- EUR: €7.13
- EUR: €9.32
Amla Powder – Phyllanthus emblica) rich in Ellagitannins
- EUR: €7.13
Phyllanthus emblica Linn. (syn. Emblica officinalis), commonly known as Indian gooseberry or amla, family Euphorbiaceae, is an important herbal drug used in unani (Graceo – arab) and ayurvedic systems of medicine. The plant is used both as a medicine and as a tonic to build up lost vitality and vigor. Phyllanthus emblica is highly nutritious and could be an important dietary source of vitamin C, amino acids, and minerals. The plant also contains phenolic compounds, tannins, phyllembelic acid, phyllembelin, rutin, curcum-inoids, and emblicol. All parts of the plant are used for medicinal purposes, especially the fruit, which has been used in Ayurveda as a potent rasayana and in traditional medicine for the treatment of diarrhea, jaundice, and inflammation. Various plant parts show antidiabetic, hypolipidemic, antibacterial, antioxidant, antiulcerogenic, hepatoprotective, gastroprotective, and chemopreventive properties.
Phyllanthus emblica is a tree indigenous to tropical regions of Southeast Asia. The tree produces a fruit commonly known as Indian Gooseberry or Amla. The Phyllanthus emblica fruit (also known as Emblica officinalis) or extract from these fruits has been used in traditional medicine for generations to treat symptoms ranging from constipation to the treatment of tumors .
Most commonly, the gooseberry was employed as a gentle laxative. However, the potential of Phyllanthus emblica extract to be utilized as an anticancer agent has been scrutinized using modern medical techniques over the past two decades. To date, there is substantial evidence that these extracts contain small molecules with both cancer-preventative and antitumor activity.
Traditionally, this ingredient was thought to have cooling, astringent and drying properties, and was used to stimulate hair growth by nourishing the hair and scalp and even preventing prematurely graying hair. The high tannin content of Phyllanthus Emblica was also used as a dye in inks, shampoos and hair oils.
More recent studies have found demonstrated, through in vitro tests, that Phyllanthus Emblica may have antiviral and antimicrobial properties. It is thought to contain very high amounts of Vitamin C, a powerful antioxidant known to reduce wrinkles, suppress pigmentation, and help skin retain its natural moisture. However, studies have shown that the “overall antioxidant strength of amla may derive instead from its high density of tannins and other polyphenols. The fruit also contains flavonoids, kaempferol, ellagic acid and gallic acid” (Wikipedia). An article published in the Journal of Ethnopharmacology found that Phyllanthus Emblica was an extract that ultimately did possess antioxidant and anti-inflammatory properties.
Taken prophylactically, Emblica officinalis extract reduced the genotoxic effects of heavy metals and the carcinogen benzopyrene in murine models [9, 10]. In a murine model of skin carcinogenesis, continuous administration of Emblica officinalis extract at 100 mg/kg reduced tumor incidence by ~60% . Similarly, two independent studies showed the polyphenol or aqueous fractions of Emblica officinalis administered at 60–250 mg/kg prevented N-nitrosodiethylamine induced hepatocellular carcinoma by ~80–100% [12, 13]. However, such dramatic results were not reported when Emblica officinalis extract was examined for chemoprevention of liver tumors induced by initiation with diethylnitrosamine followed by promotion with 2-acetylaminofluorene . This difference indicates Emblica officinalis has the capacity to prevent the onset of some, but not all cancers, depending on the initiator. This becomes fairly obvious when one considers carcinogenic compounds have differing modes of action; thus a single extract could not be expected to be universally chemopreventive. Hopefully, future studies will expand on these studies to examine the ability of Emblica officinalis to prevent tumors initiated by a wider variety of carcinogens at diverse tissue sites.
How are these extracts chemopreventive? There are four possibilities. First, Phyllanthus emblica has potent free radical scavenging activities that might prevent reactive oxygen species induced DNA damage and oncogenesis [15, 16]. However, in the animal models described above, it is unclear to what extent reactive oxygen species contribute to the underlying pathology, implying that there may be alternative mechanisms of action. Second, the extract has properties allowing it to reduce the levels of cytochrome enzymes in liver cells . Cytochromes, such as Cyp 450, convert xenobiotics to potentially carcinogenic substances in an effort to clear them from the body.
However, this concept is controversial as Amla extract was not found to decrease Cyp 450 levels in at least two other studies [18, 19]. Third, Phyllanthus emblica extracts have anti-inflammatory activities that might prevent inflammation related cancers . Finally, as we will describe below, Phyllanthus emblica harbors potent antitumor activity [21, 22]. Even exposure to low levels of extract from these berries may be enough to impair tumor progression at early stages. It should be noted that there is concern regarding potential hepatotoxicity after long term Amla ingestion . This matter may need to be resolved in the future by clinical and epidemiological studies before Phyllanthus emblica extract can be safely recommended for long term consumption for the prevention of cancer.
Phyllanthus emblica extract that have reproducibly been shown to have anticancer properties. Primarily, we will focus on the hydrolyzable tannin content of these extracts because of their high content within the Amla fruit  and importantly due to their known antioxidant, cancer-preventative, and cytotoxic activity in vivo [34, 35]. However, the flavonoid quercetin perhaps serves as the best paradigm for the future drug development from molecules within Amla extract having anticancer properties (described below), as this molecule has gone to clinical trial and novel analogues are being pursued. While there are other constituents of Amla extract such as vitamin C that have antioxidant activity, the only molecules having bona fide anticancer activity to date fall within the tannin or flavonoid categories.
The major constituents of Phyllanthus emblica that have been identified by HPLC and formally characterized as having anticancer activity are described below (and in Table 1). Overall, it seems reasonable that many of the anticancer properties of this fruit are derived from the tannin content. However, a notable exception to this concept is the flavonoid quercetin, which harbors potent antioxidant and anticancer properties as demonstrated utilizing multiple in vivo models of cancer including breast and leukemia [36–38].
|Table 1: Molecules from Phyllanthus emblica fruit extract having proven anticancer properties.
Phenolic compounds from Phyllanthus emblica extract identified by HPLC having anticancer properties Cancer model utilized to identify antiproliferative and antitumor properties
Ellagic acid (tannin) Colon, prostate cell lines, and breast and prostate xenografts
Corilagin (tannin) Ovarian cancer cells, liver cancer cells, and hepatocarcinoma xenografts
Pyrogallol (tannin) Lung cancer cells, gastric cancer cells, and lung adenocarcinoma xenografts
Chebulagic acid (tannin) Retinoblastoma colon cancer, breast cancer, prostate cancer, and leukemia cancer cell lines
Gallic acid (tannin) Breast and lung cancer cell lines, some activity against lung cancer xenograft
Quercetin (flavonoid) Numerous cancer cell lines from multiple tissue types, transgenic murine model of breast cancer, leukemia xenograft, and phase I clinical trial
For References see the References Tab above.
Anticancer Properties of Phyllanthus emblica (Indian Gooseberry) from Oxidative Medicine and Cellular Longevity
Volume 2015 (2015), Article ID 950890, 7 pages.
Therapeutic potential of Phyllanthus emblica (amla): the ayurvedic wonder.
Anticancer Properties of Phyllanthus emblica (Indian Gooseberry).
Amla powder can be added to daily smoothies and with Golden Milk (Turmeric, black pepper, coconut milk, honey, ginger, cinnamon) after the heated milk has been cooled down with some filtered water.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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References from 'Anticancer Properties of Phyllanthus emblica (Indian Gooseberry)'; http://www.hindawi.com/journals/omcl/2015/950890/
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from £9.00 or 3 day courier service from £21]
* Please ensure that someone is available to sign for the parcel at the delivery address. You may provide a work address if you wish during the checkout process. Royal Mail will only make ONE delivery attempt, if nobody is available at the address, they will leave a card and expect you to contact them, they cannot leave with a neighbour unless you pre-arrange this with us. A re-delivery will cost £3.00 and a change of address will be £6.50, you may also collect from their collection office. If the shipment is not collected after 4 days they will return it back to us, re-deliveries will be chargeable.
Please Note: These costs are for most items. We reserve the right to adjust costs to reflect the additional cost of shipping items of greater than average weight . Shipping & Handling is based on weight of the Order using the following schedule (all donations are in GBP and not subject to VAT)
Delivery Zones Worldwide
Note, if you choose the wrong delivery zone, we will re-calculate the delivery charge and advise you by email if there is any donation shortfall to ask you to pay the balance on paypal..
British Isles / Free if not urgent! Surface Mail / Courier from £10England, Scotland, Norther Ireland, Wales, Channel Islands, I.O.M
Europe / Baltics / Russia - Surface MailIrish Republic, Belgium, France, Germany, Greece, Hungary, Italy, Netherlands, Portugal, Romania, Spain , Med. Islands , Austria, Bulgaria, Cyprus, Czech Republic, Denmark, Estonia, Finland, Hungary, Israel, Luxembourg, Lithuania, Latvia, Malta, Norway, Poland, Russia, Romania, Slovakia, Slovenia, Serbia, Sweden,
Outside Europe / Asia / USA / Southern Hemisphere - Surface Mail or CourierAfrica , Albania, Algeria, Australia, Botswana, Bahamas, Canada, Canary Islands, Croatia, Egypt, Jamaica, Jordan, Kenya, Malaysia, Mauritius, Monaco, Moldova, Morocco, South Africa, Sudan, Switzerland, Syria, Turkey, Ukraine, Zambia, Argentina, Barbados, Brazil, Chile, Colombia, Costa Rica, Equador, Israel, Jamaica, Kuwait, Libya, Lebanon, Mexico, Oman, Peru, Puerta Rica, Saudi Arabia, Singapore, Taiwan, Thailand, UAE, Uraguay, Yemen, Australia, Bali, China, Hong Kong, Indonesia, Japan, South Korea, Malaysia, New Zealand.
|Delivery Region (Regular Mail and Couriers)||Delivery Costs (Approx.)|
- FREE if over £35 order value
(5 to 7 days)
|>5kg FREE but Not Insured!|
British Isles / Royal Mail
British Isles / Hermes Courier (2 - 3 days)
|Europe + Baltics + Russia Surface Mail (approx 1 week)
|Europe / Ireland Courier ( 3 days)||
|Outside EU (approx 7 - 10 days)
(7-10 days mail
1kg £21.00 Use Cour.
|Outside EU Courier
(3 days UPS, option is insured)
Warranty and Returns PolicyWe can provide a refund if you are unhappy with your gift but you will need to pay the return costs and the individual items must not have been opened and must be returned in original condition and with all packaging intact. Any refunds which are authorised should be returned to the address on the paperwork with a copy of it along with your reason for return. Items MUST be returned in the condition they were sold in.
USA and International Gifts:Must be received before 11.00am to be despatched on the same day (note: £1 is approx $1.30 USD & €1.14 EUR, use this Currency Convertor to find the latest exchange rates)
Special Delivery are a fast and reliable service. The delivery to the British Isles is a 1-2 day service (subject to stock) when choosing these methods. We cannot 'guarantee' a nextday delivery, though often it will arrive nextday (except during Holiday Periods). Please make your choice on the checkout page of our gifting cart. Parcels weighing over 1kg in weight will automatically be sent using Courier nextday from day of despatch unless otherwise specified. Most orders placed before 12 Noon are usually be despatched sameday but we cannot guarantee this, [email us] to find out what stage of your gift is at. Donation/Gifts placed late Friday afternoon or on a weekend, will not be sent until the following Monday or Tuesday. Should you wish to have a Saturday Delivery, there is an additional cost of £18.
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