Humans need 13 different vitamins to sustain life and health. If we do not take in enough of a particular vitamin our bodily supplies decrease and a deficiency ensues.Click here to See our other Suitable MM Products
Of the 13 vitamins our bodies need, one is B12. It is unique because it is the only vitamin that cannot be obtained from plants or sunlight (as plants do not need B12, so do not produce or store it), it is produced by bacteria in the gut of animals and absorbed in the small intestine.
It is remarkably easy to become deficient in B12, as many people can neither absorb nor use B12 due to gut disturbances. Vegans and vegetarians are particularly prone to deficiency. The route that B12 takes from the mouth to the blood is very complex and there can be problems at any point. Which is why sublingual administration can be very effective as it enters directly into the bloodstream.
B12BIACTIVE contains lab-generated forms of B12… Methylcobalamin(80%) and Adenosylcobalamin(20%)
Therefore to obtain B12 from the diet you need to eat animal products- meat, fish or dairy products. However even a diet high in these foods may not supply enough B12. In fact it is remarkably easy to become deficient in B12 as many people can neither absorb nor use B12. Vegans and vegetarians are particularly prone to deficiency. The route that B12 takes from the mouth to the blood is complex and there can be problems at any point.
Metabolic Effects of B12 :
- Reduces Tiredness
- Supports Nervous System
- Assists Blood Formation
- Supports Proper Cell-Division
- Helps Homocysteine metabolism
The steps of the B12 pathway are:
- Food containing B12 is bound to animal proteins and needs to be freed. So when the food reaches the stomach it is split by an enzyme Pepsin (produced in the stomach only if sufficient amounts of Hydrochloric acid)
- The stomach also produces intrinsic factor (IF) , a protein that is needed later in the pathway.
- Other proteins known as R-Binders carry the B12 into the small intestine.
- In the intestine, intrinsic factor (from the stomach ) attaches itself to the B12 and transports it to the last section of small intestine, the ileum. The cells lining the ileum contain receptors that grab onto the B12-Intrinsic factor complex and drag it into the blood stream
- In the bloodstream, another protein, transcobalamin2 carries the Vitamin B12 to all the cells in the body, transporting any extra to the liver for storage.
The most-commonly used man-made forms are cyancobalamin, methylcobalamin, and hydroxocobalamin. Hydroxycobalamin is the form of vitamin B12 that the “good” or “healthy” bacteria in your gut make on their own. Methylcobalamin is the form of vitamin B12 that’s the easiest for the body to use. Methylcobalamin is optimally bioeffective. Adenosylcobalamin plays a critical role in mitochondria, methylation tolerance, myelin formation, and neurological health and is often lacking in the diet.
The most well studied use of methylcobalamin has to do with sleep. Although the exact mechanism of action is not yet clear, it is possible that methylcobalamin is needed for the synthesis of melatonin. Available information indicates that methylcobalamin can modulate melatonin secretion, enhance light-sensitivity, and normalize circadian rhythm (your 24-hour clock). Because of this, individuals supplementing this form of B12 often have improved quality of sleep, often will require slightly less sleep, and will not uncommonly report that they feel a bit more refreshed when waking in the morning. Methylcobalamin is particularly effective when your 24-hour clock is not running smoothly.
Adenosylcobalamin is also an “active” B12 form, making this coenzyme immediately available for use by the body. It is required for an enzyme known as MCM (Methylmalonyl Coenzyme A Mutase), which resides in the mitochondria and is needed to make succinyl CoA to produce energy in the citric acid cycle. In humans adenosylcobalamin is found mainly in the tissues especially the liver. It is the primary form on B12 found in non-human animals.Deficiency of Vitamin B12 There is no one particular symptom that suggests a B12 deficiency. Symptoms may depend on the age and genetic disposition of the individual, and also the length and severity of deficiency.
Because Vitamin B12 has so many functions, including the health of nerves, brain, blood and immune system, as well as the formation of DNA, B12 deficiency can impair functioning in almost any part of the body. The following signs and symptoms are common symptoms of B12 deficiency but can also arise from other causes.Mental changes include irritability, apathy, sleepiness, paranoia, personality changes, depression, memory loss, dementia, hallucinations, violent behaviour and in children developmental delay and/or autistic behaviour.
Neurological signs and symptoms include pain, tingling or numbness, decreased sense of touch, pain or temperature, weakness, loss of awareness of body position, clumsiness, tremor, symptoms mimicking Parkinson’s disease or multiple sclerosis, spastic muscles, incontinence, paralysis, visual changes and damage to the optic nerve.
Vascular changes include, transient ischaemic attacks (TIAs or mini strokes), CVA or stroke, coronary artery disease, heart attack, congestive heart failure, palpitations, low blood pressure when standing causing fainting, deep vein thrombosis (blood clot in the arm or leg) and pulmonary embolism.Other signs and symptoms may include shortness of breath, generalized weakness, chronic fatigue or tiredness, loss of appetite and weight loss, epigastric pain (poor digestion, full or bloated feeling after eating normal or small meals), diarrhoea or constipation, increased susceptibility to infection, poor wound healing, failure of new born to thrive, tinnitus, vitiligo (white patches of skin), or hyperpigmentation, premature grey hair and impotence.
These statements have not been evaluated by the Food & Drug Administration. This nutraceutical is not intended to diagnose, treat, cure or prevent any disease. IF YOU ARE NURSING, TAKING MEDICATION OR HAVE A MEDICAL CONDITION, CONSULT YOUR PHYSICIAN BEFORE USING.
It is advisable that B12 is NOT to be taken with fruit juice or with Vitamin C supplements.
Best taken in the morning on an empty stomach.
Spray B12BIACTIVE TWICE under the tongue and hold for 30 seconds before swallowing. One squirt is 850 mcg and Two squirts is 1,700 mcg. B12BIACTIVE should be supported with Folate and Magnesium Glycinate supplements.
30ML B12BIACTIVE will last approx 33 days (2 squirts per day – 1700mcg)
50ML B12BIACTIVE will last approx 55 days (2 squirts per day – 1700mcg)
All forms of B12 are stable when protected from the light. Light exposure cleaves the cyanide with the production of hydroxycobalamin. The B12’s have an optimal stability at a PH4.00-4.5, even at higher temperatures. In the presence of acid or alkaline mediator the presence of reducing agents such as ascorbic acid the vitamin is destroyed to a greater extent. It is therefore advisable that B12 is not to be taken with fruit juice.
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You Donate & We Gift
By Donating the suggested amount shown on this item, we will Gift the item to you and send it by either post or courier. If the gift/s total is over £60 in value, we will send it free of delivery charge to any British Isles (BI) addresses. If you are in a country outside of BI, our website robots will calculate your postage charge and allow you to gift that too that as part of the total. You can return unwanted items by post (at your cost) within 20 days of receipt of your items, provided they are returned unopened, (seals intact) and in their original packaging. Please contact us for the return address. You will need to cover the cost of this.
- Werone Sends Gifts Worldwide!
- Werone is not for profit
- Werone really cares about your health and that these gifts are of the highest quality
If You Change Your Mind
You can return your gift within 20 days (see left panel)
Email us for return address
Please remember to ensure that the item you are returning is repackaged with all elements, unopened and seals intact and in a re-gifting condition.
Delivery - British Isles Shipping (BI):
Donation/Gifting placed before 12pm will usually be shipped the sameday, if there is any stock issue we will contact you to discuss. The main shipping choices available during the final stage of our gifting cart are:
British Isles Delivery - FREE if over £35 order value - [£0.00] 2nd Class Royal Mail
2 to 3 Day - Monday to Friday, 'may' deliver to residential addresses on a Saturday.
British Isles Delivery - Royal Mail up to 2Kg - [£3.50 to £6.00]
Next Day - Monday to Friday, 'may' deliver to residential addresses on a Saturday.
British Isles Delivery - Courier up to 5Kg - [£7.50 to £14.00]
Next Day - Monday to Friday.
Europe / Baltics / Russia - Surface Mail up to 2Kg - [£4.56 to £13.50]
Next Day - Monday to Friday, 'may' deliver to residential addresses on a Saturday.
Outside Europe / International - [7-10 days] - Mail and/or Courier,
from £9.00 or 3 day courier service from £21]
* Please ensure that someone is available to sign for the parcel at the delivery address. You may provide a work address if you wish during the checkout process. Royal Mail will only make ONE delivery attempt, if nobody is available at the address, they will leave a card and expect you to contact them, they cannot leave with a neighbour unless you pre-arrange this with us. A re-delivery will cost £3.00 and a change of address will be £6.50, you may also collect from their collection office. If the shipment is not collected after 4 days they will return it back to us, re-deliveries will be chargeable.
Please Note: These costs are for most items. We reserve the right to adjust costs to reflect the additional cost of shipping items of greater than average weight . Shipping & Handling is based on weight of the Order using the following schedule (all donations are in GBP and not subject to VAT)
Delivery Zones Worldwide
Note, if you choose the wrong delivery zone, we will re-calculate the delivery charge and advise you by email if there is any donation shortfall to ask you to pay the balance on paypal..
British Isles / Free if not urgent! Surface Mail / Courier from £10England, Scotland, Norther Ireland, Wales, Channel Islands, I.O.M
Europe / Baltics / Russia - Surface MailIrish Republic, Belgium, France, Germany, Greece, Hungary, Italy, Netherlands, Portugal, Romania, Spain , Med. Islands , Austria, Bulgaria, Cyprus, Czech Republic, Denmark, Estonia, Finland, Hungary, Israel, Luxembourg, Lithuania, Latvia, Malta, Norway, Poland, Russia, Romania, Slovakia, Slovenia, Serbia, Sweden,
Outside Europe / Asia / USA / Southern Hemisphere - Surface Mail or CourierAfrica , Albania, Algeria, Australia, Botswana, Bahamas, Canada, Canary Islands, Croatia, Egypt, Jamaica, Jordan, Kenya, Malaysia, Mauritius, Monaco, Moldova, Morocco, South Africa, Sudan, Switzerland, Syria, Turkey, Ukraine, Zambia, Argentina, Barbados, Brazil, Chile, Colombia, Costa Rica, Equador, Israel, Jamaica, Kuwait, Libya, Lebanon, Mexico, Oman, Peru, Puerta Rica, Saudi Arabia, Singapore, Taiwan, Thailand, UAE, Uraguay, Yemen, Australia, Bali, China, Hong Kong, Indonesia, Japan, South Korea, Malaysia, New Zealand.
|Delivery Region (Regular Mail and Couriers)||Delivery Costs (Approx.)|
- FREE if over £35 order value
(5 to 7 days)
|>5kg FREE but Not Insured!|
British Isles / Royal Mail
British Isles / Hermes Courier (2 - 3 days)
|Europe + Baltics + Russia Surface Mail (approx 1 week)
|Europe / Ireland Courier ( 3 days)||
|Outside EU (approx 7 - 10 days)
(7-10 days mail
1kg £21.00 Use Cour.
|Outside EU Courier
(3 days UPS, option is insured)
Warranty and Returns PolicyWe can provide a refund if you are unhappy with your gift but you will need to pay the return costs and the individual items must not have been opened and must be returned in original condition and with all packaging intact. Any refunds which are authorised should be returned to the address on the paperwork with a copy of it along with your reason for return. Items MUST be returned in the condition they were sold in.
USA and International Gifts:Must be received before 11.00am to be despatched on the same day (note: £1 is approx $1.30 USD & €1.14 EUR, use this Currency Convertor to find the latest exchange rates)
Special Delivery are a fast and reliable service. The delivery to the British Isles is a 1-2 day service (subject to stock) when choosing these methods. We cannot 'guarantee' a nextday delivery, though often it will arrive nextday (except during Holiday Periods). Please make your choice on the checkout page of our gifting cart. Parcels weighing over 1kg in weight will automatically be sent using Courier nextday from day of despatch unless otherwise specified. Most orders placed before 12 Noon are usually be despatched sameday but we cannot guarantee this, [email us] to find out what stage of your gift is at. Donation/Gifts placed late Friday afternoon or on a weekend, will not be sent until the following Monday or Tuesday. Should you wish to have a Saturday Delivery, there is an additional cost of £18.
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- Cellular Detoxifier Enhances the major detoxification pathways in the body
- A Dietary Supplement
- Found naturally in oranges, broccoli, carrots, spinach and apples.
- Calcium D Glucarate enables the body to excrete hormones and other cellular toxins
- EUR: €24.68 - €46.62
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