The Most Potent Estrogen Inhibitor
This supplement is a safe form of a calcium salt derived from d-glucaric acid. You can find this derivative in various fruits and vegetables, and it is made in small quantities in our bodies. It is present in the following foods: apples, apricots, citrus fruits, cherries, grapefruits, broccoli, Brussels sprouts, and alfalfa sprouts.
Calcium D-glucarate is readily absorbed, active in small doses and bio-available in the body for relatively extended periods of time with many health benefits. Let’s talk a look at some of the known advantages of this phytonutrient.
Download the Calcium D-Glucarate Reference Sheet
When selecting supplements, I look for the most effective, pure, and targeted ones I can find. One of my top supplements is calcium-d-glucarate. But it has other health benefits. It can fight cancer, decrease LDL cholesterol, assist in protein digestion, and remove toxins and excess estrogen. Excess estrogen is a problem for everyone, but an even bigger problem for obese (or formerly obese) people.
Calcium d-glucarate works by metabolizing an excess of estrogen in the body and helps the liver to metabolize hormones which is necessary for both males and females. Increased estrogen will interfere with testosterone in men and lead to severe hormone imbalances in women. It is incredibly vital to balance hormones for overall health and wellness and so hard because of all the environmental foreign mimickers. Calcium d-glucarate accomplishes this difficult task by fortifying the liver and detoxifying unwanted hormones.
Therefore, it helps to protect the body against hormone mimickers, such as plastics, eliminates toxins and wastes from the body, and regulates hormone levels.
To understand why CDG works, you have to understand a little biochemistry.
How The Body Gets Rid Of Toxins
One of the ways the body gets rid of toxins is through a process called conjugation. During conjugation, toxins are packaged into water soluble compounds called glucuronides. Glucuronides are meant to pass from the liver, to the bile, then to the gut where they are excreted. However, high levels of an enzyme called beta-glucuronide can inhibit this process. This enzyme separates toxins from their conjugate bond and allows them to be reabsorbed. This allows toxins to keep circulating in the body where they make you fat, tired, and weak.
Calcium-d-glucarate prevents beta-glucuronide from disturbing this process. It keeps the toxins bound inside a glucuronide which is then removed from the body. Toxins are most damaging in their free form, which is why you want them to be bound (conjugated) and released from the body. Calcium-d-glucarate inhibits beta-glucuronidase which allows toxins to be removed.
Calcium-d-Glucarate (CDG) is a natural substance produced by all mammals, including humans. Small amounts are also found in fruits and vegetables. Early humans were able to get enough calcium-d-glucarate from their own production since they ate relatively low amounts of toxins and lived in a clean environment. As toxin exposure has increased, humans need more calcium-d-glucarate to excrete the extra toxins.
There is no *technical* deficiency of calcium-d-glucarate because it is not essential. However, humans produce small amounts, so it’s easy to develop low levels. Low levels of CDG are correlated with higher levels of beta-glucuronidase. Elevated beta-glucuronidase is a risk factor for cancer, especially hormone related cancers like breast, prostate, and colon cancer.
Here are four reasons calcium-d-glucarate is a seriously useful supplement1.
1. Cancer Prevention
Toxins cause mutations in DNA which leads to cancer. Along with retinoids, CDG reduces breast cancer in rats by 70 percent.1
Calcium-d-glucarate removes carcinogens and other tumor promoting agents. In vivo, CDG,
“…increases detoxification of carcinogens and tumor promoters/progressors by inhibiting beta-glucuronidase and preventing hydrolysis of their glucuronides”
Calcium-d-glucarate increased toxin release and flushed out compounds that promote cancer. In rats with colon cancer, calcium-d-glucarate caused a sixty percent drop in tumor incidence. CDG also reduced the number of times cancer cells multiplied.
One of the reasons smokers develop lung cancer is believed to be low levels of D-glucaric acid. Smokers have 29 percent less d-glucaric acid than healthy people. Another study in rats showed that calcium-d-glucarate decreased skin cancer formation by 30 percent.
We know without a doubt that a diet high in fruits and vegetables has many benefits and helps to decrease the chance of certain degenerative diseases and cancers. This is due to many reasons including phytonutrients that are in fruits and vegetables. One of these compounds is calcium d-glucarate. It does this by suppressing cell proliferation that we see in cancer situations and also reduces chronic inflammation by decreasing the level of inflammatory cytokines in the body.
Research shows that it lowers cancer risks. So much so that the AMC Cancer Research enter even recommends calcium d-glucarate.
Calcium-d-glucarate is not guaranteed to prevent cancer, but everything helps.
2. Liver Detox
When calcium-d-glucarate is taken orally, it’s metabolized into glucaric acid. This is the active form of calcium-d-glucarate and the one produced naturally by the body. Glucaric acid is not available as a supplement by itself which is why you have to buy calcium-d-glucarate. Another benefit of CDG over glucaric acid is a longer detox period. CDG detoxes the liver for five hours instead of one.
Glucaric acid binds to toxins in the stomach which are then removed in the urine. Glucaric acid is also circulated around the body where it performs the same function – scavenging and releasing toxins. Removing toxins from the liver will increase liver function and promote a healthy metabolism. It will also allow your liver to flush out other toxins that would otherwise cause problems.
Bonus Feature: Dealing With High Protein Problems
Humans are meant to eat large amounts of protein and fat. Our livers and kidney efficiently process proteins and are able to remove harmful byproducts like ammonia. However, humans can only handle so many toxins. The human body is involved fending off xenoestrogens, air pollutants, chronic infections, and mycotoxins. This leaves very little room for dealing with the metabolites of protein. Our modern world is so polluted, that humans don’t always have the necessary means to fend off natural byproducts of a healthy metabolism. If you’re consuming a high protein diet (25-35 percent), you should consider supplementing with calcium-d-glucarate.
3. Removing Excess Estrogen
High levels of beta-glucuronide increase the number of estrogen receptors. This means estrogen that would have been excreted is now able to bind to more receptors. This can cause increased tissue growth, cancer, and even man boobs.
Estrogen dominance is one of the leading causes of infertility, cancer, and other health problems in women. One of the most common treatments for high estrogen levels in a drug called tamoxifen, however, Tamoxifen has numerous side effects including stroke, blood clots, uterine cancer, and cataracts.
New research is showing that CDG could be just as effective as Tamoxifen in treating estrogen dominance.
CDG allows excess estrogen to be passed out of the body. A review in 2003 said calcium-d-glucarate could be as effective in preventing cancer as Tamoxifen.
In one study, calcium-d-glucarate was able to reduce the number of estrogen receptors by 48 percent. It’s also been shown to lower serum estrogen levels by 23 percent.
High estrogen is also a problem for men. Whether your a man or woman, calcium-d-glucarate will help maintain proper hormone balance.
4. Decrease LDL Cholesterol
Despite the numerous health effects of a paleo diet, one of the mysterious negative effects seems to be elevated LDL cholesterol. Paul Jaminet wrote an excellent post on this topic where numerous people said they experienced high LDL levels.
Not only is total cholesterol increased, but it’s LDL cholesterol. This isn’t necessarily a bad thing as long as it’s type-A LDL (large, puffy, non-atherogenic). However, since being Bulletproof means doing everything possible to ensure optimal health, this is something that needs to be dealt with. High LDL isn’t necessarily the problem. It’s a sign of tissue damage or toxins which is the problem.
When cells are stressed or damaged, they need cholesterol for repair. As Dr. Jaminet also pointed out, high LDL levels are needed to repair damaged tissue.
The body sends LDL molecules to supply various parts of the body with cholesterol and fats. Limited blood flow is one form of stress. Calcium-d-glucarate is metabolized into glucaric salts. Glucaric salts reduces beta-glucuronidase production by gut bacteria. Reducing beta-glucuronidase enhances enterohepatic (liver) circulation which reduces cholesterol synthesis. This causes lower cholesterol levels.
In rats, CDG lowers total cholesterol by 12-15 percent, and LDL cholesterol by 30-35 percent. In humans, CDG lowers cholesterol by 12 percent, and LDL cholesterol by 28 percent. It can also lower triglycerides up to 43 percent.
CDG is not arbitrarily playing with cholesterol numbers like statins. It decreases stress on the liver which lowers your need for cholesterol, especially LDL cholesterol.
Dosage & Side Effects
A normal detox dose is 500-1000mg. People with cancer or high estrogen may benefit from taking as much as 3000-4500mg a day. It doesn’t really matter when you take it.
Decrease the possibility of cancer
Even though there are so many benefits to this supplement, it is not possible to get the amounts of glucaric acid that are necessary to thrive from food alone and humans produce only small levels of calcium d-glucarate. Back in the day, these small amounts of natural glucaric acid was enough when we lived in an environment with low toxins and ate a clean and natural diet. But, unfortunately, we now live in an environment where we need additional support against toxins and hormone mimickers.
Therefore, we need supplementation at a higher dose. The research recommends to take at least 200-400 mg/day. It is also okay to go for a higher dose because it is a natural substance and essentially nontoxic. Most research shows that the therapeutic dose is closer to the 1500-3000 mg/day.
I like to actually utilize calcium d-glucarate with other supplements to help balance hormones and detoxify through multiply pathways. My favorite supplements to balance hormone levels are calcium d-glucarate, DIM, Indole-3-carbionol and green tea extract.
CDG can interact with alcohol and some drugs that act on the liver like statins. WebMD has the full list of possible interactions listed here.
By taking this one supplement, you can decrease your risk of cancer, remove toxins, ensure healthy liver function, and lower your LDL and total cholesterol. Calcium-d-glucarate is one of the safest, most effective biohacks available.