Reversing the Bone Damage caused by Anti-Cancer Drugs
|Key Bone ‘Rescue’ Protocol Ingredients
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According to Cancer Research UK… “Any cancer treatment in women that lowers oestrogen levels can increase the risk of osteoporosis.
Treatments that lower oestrogen levels and may increase the risk of osteoporosis include
- Chemotherapy that caused an early menopause
- Hormone therapy with a drug called an LHRH analogue (eg Zoladex)
- Hormone therapy with a drug called an aromatase inhibitor (such as anastrozole, exemestane or letrozole)
- Radiotherapy to your ovaries to stop them working
- Surgery to remove your ovaries when you were premenopausal
Tamoxifen for breast cancer usually only reduces bone density by a small amount. In postmenopausal women, aromatase inhibitors increase bone loss at an average rate of 1 to 3% per year. In young women who have had ovarian suppression followed by aromatase inhibitor therapy, bone density is lost at an average of 7 to 8% per year. Treatment with tamoxifen for 2 to 5 years before having aromatase inhibitors may slow down the rate of bone loss.
Women who have had an early menopause (before the age of 45) due to cancer treatment or who have ovarian suppression therapy and aromatase inhibitors are at higher risk of bone loss.” source
The best that CRUK can offer in terms of advice is to take Calcium and don’t drink coffee, alcohol or smoke, all good advice but it’s not going to restore the bone mineral density you’ve lost, and just when you think it can’t get any worse CRUK suggest Biphosphanates to reduce bone loss, which have an horrendous list of side effects which include bone pain, shaking and loose teeth . Fortunately there’s so much more you can do to reverse the condition of losing bone mineral density after cancer treatment.
So.. synthetic AIs; that is, anastrozole, letrozole and exemestane have become the standard of care for the adjuvant treatment of hormone-responsive breast cancer in postmenopausal women. For many years, tamoxifen was the cornerstone of endocrinetherapy .
However, recent clinical trials of synthetic AIs have shown benefits over tamoxifen. The main advantages are improvement of disease-free survival, decreased rates of contralateral breast cancer and a more favorable toxicity profile, with lower rates of thrombo embolic phenomena and endometrial malignancy [2-8].
These trials reported incidences of musculoskeletal symptoms ranging from 5% to 35%. Observational studies, have shown that synthetic aromatase inhibitor-associated musculoskeletal symptoms (AIMSS) are more prevalent than originally reported [9,10]. In a cross-sectional survey of 200 women receiving adjuvant synthetic AI therapy for breast cancer, 94 (47%) reported AI-associated joint pain, and 88 (44%) reported joint stiffness; nearly 13% of patients discontinued therapy because of intolerable musculoskeletal symptoms . Because the mechanisms mediating AIMSS are not clearly understood, effective management of AIMSS has not yet been developed.
Potential interventions for AIMSS usually include non-steroidal anti- inflammatory drugs, analgesics , calcitriolagents, vitamin D, and exercise. Some patients even have to switch synthetic AIs or switch to tamoxifen because of severe musculoskeletal symptoms [11,12]. However, it is not clear whether any of these interventions have had a dramatic effect on musculoskeletal symptoms.
Therefore, due to the unsatisfactory response to current symptomatic treatments, many patients seek help from traditional Chinese medicine (TCM). TCM, which has a unique advantage in alleviating symptoms and improving quality of life, and has been widely applied in China for the treatment of cancer-related side effects, such as nausea, vomiting, fatigue, tidal fever, and pain [13,14]. Postmenopausal women with AIMSS exhibit a specific pathological change associated with deficiency of kidney essence and depression of liver qi, according to TCM theory .
Insufficient kidney essence results in failure to nourish the related body constituents and organs, including bone and joints.
Liver qi depression leads to stagnation of qi movement, manifested as pain .
Through the use of the BoneMaker protocol,which, according to therapeutic principle of TCM, would tonify the kidney, fortify the bone, soothe and raise the liver qi, relieve some of the pain and supply nutrients required to build the bones.
Nutraceutical DisclaimerThese statements have not been evaluated by the Food and Drug Administration or MHRA and the items are not intended to diagnose, treat, cure, or prevent any disease nor are they associated, endorsed, affiliated or sponsored by Anthony William or Medical Medium®.
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