Ingredients within BoneMaker Herbal Tonic:
- Poria Cocos – shown in a Korean study to suppress bone resorption of mature RANKL-mediated osteoclasts
- Psoralea corylifolia – increases new bone formation and has positive effects on bone mineral density
- Camellia Sinensis – Initiates bone formation, improves bone mineral density and decreases the risk of fracture
- Dioscorea – Enhance Kidney Essence, strengthens bone structure, soothes lower back pain, reinforces Kidney jing,
- Atractylodes – has protective effect, inhibits osteoclast differentiation and may prevent various bone diseases
- Epimedium – phytoestrogen flavonoids shown to prevent bone loss in late postmenopausal women without side effects.
- Eucommia – studies show it may initiate osteoblast, enhance osteogenesis, decrease osteoclast and prevent osteolysis
- Nettle (Urtica dioica) – inhibits inflammatory cascade in autoimmune disease and rheumatoid arthritis, inhibits TNF-alpha and IL-1 beta, accelerating new bone formation and reducing inflammation and preventing relapse.
- Panax Ginseng – protects against osteoporosis and inflammation-induced bone loss – ginseng saponins (ginsenosides) has beneficial effects on osteoporosis and may increase the osteogenesis of bone marrow stromal cells and pre-osteoblast cells.
- Ligustrum – antiosteoporotic compounds in Ligustrum were shown to increases the bone mineral density
- Corydalis – not only induces apoptosis of mature osteoclasts, but also increases differentiation of osteoblasts.
- Bupleurum – Inhibits Osteoclastogenesis in Bone Marrow-Derived Macrophages and Osteolytic Activity of Metastatic Breast Cancer Cells
Osteoporosis and bone erosion is an aging problem. The declining bone mineral density (BMD) enhances the chances of fractures during minor falls. Effective pharmaceuticals are available for a rapid improvement of BMD.
[BoneMaker is part of the Bone-Rescue Protocol]
However, it can also be a consequence of taking synthetic aromatase inhibitors for cancer treatment too, an all too common occurrance these days.
As for conventional so-called solutions to bone resorption, hormonal treatment gives serious complications, and bisphosphonates may lead to fractures of long bones, resulting from excessive rigidity of the cortical components.
Third-generation synthetic aromatase inhibitors (AI’s; that is, anastrozole, letrozole and exemestane and now denosumab) have become the standard of care for the adjuvant treatment of hormone-responsive breast cancer in postmenopausal women. Since denosumab, like the bisphosphonates, prevents normal bone remodeling, one would expect the denosumab twins, Prolia and Xgeva, to produce similar adverse effects, and they do. Far fewer studies tracking outcomes are available in comparison to the bisphosphonates because denosumab obtained FDA approval as Prolia in June 2010, and within two years denosumab was found to cause osteonecrosis of the jaw.
For many years, tamoxifen was the cornerstone of endocrinetherapy. However, recent clinical trials of AIs have shown benefits over tamoxifen. The main advantages are improvement of disease-free survival, decreased rates of contralateral breast cancer and a more favorable toxicity profile, with lower rates of thrombo embolic phenomena and endometrial malignancy.
However, these trials reported incidences of musculoskeletal symptoms ranging from 5% to 35%. Observational studies, have shown that aromatase inhibitor-associated musculoskeletal symp-toms (AIMSS) are more prevalent than originally reported [9,10]. In a cross-sectional survey of 200 women receiving adjuvant AI therapy for breast cancer, 94 (47%) reported AI-associated joint pain, and 88 (44%) reported joint stiffness; nearly 13% of patients discontinued therapy because of intolerable musculoskeletal symptoms. Because the mechanisms mediating AIMSS are not clearly understood, effective management of AIMSS has not yet been developed.
Potential interventions for AIMSS usually include non-steroidal anti- inflammatory drugs, analgesics , calcitriolagents, vitamin D, and exercise. Some patients even have to switch AIs or switch to tamoxifen because of severe musculoskeletal symptoms [11,12]. However, it is not clear whether any of these interventions have had a dramatic effect on musculoskeletal symptoms.
What can be done?
Many medicinal herbs used in Traditional Chinese Medicine, known as kidney tonics, have been tested for their effects on bone metabolism in the laboratory and clinically.
According to Chinese Medicine, “The vital essence or kidney yin function is the material basis for reproduction, growth and development, formation of the bone marrow, nourishment of the brain and bones.” (1) Deficient kidney yin is manifested with symptoms of aching, soreness of the lumbar region of the back, weakness of the legs and knees, tinnitus, feverish sensation in the soles and palms, nocturnal emission, and in women, scanty menstrual flow and amenorrhea. Deficient liver yin has dizziness, tinnitus, dryness of the eyes, blurred vision, irritability and irascibility. The tongue is reddish with little or no coat. The pulse is wiry, rapid or thready.
The nature of all these symptoms are chronic and wasting and reflects a tendency which we in the West commonly understand as “burnout” neuresthenia or adrenal fatigue. There is also a difference between the ongoing condition of “yin deficiency” which many chronically have and what I call the occasional `exhausted yin’ caused by the stresses and ordeals of normal living.
Liver qi depression leads to stagnation of qi movement, manifested as pain. Insufficient kidney essence results infailure to nourish the related body constituents and organs, including bone and joints. Kidneys govern the bones and teeth.
BASIC SIGNS OF TCM KIDNEY IMBALANCE
According to TCM differential diagnosis, one must have at least three prominent symptoms from the following:
- low back pain joint and knee pains
- stiffness impotence or frigidity
- libido hearing
- head hair urinary problems
- growth and maturation bone and marrow problems
Kidney Yang becomes the reactive, sympathetic nervous system relating to the secretion of epinephrine and norepinephrine from the adrenal medulla as well as other yang-izing hormones from the pituitary, thyroid and other endocrine glands. In contrast, Kidney Yin is the parasympathetic nervous system relating to the secretion of corticosteroids from the adrenal cortex as well as other yin-izing hormones secreted by the anterior pituitary and other endocrine glands.
Through the use of the herbs within BoneMaker and the additional ingredients within the Bone-Rescue Protocol which assist in the repair and re-building of bones, which according to therapeutic principle of TCM, would tonify the kidney, fortify the bone, soothe the liver, regulate qi and unblock the collateral, we hypothesise that AIMSS could be partly relieved in practice over a period of weeks and months, provided that the instigator of the bone damage has been removed from regular usage.
The Herbal Ingredients within Bone Maker
A recent discovery regarding Estrogen regulation of bone resorption has identified that three new members of the TNF ligand and receptor signaling family that serve as the final effectors of osteoclast(OC) differentiation and function. The long-sought osteoblast-derived paracrine effector of OC differentiation has been identified as the receptor activator of NF-kB ligand (RANKL, also called OPG ligand or OC differentiating factor) , therefore TNF-a and IL-1 must be inhibited simultaneously if bone loss is to be prevented. 
Several years ago, German researchers discovered that a traditional European herbal remedy for rheumatism, (urticae dioicae foliorum) nettle leaf extract, inhibits TNF-alpha and IL-1 beta. Nettle “may inhibit the inflammatory cascade in autoimmune diseases and rheumatoid arthritis,” concluded a team of researchers . It is interesting to note that the prescription drug Enbrel®, approved for the treatment of rheumatoid arthritis, also acts by suppressing TNF-alpha. 
One of the ways Nettle leaf extract blocks proinflammatory signaling by inhibiting the genetic transcription factor that activates TNF-alpha and IL-1 beta in synovial tissue. This proinflammatory transcription factor, known as nuclear factor kappa beta (NF-kb), is elevated in chronic inflammatory diseases and is essential to activation of TNF-alpha. Nettle is thought to work by preventing degradation of the natural inhibitor of NF-kb in the body. TNF-alpha also activates NF-kb in synovial cells, leading to the suggestion that a cycle of cross-activation between TNF-alpha and NF-kb and may sustain and amplify the disease process in rheumatoid arthritis. 
In recent studies, some bioactive compounds such as Green tea polyphenols, carotenoid and lycopene could help alleviating bone loss induced by estrogen deficiency in post-menopausal women [15-16]. The common pharmacological activity of these compounds is to scavenge oxygen free radicals . It has been demonstrated that oxidative stress is one of the contributing factors to osteoporosis In an animal study  a supplementation of Green Tea Polyphenols (GTP) in the drinking water significantly increased Bone Mineral Density, serum OC, and trabecular volume fraction and number in both the femur and tibia, but decreased serum TRAP, eroded surface, and osteoclast number in endocortical tibial shafts.
Ingredients: extracts of Poria Cocos, Psoralea, Camellia, Dioscorea, Atractylodes, Epimedium, Eucommia, Nettle, Ginseng, Corydalis, Ligustrum and Bupleurum in 30% alcohol. 1:3 (root: alc).
Inhibition of Osteoclast Differentiation and Bone Resorption by Poria cocos Wolf Extract.
Camellia sinensis Amplification by (-)-epigallocatechin gallate and chlorogenic acid of TNF-a-stimulated interleukin-6 synthesis in osteoblasts
Poria Cocos (Fu Ling)
Psoralea corylifolia extract ameliorates experimental osteoporosis
Ethanol extract of Atractylodes macrocephala protects bone loss by inhibiting osteoclast differentiation.
has a protective effect on bone loss via inhibiting osteoclast differentiation and suggest that AMEE may be useful in preventing and treating various bone diseases associated with excessive bone resorption.
Epimedium-derived phytoestrogen flavonoids exert beneficial effect on preventing bone loss in late postmenopausal women
Nettle (Urtica dioica) inhibits inflammatory cascade in autoimmune disease and rheumatoid arthritis, inhibits TNF-alpha
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