Prostate Cancer Targets
VEGF [Angiogenesis], PTEN [Pro-Apoptotic], NKX3.1 [Protastatic tumor suppressor], IGF-1 [proliferation, P53 [tumor suppressor], NF-κB [inflammation] , Cyclin D1 /CDK4 / CDK6 [Cell Cycle Prog], CXCR4 , FAK [Focal Adhesion Molecule], P13k/AKT [Proliferation], RAS [proliferation], PI3K/AKT
Key Regulators: Curcumin(NKX3.1) , EGCG, Genistein, Quercetin, Resveratrol, Ashwagandha, Butein, Andrographis, Sulforaphane, Vitamin C with MSM Powder, Coffee enemas or bullets, Relaxation/Meditation [Study on key regulators] . Extras: Vitamin C, Selenium, R-Alpha Lipoic Acid, Selenium & Ginger.
Carcinogenic Causes: Loss of GST Enzyme function combined with Xenobiotic expose and inflammatory and carcinogenic diet such as Processed Meat, Milk/Dairy (IGF-1 Growth Factors), Fried Foods, Veg Oils, Fats and insufficient anti-oxidants such as Vitamin C. Many cleaning products available on the market contain’everyday’ carcinogens such as formaldehyde, nitrobenzene, methylene chloride, and napthelene, as well as reproductive toxins and hormone disruptors all cause inflammation.
Essential to go on a plant based diet raw / steamed, reduced calories will lower growth factors , which will lower RAS, & Androgenic expression, cell proliferation and PSA. Being overweight or obese increases the risk of advanced prostate cancer. Researchers have found a link between being obese or overweight and cancers being higher grade (faster growing).
Detox: Since carcinogens are instigators, detoxification is essential. Organic Juices, [Organic Ginger, Burdock, Chamomile, Calendula, Bladderwrack Teas] , Charcoal, Cilantro, Spirulina, Wild Blueberry Juices ( All must be organic).
Prostate Cancer Background
Prostate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of key molecular alterations in prostate-cancer cells implicates carcinogen defenses (GSTP1), growth-factor-signaling pathways (NKX3.1, PTEN, and p27), and androgens (AR) as critical determinants of the phenotype of prostate-cancer cells. Glutathione S-transferases are detoxifying enzymes. Glutathione S-transferase P1 (GSTP1) is markedly downregulated in prostate cancer and prostatic intraepithelial neoplasia compared to normal prostate tissue. Downregulation of GSTP1 may, therefore, be an early event in prostate carcinogenesis.
Cells of prostatic intraepithelial neoplasia, devoid of GSTP1, undergo genomic damage mediated by carcinogens such as pesticides and other chemical toxins. NKX3.1, PTEN, and p27 regulate the growth and survival of prostate cells in the normal prostate. Inadequate levels of PTEN and NKX3.1 lead to a reduction in p27 levels and to increased proliferation and decreased apoptosis. Androgen receptor (AR) is a transcription factor that is normally activated by its androgen ligand. During androgen withdrawal therapy, the AR signal transduction pathway also could be activated by amplification of the AR gene, by AR gene mutations, or by altered activity of AR coactivators. Through these mechanisms, tumor cells lead to the emergence of androgen-independent prostate cancer.
Several investigators have speculated that the early loss of GSTP1 function leads to increased vulnerability to oxidant and heterocyclic amine carcinogens, both implicated in prostate carcinogenesis. [R] Nelson and colleagues demonstrated that GSTP1 overexpression confers partial resistance to the cytotoxic effects of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5- b]pyridine, the most abundant mutagenic heterocyclic amine found in cooked meats.17 It is therefore also possible that heritable differences in GSTP1 function may also be associated with prostate cancer development. Oxygen radicals can attack DNA directly and result in the accumulation of potentially promutagenic oxidized DNA bases such as 8-hydroxydeoxyguanosine. In addition, chronic oxidant stress may also result in lipid peroxidation and the subsequent generation of a range of reactive products that can damage DNA [R]. Disruption of certain genes may result in cellular tolerance to oxidative genomic injury. To increase the function of GST, Coffee enemas and coffee bullets are most effective.