- EUR: €7.52
- EUR: €9.83
Amla Powder – Phyllanthus emblica) rich in Ellagitannins
- EUR: €7.52
Phyllanthus emblica Linn. (syn. Emblica officinalis), commonly known as Indian gooseberry or amla, family Euphorbiaceae, is an important herbal drug used in unani (Graceo – arab) and ayurvedic systems of medicine. The plant is used both as a medicine and as a tonic to build up lost vitality and vigor. Phyllanthus emblica is highly nutritious and could be an important dietary source of vitamin C, amino acids, and minerals. The plant also contains phenolic compounds, tannins, phyllembelic acid, phyllembelin, rutin, curcum-inoids, and emblicol. All parts of the plant are used for medicinal purposes, especially the fruit, which has been used in Ayurveda as a potent rasayana and in traditional medicine for the treatment of diarrhea, jaundice, and inflammation. Various plant parts show antidiabetic, hypolipidemic, antibacterial, antioxidant, antiulcerogenic, hepatoprotective, gastroprotective, and chemopreventive properties.
Phyllanthus emblica is a tree indigenous to tropical regions of Southeast Asia. The tree produces a fruit commonly known as Indian Gooseberry or Amla. The Phyllanthus emblica fruit (also known as Emblica officinalis) or extract from these fruits has been used in traditional medicine for generations to treat symptoms ranging from constipation to the treatment of tumors .
Most commonly, the gooseberry was employed as a gentle laxative. However, the potential of Phyllanthus emblica extract to be utilized as an anticancer agent has been scrutinized using modern medical techniques over the past two decades. To date, there is substantial evidence that these extracts contain small molecules with both cancer-preventative and antitumor activity.
Traditionally, this ingredient was thought to have cooling, astringent and drying properties, and was used to stimulate hair growth by nourishing the hair and scalp and even preventing prematurely graying hair. The high tannin content of Phyllanthus Emblica was also used as a dye in inks, shampoos and hair oils.
More recent studies have found demonstrated, through in vitro tests, that Phyllanthus Emblica may have antiviral and antimicrobial properties. It is thought to contain very high amounts of Vitamin C, a powerful antioxidant known to reduce wrinkles, suppress pigmentation, and help skin retain its natural moisture. However, studies have shown that the “overall antioxidant strength of amla may derive instead from its high density of tannins and other polyphenols. The fruit also contains flavonoids, kaempferol, ellagic acid and gallic acid” (Wikipedia). An article published in the Journal of Ethnopharmacology found that Phyllanthus Emblica was an extract that ultimately did possess antioxidant and anti-inflammatory properties.
Taken prophylactically, Emblica officinalis extract reduced the genotoxic effects of heavy metals and the carcinogen benzopyrene in murine models [9, 10]. In a murine model of skin carcinogenesis, continuous administration of Emblica officinalis extract at 100 mg/kg reduced tumor incidence by ~60% . Similarly, two independent studies showed the polyphenol or aqueous fractions of Emblica officinalis administered at 60–250 mg/kg prevented N-nitrosodiethylamine induced hepatocellular carcinoma by ~80–100% [12, 13]. However, such dramatic results were not reported when Emblica officinalis extract was examined for chemoprevention of liver tumors induced by initiation with diethylnitrosamine followed by promotion with 2-acetylaminofluorene . This difference indicates Emblica officinalis has the capacity to prevent the onset of some, but not all cancers, depending on the initiator. This becomes fairly obvious when one considers carcinogenic compounds have differing modes of action; thus a single extract could not be expected to be universally chemopreventive. Hopefully, future studies will expand on these studies to examine the ability of Emblica officinalis to prevent tumors initiated by a wider variety of carcinogens at diverse tissue sites.
How are these extracts chemopreventive? There are four possibilities. First, Phyllanthus emblica has potent free radical scavenging activities that might prevent reactive oxygen species induced DNA damage and oncogenesis [15, 16]. However, in the animal models described above, it is unclear to what extent reactive oxygen species contribute to the underlying pathology, implying that there may be alternative mechanisms of action. Second, the extract has properties allowing it to reduce the levels of cytochrome enzymes in liver cells . Cytochromes, such as Cyp 450, convert xenobiotics to potentially carcinogenic substances in an effort to clear them from the body.
However, this concept is controversial as Amla extract was not found to decrease Cyp 450 levels in at least two other studies [18, 19]. Third, Phyllanthus emblica extracts have anti-inflammatory activities that might prevent inflammation related cancers . Finally, as we will describe below, Phyllanthus emblica harbors potent antitumor activity [21, 22]. Even exposure to low levels of extract from these berries may be enough to impair tumor progression at early stages. It should be noted that there is concern regarding potential hepatotoxicity after long term Amla ingestion . This matter may need to be resolved in the future by clinical and epidemiological studies before Phyllanthus emblica extract can be safely recommended for long term consumption for the prevention of cancer.
Phyllanthus emblica extract that have reproducibly been shown to have anticancer properties. Primarily, we will focus on the hydrolyzable tannin content of these extracts because of their high content within the Amla fruit  and importantly due to their known antioxidant, cancer-preventative, and cytotoxic activity in vivo [34, 35]. However, the flavonoid quercetin perhaps serves as the best paradigm for the future drug development from molecules within Amla extract having anticancer properties (described below), as this molecule has gone to clinical trial and novel analogues are being pursued. While there are other constituents of Amla extract such as vitamin C that have antioxidant activity, the only molecules having bona fide anticancer activity to date fall within the tannin or flavonoid categories.
The major constituents of Phyllanthus emblica that have been identified by HPLC and formally characterized as having anticancer activity are described below (and in Table 1). Overall, it seems reasonable that many of the anticancer properties of this fruit are derived from the tannin content. However, a notable exception to this concept is the flavonoid quercetin, which harbors potent antioxidant and anticancer properties as demonstrated utilizing multiple in vivo models of cancer including breast and leukemia [36–38].
|Table 1: Molecules from Phyllanthus emblica fruit extract having proven anticancer properties. |
Phenolic compounds from Phyllanthus emblica extract identified by HPLC having anticancer properties Cancer model utilized to identify antiproliferative and antitumor properties
Ellagic acid (tannin) Colon, prostate cell lines, and breast and prostate xenografts
Corilagin (tannin) Ovarian cancer cells, liver cancer cells, and hepatocarcinoma xenografts
Pyrogallol (tannin) Lung cancer cells, gastric cancer cells, and lung adenocarcinoma xenografts
Chebulagic acid (tannin) Retinoblastoma colon cancer, breast cancer, prostate cancer, and leukemia cancer cell lines
Gallic acid (tannin) Breast and lung cancer cell lines, some activity against lung cancer xenograft
Quercetin (flavonoid) Numerous cancer cell lines from multiple tissue types, transgenic murine model of breast cancer, leukemia xenograft, and phase I clinical trial
For References see the References Tab above.
Anticancer Properties of Phyllanthus emblica (Indian Gooseberry) from Oxidative Medicine and Cellular Longevity
Volume 2015 (2015), Article ID 950890, 7 pages.
Therapeutic potential of Phyllanthus emblica (amla): the ayurvedic wonder.
Anticancer Properties of Phyllanthus emblica (Indian Gooseberry).
Amla powder can be added to daily smoothies and with Golden Milk (Turmeric, black pepper, coconut milk, honey, ginger, cinnamon) after the heated milk has been cooled down with some filtered water.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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References from 'Anticancer Properties of Phyllanthus emblica (Indian Gooseberry)'; http://www.hindawi.com/journals/omcl/2015/950890/
1. J. Ferlay, I. Soerjomataram, R. Dikshit et al., “Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012,” International Journal of Cancer, vol. 136, no. 5, pp. E359–E386, 2015.
2. P. Hanly, I. Soerjomataram, and L. Sharp, “Measuring the societal burden of cancer: the cost of lost productivity due to premature cancer-related mortality in Europe,” International Journal of Cancer, vol. 136, no. 4, pp. E136–E45, 2015.
3. G. A. Colditz and K. Bohlke, “Priorities for the primary prevention of breast cancer,” CA Cancer Journal for Clinicians, vol. 64, no. 3, pp. 186–194, 2014.
4. C. C. Huang, W. T. Lee, S. T. Tsai, et al., “Tea consumption and risk of head and neck cancer,” PLoS ONE, vol. 9, no. 5, Article ID e96507, 2014.
5. L. Wang, X. Zhang, J. Liu, L. Shen, and Z. Li, “Tea consumption and lung cancer risk: a meta-analysis of case-control and cohort studies,” Nutrition, vol. 30, no. 10, pp. 1122–1127, 2014.
6. A. H. Eliassen, S. J. Hendrickson, L. A. Brinton et al., “Circulating carotenoids and risk of breast cancer: pooled analysis of eight prospective studies,” Journal of the National Cancer Institute, vol. 104, no. 24, pp. 1905–1916, 2012.
7. D. W. Unander, G. L. Webster, and B. S. Blumberg, “Records of usage or assays in Phyllanthus (Euphorbiaceae) I. Subgenera Isocladus, Kirganelia, Cicca and Emblica,” Journal of Ethnopharmacology, vol. 30, no. 3, pp. 233–264, 1990.
8. N. Sharma, P. Trikha, M. Athar, and S. Raisuddin, “In vitro inhibition of carcinogen-induced mutagenicity by Cassia occidentalis and Emblica officinalis,” Drug and Chemical Toxicology, vol. 23, no. 3, pp. 477–484, 2000.
9. P. Nandi, G. Talukder, and A. Sharma, “Dietary chemoprevention of clastogenic effects of 3,4-benzo(a)pyrene by Emblica officinalis Gaertn. fruit extract,” British Journal of Cancer, vol. 76, no. 10, pp. 1279–1283, 1997.
10. H. Dhir, A. K. Roy, A. Sharma, and G. Talukder, “Modification of clastogenicity of lead and aluminium in mouse bone marrow cells by dietary ingestion of Phyllanthus emblica fruit extract,” Mutation Research, vol. 241, no. 3, pp. 305–312, 1990.
11. G. Sancheti, A. Jindal, R. Kumari, and P. K. Goyal, “Chemopreventive action of Emblica officinalis on skin carcinogenesis in mice,” Asian Pacific Journal of Cancer Prevention, vol. 6, no. 2, pp. 197–201, 2005.
12. N. V. Rajeshkumar, M. R. Pillai, and R. Kuttan, “Induction of apoptosis in mouse and human carcinoma cell lines by Emblica officinalis polyphenols and its effect on chemical carcinogenesis,” Journal of Experimental and Clinical Cancer Research, vol. 22, no. 2, pp. 201–212, 2003.
13. K. J. Jeena, K. L. Joy, and R. Kuttan, “Effect of Emblica officinalis, Phyllanthus amarus and Picrorrhiza kurroa on N-nitrosodiethylamine induced hepatocarcinogenesis,” Cancer Letters, vol. 136, no. 1, pp. 11–16, 1999.
14. S. Sultana, S. Ahmed, and T. Jahangir, “Emblica officinalis and hepatocarcinogenesis: a chemopreventive study in Wistar rats,” Journal of Ethnopharmacology, vol. 118, no. 1, pp. 1–6, 2008. View at Publisher ·
15. B. Hazra, R. Sarkar, S. Biswas, and N. Mandal, “Comparative study of the antioxidant and reactive oxygen species scavenging properties in the extracts of the fruits of Terminalia chebula, Terminalia belerica and Emblica officinalis,” BMC Complementary and Alternative Medicine, vol. 10, article 20, 2010.
16. M. Majeed, B. Bhat, A. N. Jadhav, J. S. Srivastava, and K. Nagabhushanam, “Ascorbic acid and tannins from Emblica officinalis Gaertn. Fruits—a revisit,” Journal of Agricultural and Food Chemistry, vol. 57, no. 1, pp. 220–225, 2009.
17. S. M. Banu, K. Selvendiran, J. P. V. Singh, and D. Sakthisekaran, “Protective effect of Emblica officinalis ethanolic extract against 7,12-dimethylbenz(a)anthracene (DMBA) induced genotoxicity in Swiss albino mice,” Human and Experimental Toxicology, vol. 23, no. 11, pp. 527–531, 2004.
18. K.-H. Chen, B.-R. Lin, C.-T. Chien, and C.-H. Ho, “Emblica officinalis gaertn. attentuates N-nitrosodiethylamine-induced apoptosis, autophagy, and inflammation in rat livers,” Journal of Medicinal Food, vol. 14, no. 7-8, pp. 746–755, 2011.
19. S. A. Tasduq, D. M. Mondhe, D. K. Gupta, M. Baleshwar, and R. K. Johri, “Reversal of fibrogenic events in liver by Emblica officinalis (fruit), an Indian natural drug,” Biological and Pharmaceutical Bulletin, vol. 28, no. 7, pp. 1304–1306, 2005.
20. M. Golechha, V. Sarangal, S. Ojha, J. Bhatia, and D. S. Arya, “Anti-inflammatory effect of Emblica officinalis in rodent models of acute and chronic inflammation: involvement of possible mechanisms,” International Journal of Inflammation, vol. 2014, Article ID 178408, 6 pages, 2014.
21. M. S. Baliga and J. J. Dsouza, “Amla (Emblica officinalis Gaertn), a wonder berry in the treatment and prevention of cancer,” European Journal of Cancer Prevention, vol. 20, no. 3, pp. 225–239, 2011.
22. B. Yang and P. Liu, “Composition and biological activities of hydrolyzable tannins of fruits of phyllanthus emblica,” Journal of Agricultural and Food Chemistry, vol. 62, no. 3, pp. 529–541, 2014.
23. C. Wiart, “Note on the relevance of Emblica officinalis Gaertn. for the treatment and prevention of cancer,” European Journal of Cancer Prevention, vol. 22, no. 2, article 198, 2013.
24. C. Ngamkitidechakul, K. Jaijoy, P. Hansakul, N. Soonthornchareonnon, and S. Sireeratawong, “Antitumour effects of Phyllanthus emblica L.: induction of cancer cell apoptosis and inhibition of in vivo tumour promotion and in vitro invasion of human cancer cells,” Phytotherapy Research, vol. 24, no. 9, pp. 1405–1413, 2010.
25. L. S. Adams, S. Phung, N. Yee, N. P. Seeram, L. Li, and S. Chen, “Blueberry phytochemicals inhibit growth and metastatic potential of MDA-MB-231 breast cancer cells through modulation of the phosphatidylinositol 3-kinase pathway,” Cancer Research, vol. 70, no. 9, pp. 3594–3605, 2010.
26. R. R. Somasagara, M. Hegde, K. K. Chiruvella, A. Musini, B. Choudhary, and S. C. Raghavan, “Extracts of strawberry fruits induce intrinsic pathway of apoptosis in breast cancer cells and inhibits tumor progression in mice,” PLoS ONE, vol. 7, no. 10, Article ID e47021, 2012.
27. A. De, C. Papasian, S. Hentges, S. Banerjee, I. Haque, and S. K. Banerjee, “Emblica officinalis extract induces autophagy and inhibits human ovarian cancer cell proliferation, angiogenesis, growth of mouse xenograft tumors,” PLoS ONE, vol. 8, no. 8, Article ID e72748, 2013.
28. X. Zhu, J. Wang, Y. Ou, W. Han, and H. Li, “Polyphenol extract of Phyllanthus emblica (PEEP) induces inhibition of cell proliferation and triggers apoptosis in cervical cancer cells,” European Journal of Medical Research, vol. 18, no. 1, article 46, 2013.
29. M. M. Shivananjappa and M. K. Joshi, “Influence of Emblica officinalis aqueous extract on growth and antioxidant defense system of human hepatoma cell line (HepG2),” Pharmaceutical Biology, vol. 50, no. 4, pp. 497–505, 2012.
30. S. Rawal, P. Singh, A. Gupta, and S. Mohanty, “Dietary intake of Curcuma longa and Emblica officinalis increases life span in Drosophila melanogaster,” BioMed Research International, vol. 2014, Article ID 910290, 7 pages, 2014.
31. S. Mahata, A. Pandey, S. Shukla et al., “Anticancer activity of Phyllanthus emblica Linn. (Indian Gooseberry): inhibition of transcription factor ap-1 and HPV gene expression in cervical cancer cells,” Nutrition and Cancer, vol. 65, supplement 1, pp. 88–97, 2013. V
32. E. A. Poltanov, A. N. Shikov, H. J. D. Dorman et al., “Chemical and antioxidant evaluation of Indian gooseberry (Emblica officinalis Gaertn., syn. Phyllanthus emblica L.) supplements,” Phytotherapy Research, vol. 23, no. 9, pp. 1309–1315, 2009.
33. B. Yang, M. Kortesniemi, P. Liu, M. Karonen, and J.-P. Salminen, “Analysis of hydrolyzable tannins and other phenolic compounds in emblic leafflower (Phyllanthus emblica L.) fruits by high performance liquid chromatography-electrospray ionization mass spectrometry,” Journal of Agricultural and Food Chemistry, vol. 60, no. 35, pp. 8672–8683, 2012.
34. T. Zhao, Q. Sun, S. V. Del Rincon, A. Lovato, M. Marques, and M. Witcher, “Gallotannin imposes S phase arrest in breast cancer cells and suppresses the growth of triple-negative tumors in vivo,” PLoS ONE, vol. 9, no. 3, Article ID e92853, 2014.
35. Y. Chai, H.-J. Lee, A. A. Shaik et al., “Penta-O-galloyl-β-D-glucose induces G1 arrest and DNA replicative S-phase arrest independently of P21 cyclin-dependent kinase inhibitor 1A, P27 cyclin-dependent kinase inhibitor 1B and P53 in human breast cancer cells and is orally active against triple-negative xenograft growth,” Breast Cancer Research, vol. 12, no. 5, article R67, 2010.
36. C. Spagnuolo, M. Russo, S. Bilotto, I. Tedesco, B. Laratta, and G. L. Russo, “Dietary polyphenols in cancer prevention: the example of the flavonoid quercetin in leukemia,” Annals of the New York Academy of Sciences, vol. 1259, no. 1, pp. 95–103, 2012.
37. J. L. Steiner, J. M. Davis, J. L. McClellan et al., “Dose-dependent benefits of quercetin on tumorigenesis in the C3(1)/SV40Tag transgenic mouse model of breast cancer,” Cancer Biology & Therapy, vol. 15, no. 11, pp. 1456–1467, 2014.
38. S. Cheng, N. Gao, Z. Zhang et al., “Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax,” Clinical Cancer Research, vol. 16, no. 23, pp. 5679–5691, 2010.
39. A. Galano, M. Francisco Marquez, and A. Pérez-González, “Ellagic acid: an unusually versatile protector against oxidative stress,” Chemical Research in Toxicology, vol. 27, no. 5, pp. 904–918, 2014.
40. M. Singh, A. Jha, A. Kumar, N. Hettiarachchy, A. K. Rai, and D. Sharma, “Influence of the solvents on the extraction of major phenolic compounds (punicalagin, ellagic acid and gallic acid) and their antioxidant activities in pomegranate aril,” Journal of Food Science and Technology, vol. 51, no. 9, pp. 2070–2077, 2014.
41. A. Manosroi, P. Jantrawut, H. Akazawa, T. Akihisa, and J. Manosroi, “Biological activities of phenolic compounds isolated from galls of Terminalia chebula Retz. (Combretaceae),” Natural Product Research, vol. 24, no. 20, pp. 1915–1926, 2010.
42. P. S. Makena and K.-T. Chung, “Effects of various plant polyphenols on bladder carcinogen benzidine-induced mutagenicity,” Food and Chemical Toxicology, vol. 45, no. 10, pp. 1899–1909, 2007.
43. A. Dipple, “DNA adducts of chemical carcinogens,” Carcinogenesis, vol. 16, no. 3, pp. 437–441, 1995.
44. R. Piva, L. Penolazzi, M. Borgatti et al., “Apoptosis of human primary osteoclasts treated with molecules targeting nuclear factor-kappaB,” Annals of the New York Academy of Sciences, vol. 1171, pp. 448–456, 2009.
45. H.-H. Ho, C.-S. Chang, W.-C. Ho, S.-Y. Liao, C.-H. Wu, and C.-J. Wang, “Anti-metastasis effects of gallic acid on gastric cancer cells involves inhibition of NF-κB activity and downregulation of PI3K/AKT/small GTPase signals,” Food and Chemical Toxicology, vol. 48, no. 8-9, pp. 2508–2516, 2010.
46. H. H. Ho, C.-S. Chang, W.-C. Ho, S.-Y. Liao, W.-L. Lin, and C.-J. Wang, “Gallic acid inhibits gastric cancer cells metastasis and invasive growth via increased expression of RhoB, downregulation of AKT/small GTPase signals and inhibition oView at Publisher · View at Google Scholar · View at Scopus
47. L. Penolazzi, I. Lampronti, M. Borgatti et al., “Induction of apoptosis of human primary osteoclasts treated with extracts from the medicinal plant Emblica officinalis,” BMC Complementary and Alternative Medicine, vol. 8, article 59, 2008. View at Publisher · View at Google Scholar · View at Scopus
48. M. Edderkaoui, I. Odinokova, I. Ohno et al., “Ellagic acid induces apoptosis through inhibition of nuclear factor κB in pancreatic cancer cells,” World Journal of Gastroenterology, vol. 14, no. 23, pp. 3672–3680, 2008. View at Publisher · View at Google Scholar · View at Scopus
49. P. Anitha, R. V. Priyadarsini, K. Kavitha, P. Thiyagarajan, and S. Nagini, “Ellagic acid coordinately attenuates Wnt/beta-catenin and NF-kappaB signaling pathways to induce intrinsic apoptosis in an animal model of oral oncogenesis,” European Journal of Nutrition, vol. 52, no. 1, pp. 75–84, 2013.
50. L. Jia, H. Jin, J. Zhou et al., “A potential anti-tumor herbal medicine, Corilagin, inhibits ovarian cancer cell growth through blocking the TGF-β signaling pathways,” BMC Complementary and Alternative Medicine, vol. 13, article 33, 2013.
51. C. Gasparini, C. Celeghini, L. Monasta, and G. Zauli, “NF-kappaB pathways in hematological malignancies,” Cellular and Molecular Life Sciences, vol. 71, no. 11, pp. 2083–2102, 2014.
52. H.-M. Shen and V. Tergaonkar, “NFkappaB signaling in carcinogenesis and as a potential molecular target for cancer therapy,” Apoptosis, vol. 14, no. 4, pp. 348–363, 2009.
53. B. Hoesel and J. A. Schmid, “The complexity of NF-κB signaling in inflammation and cancer,” Molecular Cancer, vol. 12, no. 1, article 86, 2013. View at Publisher · View at Google Scholar · View at Scopus
C.-J. Yang, C.-S. Wang, J.-Y. Hung et al., “Pyrogallol induces G2-M arrest in human lung cancer cells and inhibits tumor growth in an animal model,” Lung Cancer, vol. 66, no. 2, pp. 162–168, 2009. View at Publisher · View at Google Scholar · View at Scopus
I. M. Adcock, C. R. Brown, O. Kwon, and P. J. Barnes, “Oxidative stress induces NFκB DNA binding and inducible NOS mRNA in human epithelial cells,” Biochemical and Biophysical Research Communications, vol. 199, no. 3, pp. 1518–1524, 1994. View at Publisher · View at Google Scholar · View at Scopus
H. J. Kim, J. Kim, K. S. Kang, K. T. Lee, and H. O. Yang, “Neuroprotective effect of chebulagic acid via autophagy induction in SH-SY5Y cells,” Biomolecules & Therapeutics, vol. 22, no. 4, pp. 275–281, 2014. View at Publisher · View at Google Scholar
D. M. Benbrook and A. Long, “Integration of autophagy, proteasomal degradation, unfolded protein response and apoptosis,” Experimental Oncology, vol. 34, no. 3, pp. 286–297, 2012. View at Google Scholar · View at Scopus
L. T. Lee, Y. T. Huang, J. J. Hwang et al., “Blockade of the epidermal growth factor receptor tyrosine kinase activity by quercetin and luteolin leads to growth inhibition and apoptosis of pancreatic tumor cells,” Anticancer Research, vol. 22, no. 3, pp. 1615–1627, 2002. View at Google Scholar · View at Scopus
F. A. Bhat, G. Sharmila, S. Balakrishnan et al., “Quercetin reverses EGF-induced epithelial to mesenchymal transition and invasiveness in prostate cancer (PC-3) cell line via EGFR/PI3K/Akt pathway,” The Journal of Nutritional Biochemistry, vol. 25, no. 11, pp. 1132–1139, 2014. View at Publisher · View at Google Scholar
E. H. Walker, M. E. Pacold, O. Perisic et al., “Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine,” Molecular Cell, vol. 6, no. 4, pp. 909–919, 2000. View at Publisher · View at Google Scholar · View at Scopus
S. P. Davies, H. Reddy, M. Caivano, and P. Cohen, “Specificity and mechanism of action of some commonly used protein kinase inhibitors,” Biochemical Journal, vol. 351, no. 1, pp. 95–105, 2000. View at Publisher · View at Google Scholar · View at Scopus
C. Marienfeld, L. Tadlock, Y. Yamagiwa, and T. Patel, “Inhibition of cholangiocarcinoma growth by tannic acid,” Hepatology, vol. 37, no. 5, pp. 1097–1104, 2003. View at Publisher · View at Google Scholar · View at Scopus
N. Wang, Z.-Y. Wang, S.-L. Mo et al., “Ellagic acid, a phenolic compound, exerts anti-angiogenesis effects via VEGFR-2 signaling pathway in breast cancer,” Breast Cancer Research and Treatment, vol. 134, no. 3, pp. 943–955, 2012. View at Publisher · View at Google Scholar · View at Scopus
M. V. Vadhanam, S. Ravoori, F. Aqil, and R. C. Gupta, “Chemoprevention of mammary carcinogenesis by sustained systemic delivery of ellagic acid,” European Journal of Cancer Prevention, vol. 20, no. 6, pp. 484–491, 2011. View at Publisher · View at Google Scholar · View at Scopus
A. Naiki-Ito, T. Chewonarin, M. Tang et al., “Ellagic acid, a component of pomegranate fruit juice, suppresses androgen-dependent prostate carcinogenesis via induction of apoptosis,” The Prostate, vol. 75, no. 2, pp. 151–160, 2015. View at Publisher · View at Google Scholar
D. K.-P. Hau, G.-Y. Zhu, A. K.-M. Leung et al., “In vivo anti-tumour activity of corilagin on Hep3B hepatocellular carcinoma,” Phytomedicine, vol. 18, no. 1, pp. 11–15, 2010. View at Publisher · View at Google Scholar · View at Scopus
B. C. Ji, W. H. Hsu, J. S. Yang, and et al, “Gallic acid induces apoptosis via caspase-3 and mitochondrion-dependent pathways in vitro and suppresses lung xenograft tumor growth in vivo,” Journal of Agricultural and Food Chemistry, vol. 57, no. 16, pp. 7596–7604, 2009. View at Publisher · View at Google Scholar · View at Scopus
C.-Z. Liang, X. Zhang, H. Li et al., “Gallic acid induces the apoptosis of human osteosarcoma cells in vitro and in vivo via the regulation of mitogen-activated protein kinase pathways,” Cancer Biotherapy and Radiopharmaceuticals, vol. 27, no. 10, pp. 701–710, 2012. View at Publisher · View at Google Scholar · View at Scopus
E. Angst, J. L. Park, A. Moro et al., “The flavonoid quercetin inhibits pancreatic cancer growth in vitro and in vivo,” Pancreas, vol. 42, no. 2, pp. 223–229, 2013. View at Publisher · View at Google Scholar · View at Scopus
D. R. Ferry, A. Smith, J. Malkhandi et al., “Phase I clinical trial of the flavonoid quercetin: pharmacokinetics and evidence for in vivo tyrosine kinase inhibition,” Clinical Cancer Research, vol. 2, no. 4, pp. 659–668, 1996. View at Google Scholar · View at Scopus
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from £9.00 or 3 day courier service from £21]
* Please ensure that someone is available to sign for the parcel at the delivery address. You may provide a work address if you wish during the checkout process. Royal Mail will only make ONE delivery attempt, if nobody is available at the address, they will leave a card and expect you to contact them, they cannot leave with a neighbour unless you pre-arrange this with us. A re-delivery will cost £3.00 and a change of address will be £6.50, you may also collect from their collection office. If the shipment is not collected after 4 days they will return it back to us, re-deliveries will be chargeable.
Please Note: These costs are for most items. We reserve the right to adjust costs to reflect the additional cost of shipping items of greater than average weight . Shipping & Handling is based on weight of the Order using the following schedule (all donations are in GBP and not subject to VAT)
Delivery Zones Worldwide
Note, if you choose the wrong delivery zone, we will re-calculate the delivery charge and advise you by email if there is any donation shortfall to ask you to pay the balance on paypal..
British Isles / Free if not urgent! Surface Mail / Courier from £10England, Scotland, Norther Ireland, Wales, Channel Islands, I.O.M
Europe / Baltics / Russia - Surface MailIrish Republic, Belgium, France, Germany, Greece, Hungary, Italy, Netherlands, Portugal, Romania, Spain , Med. Islands , Austria, Bulgaria, Cyprus, Czech Republic, Denmark, Estonia, Finland, Hungary, Israel, Luxembourg, Lithuania, Latvia, Malta, Norway, Poland, Russia, Romania, Slovakia, Slovenia, Serbia, Sweden,
Outside Europe / Asia / USA / Southern Hemisphere - Surface Mail or CourierAfrica , Albania, Algeria, Australia, Botswana, Bahamas, Canada, Canary Islands, Croatia, Egypt, Jamaica, Jordan, Kenya, Malaysia, Mauritius, Monaco, Moldova, Morocco, South Africa, Sudan, Switzerland, Syria, Turkey, Ukraine, Zambia, Argentina, Barbados, Brazil, Chile, Colombia, Costa Rica, Equador, Israel, Jamaica, Kuwait, Libya, Lebanon, Mexico, Oman, Peru, Puerta Rica, Saudi Arabia, Singapore, Taiwan, Thailand, UAE, Uraguay, Yemen, Australia, Bali, China, Hong Kong, Indonesia, Japan, South Korea, Malaysia, New Zealand.
|Delivery Region (Regular Mail and Couriers)||Delivery Costs (Approx.)|
|British Isles - FREE if over £35 order value |
(5 to 7 days)
|>5kg FREE but Not Insured!|
British Isles / Royal Mail
British Isles / Hermes Courier (2 - 3 days)
|Europe + Baltics + Russia Surface Mail (approx 1 week) || |
|Europe / Ireland Courier ( 3 days)|| |
|Outside EU (approx 7 - 10 days) |
(7-10 days mail
1kg £21.00 Use Cour.
|Outside EU Courier |
(3 days UPS, option is insured)
Warranty and Returns PolicyWe can provide a refund if you are unhappy with your gift but you will need to pay the return costs and the individual items must not have been opened and must be returned in original condition and with all packaging intact. Any refunds which are authorised should be returned to the address on the paperwork with a copy of it along with your reason for return. Items MUST be returned in the condition they were sold in.
USA and International Gifts:Must be received before 11.00am to be despatched on the same day (note: £1 is approx $1.30 USD & €1.14 EUR, use this Currency Convertor to find the latest exchange rates)
Special Delivery are a fast and reliable service. The delivery to the British Isles is a 1-2 day service (subject to stock) when choosing these methods. We cannot 'guarantee' a nextday delivery, though often it will arrive nextday (except during Holiday Periods). Please make your choice on the checkout page of our gifting cart. Parcels weighing over 1kg in weight will automatically be sent using Courier nextday from day of despatch unless otherwise specified. Most orders placed before 12 Noon are usually be despatched sameday but we cannot guarantee this, [email us] to find out what stage of your gift is at. Donation/Gifts placed late Friday afternoon or on a weekend, will not be sent until the following Monday or Tuesday. Should you wish to have a Saturday Delivery, there is an additional cost of £18.
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Complete plant protein from hemp, blended with 15 other beneficial herbs and superfoods for use in shakes, smoothies or with yogurts. Hempamine consists of 90% Hemp Plant Protein & Fibre and includes 10% Beneficial Herbs & Superfoods is highly bioavailable. It is a rich source of BCAA, Omega 3 (EFA) and fibre for Gut Health an may reduce bloating.
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