Bindweed or Convolvulus arvensis is a commonly found weed and every farmer’s nightmare – damaging crops by wrapping itself around plants such as corn and wheat. Bindweed grows all over the world – from Europe to China, and from Canada to South America. Farmers actually refer to it as “the cancer of weeds” – an ironic nickname. This amazing weed has demonstrated powerful angiogenesis inhibiting properties – testing 100 times stronger than shark cartilage.
With this kind of data, the potential for patients is enormous: a patient could take just 2 capsules per day of this extract versus the equivalent of 200 capsules of shark cartilage per day.
The bindweed is grown in Wyoming, and the toxic alkaloids are removed by a proprietary process.
“was found to have potent anti-angiogenic and tumor inhibitory effects. Inhibition on angiogenesis was from 18–73%. Inhibition of tumor growth was 35–80% in the cancer models represented and lymphocytes were increased 12–46% in respective models” ~ pubmedPMC2646934
As a dietary supplement, 2 to 12 capsules daily or as directed by a healthcare practitioner. The extract and capsule size matches dosage requirements of VascuStatin. Sensitive individuals may want to start with a lower dose.
Most doctors prescribe a dosage that equals the usage of 240 to 360 capsules per month.
Each 2 capsules contain: Bindweed (Convolvulus arvensis) extract 500 mg.
Caution: Contraindicated in conditions where vascular formations are desirable, i.e. heart disease, an active healing wound. Do not take for 2 weeks before and after surgery, or during pregnancy or lactation. Contraindicated for infants, children and adolescents. Use only under the supervision of a healthcare practitioner.
Other ingredients: Gelatin, maltodextrin.
100 Times Stronger Than Shark Cartilage
The proteoglycan mixture (PGM) found in bindweed has tested 100 times more effective than shark cartilage by weight. Using chicken egg chorioallantoic membrane tests, PGM was found to inhibit angiogenesis from 18% (for doses of 50 mcg per egg) to 73% (for doses of 200 mcg per egg). See photos and charts.
The Mechanism Behind The Weed
Researchers at the Center for the Improvement of Human Functioning in Wichita, Kansas have conducted numerous studies on PGM to identify the mechanisms behind its anti-neoplastic effects: There are only a handful of possible mechanisms to look for: immune stimulation, apoptosis induction; redifferentiation; angiogenesis inhibition; and the direct killing of tumor cells PGM works as an angiogenesis inhibitor” – Neil Riordan, PA-C, M.S.
Moderate Immune Stimulation
In addition to its angiogenesis inhibiting properties, PGM is also a moderate immune stimulator. Studies done on PGM’s effect on human lymphocyte growth in vitro have demonstrated an increase in lymphocyte production from 35 to 46 percent. Physicians working with cancer patients are reporting positive results consistent with this data. See ‘What Doctors Are Saying after this article.
Numerous animal studies have been performed to determine the toxicity of bindweed extract. At the equivalent of 1400 grams of PGM for humans, no toxicity was found in test animals. However it is important to note that bindweed, before the extraction process, does contain toxic alkaloids.
PGM is a potent angiogenesis inhibitor with mild immune stimulating properties, such as stimulating lymphocyte production. In animal studies, faster results occurred when an immune stimulant was added to the PGM. PGM is currently being studied as an adjunct to chemotherapy and immunotherapy at the Biocommunications Research Institute in Wichita, Kansas.
The statements made herein have not been evaluated by the US. Food and Drug Administration This product is not intended to diagnose, treat, cure, or prevent any disease.
Anti-angiogenesis properties of a common weed, convolvulus arevensis (PGM)
Research on EndoStatins and AngioStatins
Anti-Angiogenic, Anti-Tumor and Immunostimulatory
Effects of a Non-Toxic Plant Extract (PGM)
Riordan NH, Meng X, Riordan HD.
Presented at Comprehensive Cancer Care 2000, Arlington, Virginia, June, 2000.
Recruitment of new blood vessels plays a crucial role in tumor survival and growth. Several agents that act as angiogenesis inhibitors are currently being investigated as anti-tumor agents. Proteoglycan extract (PGM) was tested for anti-angiogenic, immunostimulatory, and anti-neoplastic activity. PGM is a non-toxic extract of the ubiquitous plant, Convolvulus arvensis. In the chicken egg chorioallantoic membrane assay PGM inhibited new blood vessel growth in a dose dependent manner. Results were 18, 55, and 73% inhibition at concentrations of 50, 100, and 200 mcg. respectively.
PGM significantly inhibited tumor growth in the mouse fibrosarcoma (S180 Kun Ming 3-4 week old mixed male/female, 10 animals per group, 2501000 mcg. daily doses for 14 days), and mouse Lewis Lung Carcinoma (C57, 6 wk old mixed male/female, 10 animals per group, 2501000 mcg.
Daily doses for 14 days) models. Inhibition (5477% inhibition by weight compared to controls, up to 96.8% by cellular composition) occurred regardless of route of administration: intravenous, intraperitoneal, subcutaneous, and oral. PGM induced lymphocyte growth in a dose dependent manner. The ability of PGM-treated phagocytes to phagocytose yeast cells was 85% greater than controls. We conclude that PGM is a potent angiogenesis inhibitor that has immunostimulatory activity in vitro and anti-tumor activity in vivo and that PGM should be studied further as an antineoplastic agent.
Every aspect of tumor growth requires vascular growth. In 1971 Folkman hypothesized that controlling angiogenesis could be a feasible anti-tumor strategy. Recently the description of angiostatin and endostatin has resulted in increased interest in angiogenesis inhibitors as anti-tumor agents.
Because of an anecdotal report of complete remission in a case of human ovarian carcinoma after consumption of ‘an extract of the ubiquitous plant Convolvulus arvensis, we tested extract of this plant for anti-angiogenesis and immune stimulating effects.
Convolvulus arvensis is well known to contain toxic alkaloids. Therefore, in this study we examined a high molecular weight water extract of the plant that does not contain appreciable concentrations of alkaloids, which are depleted in the manufacturing process. The extract is primarily comprised of proteoglycan molecules and is herein referred to as PGM.
Summaries of Animal & Human Studies
See following pages for summaries and results of several significant animal and human studies conducted by the above researchers
Research has been presented demonstrating that an extract of the plant Convolvulus arvensis has potent angiogenesis inhibiting and immune-stimulating qualities. This extract also demonstrated anti-tumor effects in two mouse tumor models. The exact details regarding the anti-angiogenesis mechanism of bindweed extract are not completely understood. This extract should be studied further to elucidate its anti tumor effects and mechanisms of action. .
|Chicken Egg Chorioallantoic Membrane Assay
Angiogenesis was inhibited in a dose dependent manner by PGM. The results are summarized in Table 1. Images of two chorioallantoic membranes are shown in the photos below.
Mouse Sarcoma Model
The tables below summarizes data for subcuntageous, intravenous, intraperitoneal, and oral PGM in the S-180 tumor model. p<0.1 for all subsets.
Mouse Lewis Lung Carcinoma Model
PGM inhibited tumor growth in the Lewis Lung Carcinoma model by 62% at the highest concentration injected, 1000 mcg/day (p<.001).
Human Lymphocyte Proliferation
Lymphocytes proliferated in a dose-dependent manner to the PGM. The results are summarized in the table below.
Amount injected and route of administration
(po=orally sq=subcutaneous ip=intraperitoneal iv=intravenous)
What Doctors are Saying
“We have been in practice for 15 years and are always looking for something that works. It has been my experience that if bindweed extract does not shrink a tumor, it will arrest its growth it stops the progression of the disease, which buys valuable time to add additional therapies. Every one of our patients that has used it in their treatment protocol has had a positive effect. We recently had an experience with a Stage IV breast cancer patient with metastases to the liver and bone. In addition to traditional cancer treatment, the patient used bindweed extract, along with a number of other natural protocols. The growth of her tumors stopped and her markers went down from 950 to 530 in the first 45 days.
She had been labeled terminal, but instead, she has been given the time to completely change her outlook on life. It has always been our feeling that if we can give people more quality of life and a little more quantity if we can minimize their suffering, then we’re doing well. PGM has definitely helped us accomplish that goal.”
Jeff Marrongelle, DC
“PGM seems to be responsible for a lot of positive changes in my patients’ cancer treatment. My patients also report that they feel better and experience a reduction of symptoms on PGM.”
Mary Shackelton, ND
“Clinically, I think the bindweed extract is a very interesting substance. We have observational clinical evidence so far that it is an effective angiogenesis inhibitor. We have been unable to study this in a research sense as yet. I think PGM has a very exciting future. We also find that it is much better tolerated than shark cartilage. In terms of electrodermal testing, PGM consistently tests better than the two other main angiogenesis inhibitors, shark cartilage and thalidomide.”
Julian Kenyon, MD, MB, ChB, Medical Director
A woman with ovarian cancer came into our research office seven years ago and said she felt she had to talk to someone about this weed. Her medical doctor wasn’t particularly interested in it and she felt that it could help a lot of people. After being given a death sentence of only one year to live, she decided to take the tincture of bindweed. That was seven years before coming to our office.”
Neil Riordan, PA-C, M.S.
Letter From A Patient
November 24, 2000
On June 5th of this year, I went into surgery for a planned Whipple procedure (removal of pancreas duodenum for pancreatic cancer). After the exploratory laparotomy, it was found that the tumor of the common duct extended along the portal, into the liver and was felt to be unresectable. The surgeons took samples to biopsy, which confirmed invasive adenocarcinoma of the pancreas -Stage IV. They offered radiation and chemotherapy, not as a cure, but as a possible short-term life extension of an additional month or two. Without this option, they told me, I might only live one to three months. Having the background in nursing that I do, I quickly turned down this therapy and went home.
All of my nutritional supplements were immediately increased and many others added, including Beta 1-3 Glucan, IP6, and enzymes. In addition, I was taking Vitamin E, CoQ10, selenium, lipoic acid, calcium, magnesium, MSM, niacinamide, and I increased my oral Vitamin C to 16 grams per day. After July 27th, I started on WPGC (Muramyl polysaccharide-glycan complex) and increased my lipoic acid. It was evident that despite all of the supplements I was taking daily, including large amounts of intravenous Vitamin C, the tumor was growing. Due to the hardness of the tumor, I could feel its outline. My liver was 3 fingers below the ribcage.
On September 29th, I started another supplement – PGM, taking 28g. daily. After 7 days on the PGM, I noticed a change- there was a reduction in the size of the tumor. On October 6th, I increased the daily dose of PGM to 56g. On October 7th, my pitting edema, which was about a 1+ in my ankles and legs, along with some fluid buildup around my abdomen – disappeared. On October 11th, twelve days after starting the PGM, the hard area (or rim of the tumor) had decreased about a quarter of an inch; and behind the bard rim, about one half was spongy to the touch. After a stent replacement on October 26th, my doctor said he noticed the tumor decreasing in size. Once a week, I continued to examine myself and noticed the size of the tumor decreasing. By November 19th I could no longer feel the tumor and my liver has returned to its normal size. Thank you for this opportunity.
Most doctors prescribe a dosage that equals the usage of 2 to 3 bottles (240 to 360 capsule) per month.
|Herbal Extract Inhibits Angiogenesis
Contraindicated in conditions where vascular formations are desirable, i.e. heart disease, an active healing wound. Do not take for 2 weeks before and after surgery, or during pregnancy or lactation. Seek the advice of a health care practitioner before using this product.
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