatory angiogenesis is a key pathogenic process both in cancer and atherosclerosis, and is tightly regulated by the proinflammatory enzyme cyclooxygenase (COX)-2 and the matrix degrading enzymes matrix metalloproteinases (MMPs)
In view of the known cancer protective effect of Mediterranean diet, it is quite possible that certain polyphenolic substances present in this diet, such as EGCG, ferulic acid, and curcumin may exert their preventive and/or therapeutic effects by helping remove the protective barrier from the tumor membranes. The proposed mechanism of the action of polyphenols is based on their amphiphilic character that allows parafibrin to be displaced in a zipper-like manner
Dissolving the Parafibrin Protection using Polyphenols
It is proposed in this paper that the barrier formed around tumor cells composed of proteolytically resistant parafibrin can be removed by a non-enzymatic mechanism based on the interaction of hydrophobic and hydrophilic groups (Figure 1). Numerous natural substances, particularly those of amphiphilic nature such as polyphenols, when ingested with diet in sufficient quantities can prevent and/or reverse cancer formation and metastases (26–33). These findings may explain beneficial effects of the Mediterranean diet known to be associated with lower incidence of cancer and other degenerative diseases (34).
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Dr Nick Gonzalez used high dosage of proteolytic enzymes to weaken tumor cells making them vulnerable to a newly invigorated immune system.
Enzymes are extremely vital to human well-being. They play a critical role in digestion and nutrient assimilation, in immune response, cognitive acceleration, and cellular detoxification among other things. Enzyme therapy has shown incredible promise in natural protocols for cancer since the early 1900s (1).
Enzymes are some of the most important structures in the body. They are long-chain proteins that take on specific shapes and act like a key to unique locks throughout the body. Their job is to carry out very specific functions throughout the body. They assist the body in healing and regenerative functions as well as immune system modulation that plays a very important role in disease development.
Systemic enzymes can be used to treat cancer by boosting natural immune system defenses such as cytokines, macrophages and natural killer cells which target abnormal growing cells and inhibit further synthesis (9). Effective systemic enzyme supplements you may consider are FibriZyme Proteolytic Enzymes and can be found here.
Cancer cells are covered in fibrin which is a thick outer coating designed to prevent the bodies immune system from identifying and destroying the cancer cell. This fibrin defense keeps chemotherapy out of the cells unless industrial strength doses are used. This high dose chemotherapy is also extremely toxic to the body.
Systemic enzymes have been shown to break down the outer fibrin wall of the cancer cell making it easier for chemotherapy to penetrate and destroy the cancer cells (4). This allows lower dosages of chemotherapy to be used. Enzyme therapy has also shown to reduce the side effects of chemotherapy and reducing the debilitating muscle wasting that chemo therapy produces (5).
Patients undergoing chemotherapy often have many side effects such as nausea, vomiting, diarrhea, pain and fatigue. Research has shown that enzyme therapy reduces these symptoms by reducing the cytotoxic effects of chemotherapy to the rest of the body (5).
Additionally, we have revived an 1800 year old herbal formula known as Huang Qin Tang (HQT) as a tincture which repairs the Gut and can treat the severe gastrointestinal symptoms of chemo, such as diarrhea, nausea and vomiting, fever, headache, IBS symptoms, and Inflammatory Bowel Disease.
Digestive problems are a modern day epidemic in Westernized cultures. Major disorders such as irritable bowel syndrome, ulcerative colitis, celiac disease, diarrhea and constipation are all too frequent.
The modern day diet and lifestyle is loaded with toxins and deficient in high quality live foods full of enzymes and probiotics. Improve your digestive health naturally with an anti-inflammatory diet and lifestyle.
Anti Inflammatory Diet
Anti-inflammatory foods reduce inflammatory activity in the body and help heal the gut. Great anti-inflammatory foods include coconut products, grass-fed ghee, avocados, olive oil, berries & phytonutrient rich vegetables.
Healthy meat sources such as grass-fed beef, wild game, wild salmon, organic poultry and organic eggs are great as long as the gut can tolerate them effectively. Utilizing apple cider vinegar and/or fresh squeezed lemon can help the body digest heavy proteins.
26. Adhami VM, Mukhtar H. Polyphenols from green tea and pomegranate for prevention of prostate cancer. Free Radic Res (2006) 40:1095–104. doi:10. 1080/10715760600796498
27. Fresco P, Borges F, Diniz C, Marques MP. New insight on the anticancer properties of dietary polyphenols. Med Res Rev (2006) 26:747–66. doi: 10.1002/med.20060
28. Heger M, van Golen RF, Broekgaarden M, Michel MC. The molecular basis for the pharmacokinetics and pharmacodynamics of curcumin and its metabolites in relation to cancer. Pharmacol Rev (2014) 66:222–307. doi:10.1124/pr.110.004044
29. Lambert JD, Elias RJ. The antioxidant and prooxidant activities of green tea polyphenols: a role in cancer prevention. Arch Biochem Biophys (2010) 501:65–72. doi:10.1016/j.abb.2010.06.013
30. Radin NS. Meta-analysis of anticancer drug structures – significance of their polar allylic moieties. Frontiers in Oncology | Cancer Molecular Targets and Therapeutics July 2014 | Volume 4 | Article 183 | 2 Lipinski Inhibition of protein unfolding in cancer Anticancer Agents Med Chem (2007) 7:209–22. https://dash.harvard.edu/bitstream/handle/1/12717509/4092357.pdf?sequence=1
31. Schramm L. Going green: the role of the green tea component EGCG in chemoprevention. J Carcinog Mutagen (2013) 4(142):1000142.
32. Shukla Y, Singh R. Resveratrol and cellular mechanisms of cancer prevention. Ann N Y Acad Sci (2011) 1251:1–8.
33. Takemura H, Sakakibara H, Yamazaki S, Shimoi K. Breast cancer and flavonoids – a role in prevention. Curr Pharm Des (2013) 19:6125–32.